anti-Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) Antibodies

HNRNPU belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Additionally we are shipping Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Kits (35) and Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HNRNPU 51810 Q8VEK3
HNRNPU 117280  
HNRNPU 3192 Q00839
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Top anti-Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-HNRNPU Antibody Titration:  0.2-1 ug/ml  Positive Control:  MCF7 cell lysate HNRNPU is supported by BioGPS gene expression data to be expressed in MCF7 Host:  Mouse  Target Name:  HNRNPU  Sample Tissue:  Mouse Liver  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HNRNPU Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  ACHN cell lysate HNRNPU is strongly supported by BioGPS gene expression data to be expressed in Human ACHN cells WB Suggested Anti-HNRNPU  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: ACHN cell lysate  HNRNPU is strongly supported by BioGPS gene expression data to be expressed in Human ACHN cells 100 μL Log in to see 2 to 3 Days
$319.00
Details
Mouse Mouse Un-conjugated ChIP, ELISA, FACS, ICC, IF, IHC (p), IP, WB Western blot showing Anti-hnRNP-U on HeLa cell extracts 50 μL Log in to see 7 to 8 Days
$447.65
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: hnRNP U Antibody [NBP2-49290] - Analysis of human cell line Hep G2 shows positivity in nucleus but excluded from the nucleoli. Immunohistochemistry-Paraffin: hnRNP U Antibody [NBP2-49290] - Staining of human cerebral cortex shows strong nuclear positivity in neuronal cells, glial cells and endothelial cells, neuropil is negative. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Western Blot: hnRNP U Antibody [ABIN151573] - Detection of Human and Mouse hnRNP-U on HeLa whole cell lysate using ABIN151573. 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), IP, WB Anti-HnRNP U / p120 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1102132 dilution 10 ug/ml. Anti-HnRNP U / p120 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. 50 μL Log in to see 11 to 14 Days
$639.83
Details
Human Rabbit Un-conjugated IHC, IP, WB 100 μL Log in to see 16 Days
$366.77
Details
Cow Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details

Top referenced anti-Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Antibodies

  1. Mouse (Murine) Monoclonal HNRNPU Primary Antibody for ChIP, ELISA - ABIN108577 : Dreyfuss, Choi, Adam: Characterization of heterogeneous nuclear RNA-protein complexes in vivo with monoclonal antibodies. in Molecular and cellular biology 1984 (PubMed)
    Show all 8 Pubmed References

  2. Mouse (Murine) Monoclonal HNRNPU Primary Antibody for ChIP, ELISA - ABIN108578 : Ahmad, Lingrel: Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases. in Biochemistry 2005 (PubMed)
    Show all 8 Pubmed References

  3. Mouse (Murine) Polyclonal HNRNPU Primary Antibody for IC, IF - ABIN2452032 : Kiledjian, Dreyfuss: Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. in The EMBO journal 1992 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal HNRNPU Primary Antibody for IHC (p), IHC - ABIN151573 : Banerjee, Mandal, Das, Hegde, Das, Bhakat, Boldogh, Sarkar, Mitra, Hazra: Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. in The Journal of biological chemistry 2011 (PubMed)

  5. Human Polyclonal HNRNPU Primary Antibody for IP, WB - ABIN151574 : Powell, Coulson, Crary, Wong, Ach, Tsang, Alice Yamada, Yasui, Lasalle: A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. in Human molecular genetics 2013 (PubMed)

More Antibodies against Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) Interaction Partners

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) interaction partners

  1. we demonstrated that HNRNPU functions as a major factor maintaining 3D chromatin architecture, suggesting important roles of NM-associated proteins in genome organization.

  2. We found that heterogeneous nuclear ribonucleoprotein U (hnRNP U) is essential for the expression of Avp and Vip. Loss of one copy of the Hnrnpu gene resulted in fragmented locomotor activities and disrupted metabolic rhythms. Hnrnpu(+/-) mice were more active than wild-type mice in the daytime but more inactive at night.

  3. findings provide conclusive evidence for the essential role of hnRNP U in heart development and function and in the regulation of alternative splicing.

  4. SAF-A interacts with BRG1 and both components are required for RNA Polymerase II Mediated Transcription

  5. Macrophage expression of hnRNP U was induced by TLR stimulation. hnRNP U knockdown attenuated & overexpression increased TLR-induced expression of TNF-alpha, IL-6 & IL-1beta. hnRNP U bound to the mRNA of these cytokines via the RGG motif.

  6. Data report that endogenous SAF-A is involved in regulation of Oct4 expression, binds the Oct4 proximal promoter in ES cells, and dissociates from the promoter upon early differentiation induced by LIF withdrawal.

  7. hnRNP-U engages a highly neddylated active SCF beta-TrCP which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter.

  8. hnRNP U participates in nuclear regulatory events that are involved in mammalian central and peripheral circadian clocks.

  9. nuclear matrix protein SAF-A binds to the 3'-flanking region of the Bmal1 gene with circadian timing

  10. HnRNP U binding to the 5'-UTR of the Shh facilitates gene expression during limb development.

  11. SAF-A was found to be localized in three different domains: outside the chromosomes, on the surface of the chromosome arms, and in the centromere region where it apparently binds specifically to the satellite DNA.

  12. the c-Myc-Max complex exerts its transcriptional regulatory role and hnRNP U may be a coactivator of this transcriptional activator complex.

Human Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) interaction partners

  1. This series demonstrates common phenotypic features, including emerging dysmorphism, associated with heterozygous HNRNPU mutations. This allows us to define a novel neurodevelopmental syndrome, with a likely mechanism of haploinsufficiency

  2. SAF-A, in concert with Ku, temporally regulates base damage repair in irradiated cell genome.

  3. HNRPU deletion is associated with neurodevelopmental disorders.

  4. We broaden the clinical and mutational HNRNPU-associated spectrum, and demonstrate that heterozygous HNRNPU variants cause epilepsy, severe intellectual disability with striking speech impairment and variable central nervous system, cardiac, and renal anomalies.

  5. Results show that SAF-A and caRNAs form a dynamic, transcriptionally responsive chromatin mesh that organizes large-scale chromosome structures and protects the genome from instability.

  6. results confirm and refine the complex genotype-phenotype correlations existing in the 1qter microdeletion syndrome and define more precisely the neurodevelopmental phenotypes associated with genetic alterations of AKT3, ZBTB18 and HNRNPU in humans

  7. mutual regulatory mechanisms exist between PP4 and SAF-A. Interactions between PP4 and SAF-A played a role in prometaphase/metaphase transition.

  8. CENP-W interacts with hnRNPU and may contribute to kinetochore-microtubule attachment in mitotic cells.

  9. Nuclear TDP-43 becomes neurotoxic by escaping from the inhibitory regulation by hnRNP-U or hnRNP-A2. hnRNP-U inhibits TDP-43-mediated alterations in splicing of POLDIP3 mRNA.

  10. These results suggest that HNRNPU, FAM36A, and NCRNA00201 are not major genes for microcephaly and corpus callosum abnormalities but are good candidates for intellectual disability (ID) and seizures.

  11. both phosphorylation and dephosphorylation of SAF-A serine 59 by PLK1 and PP2A, respectively, are required for accurate and timely exit from mitosis.

  12. demonstrate that H19 inhibits RNA Pol II-mediated transcription by disrupting the hnRNP U-actin complex

  13. Induction of caspase-9b expression is due to activation of hnRNP L via phosphorylation to compete/inhibit hnRNP U association with exon 3 of Casp9 mRNA.

  14. the hnRNP-U protection of cells after oxidative stress is largely due to enhancement of NEIL1-mediated repair.

  15. experimentally verified the targets heterogeneous nuclear ribonucleoprotein U, phosphatidylinositol-3-OH kinase, the WNK (with-no-lysine) kinase family and USP19 (ubiquitin-specific peptidase 19) as vulnerable nodes in the host cellular defence system against viruses

  16. SAF-A interacts with BRG1 and both components are required for RNA Polymerase II Mediated Transcription

  17. hnRNP U is a regulator of SMN2 splicing.

  18. The nuclear scaffold protein (SAF-A) is a novel spindle regulator that plays an essential role in kinetochore-microtubules (MT)attachment and mitotic spindle organization.

  19. Single nucleotide polymorphism in HNRPU gene is associated with speech delay, seizures and variable corpus callosum thickness.

Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) Antigen Profile

Protein Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with HNRNPU

  • heterogeneous nuclear ribonucleoprotein U (Hnrnpu) antibody
  • heterogeneous nuclear ribonucleoprotein U (HNRNPU) antibody
  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) S homeolog (hnrnpu.S) antibody
  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (HNRNPU) antibody
  • AA408410 antibody
  • AI256620 antibody
  • AL024194 antibody
  • AL024437 antibody
  • AW557595 antibody
  • C86794 antibody
  • hnRNP U antibody
  • HNRPU antibody
  • saf-a antibody
  • SAFA antibody
  • SN1 antibody
  • Sp120 antibody
  • U21.1 antibody

Protein level used designations for HNRNPU

SAF-A , heterogenous nuclear ribonucleoprotein U , nuclear matrix protein sp120 , scaffold attachment factor A , system N1 Na+ and H+-coupled glutamine transporter , transporter protein , transporter protein; system N1 Na+ and H+-coupled glutamine transporter , heterogeneous nuclear ribonucleoprotein U , p120 nuclear protein , pp120

GENE ID SPECIES
51810 Mus musculus
117280 Rattus norvegicus
100348766 Oryctolagus cuniculus
3192 Homo sapiens
399374 Xenopus laevis
539950 Bos taurus
100515571 Sus scrofa
421492 Gallus gallus
100725944 Cavia porcellus
101107118 Ovis aries
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