Histidine Triad Nucleotide Binding Protein 1 Proteins (HINT1)

Human Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

1. The c.335C>T (p.R119W) of the HINT1 gene probably underlies neuromyotonia and axonal neuropathy in this pedigree.

2. HINT1 mutations R37P, G93D and W123* destabilize the HINT1 dimer and significantly reduce catalytic activity and HINT1 inhibitor binding activity. The H112N mutant is dimeric and lacks catalytic activity, but has high affinity to AMP and a HINT1 inhibitor. Catalytic activity and dimeric structure of the surface mutants, C84R and G89V are similar to wild-type HINT1.

3. Two homozygous missense mutations in HINT1 gene were identified in two cases of axonal neuropathy with neuromyotonia.

4. the role of HINT1 neuropsychiatric disorders was summarized [review]

5. Thus, hHint1 appears to be structurally sensitive to irreversible inactivation by copper, which may be of neurotoxicological and pharmacological significance.

6. Hint1 has been shown to be essential for the metabolic activation of nucleotide antiviral pronucleotides (i.e., proTides). These results provide mechanistic insights underpinning histidine nucleophilic catalysis in general and human Hint1 catalysis, in particular, thus aiding the design of future proTides and the elucidation of the natural function of the Hint family of enzymes.

7. We provide a comprehensive overview of the structural and functional characteristics of the HINT1 protein that may guide further studies into the molecular aetiology and treatment strategies--{REVIEW}

8. Underexpression of Hint1 is associated with invasion of hepatocellular carcinoma.

9. first structure (at a 2.34A resolution) of a complex of human HINT1 with a non-hydrolyzable analog of an Ap4A dinucleotide

10. Absence of HINT1 mutations in a UK and Spanish cohort of patients with inherited neuropathies

11. In hepatocellular carcinoma, HINT1 is a regulator of IkappaBalpha through SCF(beta-TrCP) E3 ligase.

12. HINT1 mutations seem to be one of the most frequent causes of inherited neuropathy and are probably the most frequent cause of HMN in Czech patients. We suggest all HMN/CMT2 patients be tested for the presence of the prevalent mutation, the p.R37P

13. The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB.

14. Data suggest that histidine triad nucleotide binding protein 1 (HINT1) should be added to the list of genes to check for in distal hereditary motor neuropathies (dHMNs).

15. Study gives suggestive evidence that HINT1 rs3852209 may be related to smoking status in Chinese men.

16. BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue

17. Histidine triad nucleotide-binding protein 1, bifunctional aminoacyl-tRNA synthetase, and clusterin precursor protein may serve as potential biomarkers distinguishing type 2 diabetes mellitus patients from healthy controls.

18. hHint1 catalyzes the hydrolysis of phosphoramidate and acyl adenylate with high efficiency.

19. loss of functional HINT1 protein results in a distinct phenotype of autosomal recessive axonal neuropathy with neuromyotonia.

20. The results reveal the structural basis for the remarkable adenylate surveillance activity of Hint1, to potentially control Ap(4)A levels in the cell.

Mouse (Murine) Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

1. Increased PKC activity and altered GSK3B/NMDAR function drive behavior cycling in HINT1-deficient mice.

2. Study shows that social isolation to a series of schizophrenia-related deficits and that potential interactions among histidine triad nucleotide binding protein 1, NMDA receptor 1, and dopamine receptor 2 may underlie the behavioral deficits induced by social isolation.

3. The absence of Hint1 gene enhances supraspinal nociceptive sensitivity in mice, including thermal, mechanical and inflammatory hyperalgesia.

4. It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 subunits in a calcium-independent manner, whereas sigma1R binding to these proteins increases in the presence of calcium.

5. Results suggest that Hint1 deficiency leads to an increased protein level of PKC gamma in the brain and a compromised activation response of PKC gamma upon stimulation

6. HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.

7. These results further support a role for HINT1 in nicotine-mediated behaviors and suggest that alterations in the gene may have differential effects on phenotype in males and females.

8. Activated mu-opioid receptors stimulate the production of nitric oxide (NO), and the redox zinc switch RGSZ2 converts this signal into free zinc ions that are required to recruit the redox sensor PKCgamma to HINT1 proteins.

9. lipidomic phenotype of the Hint1(-/-) mouse

10. these mice do not provide a disease model or a means for investigating the basis of HINT1-associated neuropathy and neuromyotonia

11. Cannabinoids that act through CNR1 maintain the negative control of HINT1 on NMDAR function and their protection against glutamate excitotoxic insult persists.

12. our data support a role for the HINT1 gene in mediating behaviors associated with nicotine reward and physical nicotine withdrawal, and provide insight into the role of HINT1 in nicotine dependence-like behaviors.

13. Thus the study demonstrates a novel function of HINT1 that involves the regulation of store-operated channel-mediated Ca(2+) entry pathway

14. Results indicate a genetic association between HINT1 variants and ND, and indicate that nicotine-induced modulation of HINT1 level may be involved in mechanisms of excess smoking.

15. HINT1 forms homodimers in cells and that these dimers act in the cross-regulation between NMDARs and MORs.

16. Data show that through HINT1, the MOR facilitates the cross-talk of two NO- and zinc-regulated signal-transduction pathways, PKC/Src and Raf-1/ERK1/2, implicated in the negative control of morphine effects.

17. This study indicated a role for Hint1 and PKCgamma in modulating anxiety-related and stress-coping behaviour in mice.

18. Hint1 protein influences the course of hepatic ischemia/reperfusion injury, and its ablation in Kupffer cells may limit the extent of the injury.

19. widely expressed during development; pronounced expression in neuronal ganglia, epithelia, hearts, and testes from embryonic day 15 onward; deficient mice had normal life span & were apparently healthy; hint may not be a key regulator of Cdk7 activity

20. PKCI may normally play a tumor-suppressor role

Rabbit Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

1. structure of the rabbit HINT1-adenosine complex is reported at 1.10 A resolution, which is one of the highest resolutions obtained for a HINT1 structure