Hippocalcin Proteins (HPCA)

The protein encoded by HPCA is a member of neuron-specific calcium-binding proteins family found in the retina and brain. Additionally we are shipping Hippocalcin Antibodies (48) and Hippocalcin Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HPCA 3208 P84074
HPCA 15444 P84075
HPCA 29177 P84076
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Top Hippocalcin Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human HPCA Protein. 100 μg 11 to 18 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Yeast Cow His tag   1 mg 60 to 71 Days

HPCA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Hippocalcin (HPCA) Interaction Partners

Human Hippocalcin (HPCA) interaction partners

  1. Sequence analysis of the HPCA gene in 505 patients with dystonia did not reveal variants in the coding regions of HPCA.

  2. hippocalcin forms oligomers upon calcium binding and directly interacts with VGCCs. The dystonia-causing mutations did not affect protein stability or folding. In common for both T71N and A190T mutants was an impaired calcium-dependent oligomerisation and increased intracellular calcium influx after KCl depolarisation.

  3. None of the patients enrolled was found to carry HPCA mutations, rising suspicion that these probably represent a very rare cause of dystonia in childhood-adolescence.

  4. Mutations in HPCA cause autosomal-recessive primary isolated dystonia.

  5. analysis of a novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents

  6. Hippocalcin is a sensitive Ca2+ sensor capable of responding to increases in intracellular Ca2+ concentration over the narrow dynamic range of 200-800 nM free Ca2+.

  7. The structural factors affecting the binding of hippocalcin to phosphatidylinositol 4,5-bisphosphate at the cell surface and the Golgi apparatus are described.

  8. Hippocalcin and MLK2 were colocalized in the halo of Lewy bodies in Parkinson disease patients, and neither protein was detected in normal pigmented neurons.

  9. diminished hippocalcin expression does not contribute to Huntington disease-related neurodegeneration

Mouse (Murine) Hippocalcin (HPCA) interaction partners

  1. neurogenic markers, including doublecortin and the neuronal nuclei antigen, and hippocalcin, otub1, and spectrin-alpha are potential molecular links between hippocampal neurogenesis and exercise in the elderly.

  2. results suggest that 7,8-Dihydroxy-4-methylcoumarin prevents glutamate-induced toxicity by scavenging free radicals and regulating hippocalcin expression.

  3. Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization

  4. Suggest that the maintenance of parvalbumin and hippocalcin levels by melatonin in ischemic injury contributes to the neuroprotective effect of melatonin against neuronal cell damage.

  5. An age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging.

  6. These results suggest that hippocalcin plays a crucial role in the Ca(2+)-signaling pathway that underlies long-lasting neural plasticity and that leads to spatial and associative memory.

  7. These results suggest that hippocalcin plays an important role in calcium extrusion from neurons and, in turn, helps to protect them against calcium-dependent excitotoxin damage in the hippocampus.

Cow (Bovine) Hippocalcin (HPCA) interaction partners

  1. hippocalcin-modulated ONE-GC transduction system exists in the olfactory receptor neuroepithelium. The Hpca-gene knock out studies demonstrate that the portion of this is about 30% of the total membrane guanylate cyclase transduction system

Hippocalcin (HPCA) Protein Profile

Protein Summary

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species.

Gene names and symbols associated with Hippocalcin Proteins (HPCA)

  • hippocalcin (hpca)
  • hippocalcin S homeolog (hpca.S)
  • hippocalcin (HPCA)
  • hippocalcin (Hpca)
  • BDR2 protein
  • MGC80408 protein
  • MGC84992 protein
  • zgc:73126 protein

Protein level used designations for Hippocalcin Proteins (HPCA)

neuron-specific calcium-binding protein hippocalcin , hippocalcin , calcium-binding protein BDR-2 , neuron specific calcium-binding protein hippocalcin , P23K , calcium-binding protein

393696 Danio rerio
446775 Xenopus laevis
733559 Xenopus (Silurana) tropicalis
746988 Pan troglodytes
3208 Homo sapiens
15444 Mus musculus
29177 Rattus norvegicus
509772 Bos taurus
100144505 Sus scrofa
419668 Gallus gallus
611787 Canis lupus familiaris
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