Histidine Decarboxylase (HDC) ELISA Kits

HDC encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Additionally we are shipping Histidine Decarboxylase Antibodies (76) and Histidine Decarboxylase Proteins (18) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HDC 3067 P19113
HDC 15186 P23738
HDC 24443  
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Top Histidine Decarboxylase ELISA Kits at antibodies-online.com

Showing 4 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Rat 7.8 pg/mL 31.2-2000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
Human 0.7 ng/mL 2.343 ng/mL - 150 ng/mL 96 Tests 15 to 17 Days
Mouse < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests 11 to 18 Days
  96 Tests 15 to 18 Days

More ELISA Kits for Histidine Decarboxylase Interaction Partners

Human Histidine Decarboxylase (HDC) interaction partners

  1. Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review]

  2. a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population

  3. Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors.

  4. The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer.

  5. HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure

  6. Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome.

  7. HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR, SHP, and CDX1.

  8. Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils.

  9. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase.

  10. crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees

  11. It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction.

  12. The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed.

  13. Variants in the HDC gene may play little or no role in Tourette Syndrome susceptibility in Chinese Han population.

  14. Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase.

  15. The histidine decarboxylase allele Glu644 in homozygosity increases the risk of developing rhinitis in the studied population

  16. identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics

  17. the elevation of HDC expression during human monocytic differentiation

  18. HDC expression is regulated by gastrin through a complex cis-acting element, which binds at least three distinct nuclear factors

  19. Histidine decarboxylase promoter activity can be repressed by kruppel-like factor 4

  20. histidine decarboxylase mRNA is found in human vascular smooth muscle and endothelial cells

Mouse (Murine) Histidine Decarboxylase (HDC) interaction partners

  1. Hdc(-/-) high-fat diet (HFD) mice had increased steatosis compared with WT HFD mice. WT HFD mice had increased biliary mass, biliary proliferation, senescence, fibrosis, and hepatic stellate cell activation, which were reduced in Hdc(-/-) HFD mice. In Hdc(-/-) HFD mice, serum leptin levels increased, whereas biliary Ob-R expression decreased.

  2. The results of this study indicated that Hdc deficiency in mice does not disturb the development of striatal and cortical interneurons and does not lead to the morphological and cytological phenotypes characterized by humans with Guilles de la Tourette syndrome.

  3. Genetic abnormalities in histaminergic signaling may produce a vulnerability to inflammatory challenge, setting the state for pathogenically dysregulated neuroimmune responses.

  4. The H3 receptor is upregulated in the striatum in the Hdc KO mouse model of tic disorders.

  5. Lack of endogenous histamine in NOD HDC(-/-) mice decreased the incidence of diabetes in relation to their wild-type counterpart.

  6. the structure and function of the retina in mice that lacked expression of the rate limiting enzyme in the formation of histamine, histidine decarboxylase (Hdc-/- mouse), were investigated.

  7. SDS induces itch through increased production of epidermal histamine, which results from an increase in the gene expression and post-translation processing of L-histidine decarboxylase.

  8. HDC, whose expression is remarkably downregulated during the first few days after birth in dermal cells of mice, plays essential roles in the hair-inducing ability of newborn mouse dermal cells

  9. An increased expression of H3 receptors in HDC KO mice without any changes in the spontaneous firing of "histaminergic" neurons without histamine and their responses to the H3 receptor agonist (R)-alpha-methylhistamine.

  10. Histidine decarboxylase was found at comparably high levels in mouse striatum.

  11. There was no difference in the levels of vascular endothelial growth factor between HDC-/- or wild-type mice, either in the lung or in bronchoalveolar-lavage cells.

  12. The absence of histamine adversely affects splenic hematopoiesis via direct and indirect mechanisms

  13. HDC-/- mice showed reduced severity of K/BxN serum-induced arthritis.

  14. Targeted deletion of this gene in mice increases bone formation and protects against ovariectomy-induced bone loss.

  15. in 12 day old embryonic stem cells histidine decarboxylase was confined to peripheral cells and small clusters of cells, inner cells were usually negative for it

  16. Metabolic phenotype of mice lacking histamine due to targeted disruption of histidine decarboxylase. Characterized by visceral adiposity, increased of brown adipose tissue, impaired glucose tolerance, hyperinsulinemia, and hyperleptinemia.

  17. histidine decarboxylase has a role in CYP2E1 and CYP3A activity, but not in CYP1A and CYP2B activity

  18. We hypothesize that during the chronic phase of infection elevated HDC levels, possibly of mast cell origin, are associated with Th2-dominated responses and serious disease development.

  19. In HDC-deficient mice, development of amygdaloid kindling is significantly accelerated and duration of afterdischarge and generalized seizure is prolonged, compared to wild-type mice.

  20. self-antigen binding repertoires of natural autoantibodies in histidine decarboxylase knock-out mice, unable to synthesize histamine

Fruit Fly (Drosophila melanogaster) Histidine Decarboxylase (HDC) interaction partners

  1. genes encoding for proteins involved in histamine signaling [histidine decarboxylase (hdc), histamine-gated chloride channel subunit 1 (hisCl1), ora transientless (ort)] cause abnormal temperature preferences

Zebrafish Histidine Decarboxylase (HDC) interaction partners

  1. Ethanol upregulates histidine decarboxylase expression in neural brain networks.

Histidine Decarboxylase (HDC) Antigen Profile

Antigen Summary

This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.

Gene names and symbols associated with HDC

  • histidine decarboxylase (HDC) antibody
  • histidine decarboxylase (Hdc) antibody
  • Histidine decarboxylase (Hdc) antibody
  • histidine decarboxylase (LOC548615) antibody
  • histidine decarboxylase (hdc) antibody
  • histidine decarboxylase (Desac_2880) antibody
  • histidine decarboxylase (LOC100313635) antibody
  • histidine decarboxylase (LOC100533309) antibody
  • 4732480P20 antibody
  • anon-WO0140519.259 antibody
  • AW108189 antibody
  • CG3454 antibody
  • Dmel\\CG3454 antibody
  • HDC antibody
  • Hdc-a antibody
  • Hdc-c antibody
  • Hdc-e antibody
  • Hdc-s antibody
  • JK910 antibody
  • LOC100313635 antibody

Protein level used designations for HDC

L-histidine decarboxylase , CG3454-PA , CG3454-PB , CG3454-PC , Hdc-PA , Hdc-PB , Hdc-PC , histidine decarboxylase , histidine-decarboxylase , histidine decarboxylase-like

3067 Homo sapiens
15186 Mus musculus
24443 Rattus norvegicus
36076 Drosophila melanogaster
415454 Gallus gallus
453425 Pan troglodytes
487551 Canis lupus familiaris
515950 Bos taurus
548615 Strongylocentrotus purpuratus
715287 Macaca mulatta
793609 Danio rerio
10438116 Desulfobacca acetoxidans DSM 11109
100313635 Saccoglossus kowalevskii
100407107 Callithrix jacchus
100435706 Pongo abelii
100533309 Aplysia californica
100583943 Nomascus leucogenys
100156724 Sus scrofa
100719978 Cavia porcellus
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