Histamine Receptor H4 (HRH4) ELISA Kits

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Additionally we are shipping Histamine Receptor H4 Antibodies (93) and Histamine Receptor H4 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HRH4 59340 Q9H3N8
HRH4 170704 Q91ZY1
HRH4 225192 Q91ZY2
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Top Histamine Receptor H4 ELISA Kits at antibodies-online.com

Showing 3 out of 28 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.056 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details
Mouse 0.051 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$757.89
Details
Rat 0.055 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$800.00
Details

More ELISA Kits for Histamine Receptor H4 Interaction Partners

Human Histamine Receptor H4 (HRH4) interaction partners

  1. these findings reveal that rs11662595 is a loss-of-function polymorphism that results in dysfunction of HRH4 and attenuates the anti-epithelial-to-mesenchymal transition function of HRH4 in non-small cell lung cancer (NSCLC), which provides a promising biomarker for prognosis and therapy of NSCLC.

  2. Taken together, the silencing of H4R inhibited the H4R mediated Mast cell functions and SAPK/JNK phosphorylation. Furthermore, the H4R activation utilized SAPK/JNK signaling pathway for IL-1beta release in HMC-1 cells

  3. Our novel scientific data provide further indication that histamine, in particular via the H4R, plays a potent role in the pathophysiology of allergic diseases through tight control of Th1-Th2 mediator production favoring Th2 lymphocyte accumulation in inflamed tissues. Our results add to a growing evidence of data suggesting that the H4R may serve as a therapeutic target in allergic diseases.

  4. The expression of H4R was increased in peripheral blood monocytes in rheumatoid arthritis patients. Histamine and Th17 cytokines induced the osteoclast differentiation from monocytes and JNJ7777120 decreased the osteoclastogenesis.

  5. H1R and H4R are useful biomarkers of allergic inflammation on the ocular surface. Most notably, H4R expressed on eosinophils is useful as a biomarker of eosinophilic inflammation of the ocular surface.

  6. Histamine stimulation influences the IL-17 pathway in psoriasis via the fourth histamine receptor subtype, H4R, on CD4+ T cells.

  7. This study suggests that genetic variations within the HRH4 gene might be associated with special clinical features of psoriasis.

  8. Our findings provide evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with the risk of allergic rhinitis (AR) and the efficacy of H1 antihistamines for the treatment of AR patients.

  9. These data imply that the H4R regulates IgE-dependent processes in human basophils and provides a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative feedback loop.

  10. Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells

  11. Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus

  12. Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events.

  13. We also found that the activation of H4R caused the release of IL-13 and RANTES on human mast cells.these data demonstrate that the H4R activates divergent signaling pathways to induce cytokine and chemokine production in human mast cells

  14. H4R may be involved in the maintenance of healthy oral mucosa. In oral lichen planus, this maintenance might be impaired by mast cell degranulation and inflammatory cytokines.

  15. Activation of the H4R could induce phosphorylation of ERK.

  16. Suggest roles for HRH4 polymorphisms and ankylosing spondylitis susceptibility.

  17. H4 receptor expression plays a role in pathological vessel leakage associated with choroidal neovascularization

  18. Molecular modelling studies, including molecular dynamic simulations and calculation of Gibbs energy of solvation of hH3R and hH4R, were studied.

  19. Functional H4 receptors increasing (35)S-GTPgammaS binding and/or decreasing noradrenaline release are not found in human, guinea pig or mouse cortex

  20. HRH4 was increased in clinically-isolated syndrome and different stages of multiple sclerosis compared to health control.

Mouse (Murine) Histamine Receptor H4 (HRH4) interaction partners

  1. Study results indicate that persistent ERK activation via the histamine H4 receptor in spinal neurons underlies dinitrofluorobenzene-induced chronic itch.

  2. Results suggest that TNF-alpha mRNA expression via histamine H4 receptors may contribute to the development of cisplatin-induced anorexia, and that histamine H4 receptor antagonists are potentially useful treatments.

  3. colonic mast cells-derived histamine initiates granulocyte infiltration into the colonic mucosa through H4R

  4. This study demonstrated that the phenotype of H4R(-)/(-) mice leads to increased neuropathic pain hypersensitivity promoting an overactivation of spinal ERK-CREB pathway in DbetaH expressing neurons without modifying the innervation of the hind paw skin and integrity of the primary sensory neurons.

  5. H4R ligands have a beneficial effect in a model of lung fibrosis in the mouse, thus indicating that H4R antagonists or inverse agonists could be a novel therapeutic strategy for lung inflammatory diseases.

  6. Results illustrate that histamine H4 receptors (H4R) modulates various neurophysiological functions such as locomotor activity, anxiety, nociception and feeding behaviour, confirming the importance of the integrity and functionality of neuronal H4R in the histaminergic regulation of neuronal functions.

  7. These results identify the H4R as a new target controlling NK cell migration and NK cell-dendritic cell interaction in the skin during early allergic inflammation. These results further suggest that blocking the H4R in the skin might be beneficial in diseases like atopic dermatitis.

  8. Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis

  9. H4 receptor expression plays a role in pathological vessel leakage associated with choroidal neovascularization

  10. These results indicate a proinflammatory role of histamine via H4R in inflammatory bowel disease.

  11. Functional H4 receptors increasing (35)S-GTPgammaS binding and/or decreasing noradrenaline release are not found in human, guinea pig or mouse cortex

  12. in experimental asthma in mice the H4 receptor specifically regulates activation of dendritic cells during sensitization, while in the effector phase the H4 receptor is active in cells involved in the activation of eosinophils, and possibly other cells.

  13. involved in the pathogenesis and progression of rheumatoid arthritis

  14. These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation.

  15. the role of H4 receptors in immune disease is context-specific, depending on the animal model used and the complement of H4 receptor-expressing cells; H4 receptor blockade was detrimental in experimental autoimmune encephalomyelitis

  16. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.

  17. H4R expression on murine keratinocytes was detected after stimulation with LPS and peptidoglycan.

  18. HR4 is most important for the development of rheumatoid arthritis.

  19. the present study shows that H4 receptors potentially play a role in IgE induced FcepsilonRI upregulation

  20. Acting via its H4 receptors, histamine impedes lipopolysaccharide-induced microglia migration and interleukin (IL)-1beta release under inflammatory challenge.

Guinea Pig Histamine Receptor H4 (HRH4) interaction partners

  1. Functional H4 receptors increasing (35)S-GTPgammaS binding and/or decreasing noradrenaline release are not found in human, guinea pig or mouse cortex

Histamine Receptor H4 (HRH4) Antigen Profile

Antigen Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Histamine Receptor H4 (HRH4) ELISA Kits

  • histamine receptor H4 (HRH4) antibody
  • histamine receptor H4 (Hrh4) antibody
  • AXOR35 antibody
  • BG26 antibody
  • GPCR105 antibody
  • GPRv53 antibody
  • H4 antibody
  • H4R antibody
  • HH4R antibody
  • HRH4 antibody

Protein level used designations for Histamine Receptor H4 (HRH4) ELISA Kits

G-protein coupled receptor 105 , SP9144 , histamine H4 receptor , pfi-013 , H4R , HH4R , histamine receptor H4 , histamine 4 receptor , histamine H4 receptor-like

GENE ID SPECIES
59340 Homo sapiens
170704 Rattus norvegicus
225192 Mus musculus
397224 Sus scrofa
468501 Pan troglodytes
490512 Canis lupus familiaris
702044 Macaca mulatta
769106 Gallus gallus
783354 Bos taurus
100034111 Equus caballus
100358525 Oryctolagus cuniculus
100379272 Cavia porcellus
100442858 Pongo abelii
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