Hexamethylene Bis-Acetamide Inducible 1 Proteins (HEXIM1)

Expression of HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. Additionally we are shipping HEXIM1 Antibodies (139) and HEXIM1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HEXIM1 10614 O94992
HEXIM1 192231 Q8R409
HEXIM1 498008 Q5M9G1
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Top HEXIM1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
Yeast Xenopus laevis His tag   1 mg 60 to 71 Days
Yeast Zebrafish His tag   1 mg 60 to 71 Days
Yeast Cow His tag   1 mg 60 to 71 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Escherichia coli (E. coli) Human His tag   1 mg 2 to 3 Days
Human Un-conjugated   1 mg 6 Days

HEXIM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) Interaction Partners

Human Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) interaction partners

  1. Both HEXIM1 and RAD51 promote BET inhibitor-induced fork slowing but also prevent a DNA damage response.

  2. The 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). And in addition to its action on P-TEFb, it plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets.

  3. We conclude that the degradation of NPM1 and HEXIM1 through autophagy in certain AML subsets contributes to the activation of the BET pathway in these cells.

  4. Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway.

  5. HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis.

  6. HSP70 activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 activators

  7. Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues.

  8. Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 expression, and mild SMAD7 expression play important roles in the progression of prostate adenocarcinoma.

  9. Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes.

  10. Data indicate the binding of RNA-binding protein HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE and LARP7.

  11. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP.

  12. This study demonstrates a novel role of HEXIM1 in regulating human pluripotent stem cells fate through a P-TEFb-independent pathway.

  13. HEXIM1 functions as an AR (androgen receptor) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation.

  14. the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2

  15. There is evidence for a direct interaction between HIF-1alpha and HEXIM1, and HEXIM1 up-regulated hydroxylation of HIF-1alpha.

  16. P-TEFb/HEXIM1-dependent transcriptional regulation may play a pathophysiological role in RVH and be a novel therapeutic target for mitigating RVH in PAH

  17. results not only identify HEXIM1 as a positive regulator of p53, but also propose a novel molecular mechanism of p53 activation caused by the anti-cancer drugs and compounds.

  18. Changes in Hexim-1 protein expression and cellular distribution significantly influence androgen receptor activation and transforming growth factor (TGF)-beta signaling in prostate cancer progression.

  19. N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat.

  20. Structural insights were provided into the recognition of the regulator protein Hexim1 by P-TEFb and the modulation of coiledcoil dynamics by specific discontinuities.

Cow (Bovine) Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) interaction partners

  1. The authors demonstrate that bovine hexamethylene bisacetamide-induced protein 1 (BHEXIM1) inhibits the bovine immunodeficiency virus-mediated BIV LTR transcription. In vivo and in vitro assays show direct binding of BHEXIM1 to the bovine cyclin T1.

Mouse (Murine) Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) interaction partners

  1. Trypanosoma cruzi (T. cruzi) infected mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene have compromised cardiac function, altered expression of both pro- and anti-inflammatory cytokines, and increased inflammation and fibrosis. The profound exacerbation of pathologic findings in the tissues of heart, lung, spleen, and intestines suggests a protective role for Hexim1 in T. cruzi infection.

  2. Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 respectively.

  3. Hexim1 selectively modulates leptin-mediated signal transduction pathways in the hypothalamus.

  4. conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition

  5. HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy

  6. re-expression of HEXIM1 in mammary epithelial cells resulted in inhibition of metastasis to the lung

  7. a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.

  8. Our findings underscore the critical role of CLP-1 in remodeling of the genetic response during hypertrophy and fibrosis.

  9. these results show that the improvement in cardiac function in CLP-1(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling.

  10. CLP-1 and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy

  11. HEXIM1 plays critical roles in coronary vessel development and myocardial growth

  12. the reduced level of CLP-1 introduced in the background of elevated levels of cyclin T1 elevates derepression of P-TEFb activity and emphasizes the importance of the role of CLP-1 in the mechanism governing compensatory hypertrophy in cardiomyocytes.

HEXIM1 Protein Profile

Protein Summary

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.

Gene names and symbols associated with HEXIM1

  • hexamethylene bisacetamide inducible 1 (HEXIM1)
  • hexamethylene bis-acetamide inducible 1 (hexim1)
  • hexamethylene bis-acetamide inducible 1 (Hexim1)
  • hexamethylene bis-acetamide inducible 1 L homeolog (hexim1.L)
  • 7330426E13Rik protein
  • Clp-1 protein
  • Clp1 protein
  • EDG1 protein
  • fd44h02 protein
  • hexim protein
  • HEXIM1 protein
  • HIS1 protein
  • MAQ1 protein
  • wu:fd44h02 protein
  • zgc:162976 protein

Protein level used designations for HEXIM1

hexamethylene bis-acetamide inducible 1 , HMBA-inducible , protein HEXIM1 , protein HEXIM1-like , protein HEXIM , cardiac lineage protein 1 , estrogen down-regulated gene 1 protein , hexamethylene bis-acetamide-inducible protein 1 , hexamethylene bisacetamide-inducible protein , hexamethylene-bis-acetamide-inducible transcript 1 , hexamthylene bis-acetamide inducible 1 , menage a quatre 1 , menage a quatre protein 1 , HMBA-inducible 1

454746 Pan troglodytes
716006 Macaca mulatta
100339675 Oryctolagus cuniculus
100601526 Nomascus leucogenys
562319 Danio rerio
10614 Homo sapiens
606811 Canis lupus familiaris
539696 Bos taurus
192231 Mus musculus
498008 Rattus norvegicus
735111 Xenopus laevis
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