HNRNPU antibody (C-Term)

Catalog No. ABIN2778891

This Rabbit Polyclonal antibody specifically detects HNRNPU in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig and Horse.

Quick Overview for HNRNPU antibody (C-Term) (ABIN2778891)

Target: HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNRNPU antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HNRNPU Antibody

Binding Specificity: C-Term

Sequence: EITYVELQKE EAQKLLEQYK EESKKALPPE KKQNTGSKKS NKNKSGKNQF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HNRNPU. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HNRNPU

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 825 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HNRNPU

Target: HNRNPU (Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))

Alternative Name: HNRNPU

Background: HNRNPU belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. HNRNPU contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. But this cleavage does not affect the function of the encoded protein in RNA metabolism.
Alias Symbols: HNRPU, SAF-A, U21.1, hnRNP U
Protein Interaction Partner: FBXW11, FUS, HUWE1, BTRC, UBC, TUBG1, TP53, AURKA, MAGED2, TUBGCP3, CEP57, AURKB, SUMO2, SUMO3, CEP70, CEP76, MDM2, LGALS3BP, EMD, HAUS2, TUBGCP4, CEP250, NEDD1, STAU1, IVNS1ABP, LGR4, ERG, RPA3, RPA2, RPA1, WWOX, RNF2, SHFM1, EED, rev, RPS29, RPS27, RPS6
Protein Size: 825

Molecular Weight: 90 kDa

Gene ID: 3192

NCBI Accession: NM_031844, NP_114032

UniProt: Q00839