Histidyl TRNA Synthetase (HARS) ELISA Kits

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Additionally we are shipping Histidyl TRNA Synthetase Antibodies (70) and Histidyl TRNA Synthetase Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
HARS 3035 P12081
HARS 15115 Q61035
Anti-Rat HARS HARS 307492  
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Top Histidyl TRNA Synthetase ELISA Kits at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

More ELISA Kits for Histidyl TRNA Synthetase Interaction Partners

Human Histidyl TRNA Synthetase (HARS) interaction partners

  1. the first biochemical analysis of Charcot-Marie-Tooth-associated HARS mutations and underscores how loss of the primary aminoacylation function can contribute to disease pathology.

  2. This study suggests that the human HisRS genes, while descending from a common ancestor with dual function for both types of tRNA(His), have acquired highly specialized tRNA recognition properties through evolution.

  3. Despite the similar kinetics, differential scanning fluorimetry revealed that Y454S is less thermally stable than Wild Type HARS, and cells from Y454S patients grown at elevated temperatures demonstrate diminished levels of protein synthesis compared to those of Wild Type cells. The thermal sensitivity associated with the Y454S mutation represents a biochemical basis for understanding Usher Syndrome Type IIIB.

  4. Loss of function mutations in histidyl-tRNA synthetase cause a spectrum of inherited peripheral neuropathies

  5. Data suggest that by comparing human and trypanosomatid histidyl-tRNA synthetases (HisRS) may provide opportunities for developing specific inhibitors of Trypanosoma brucei HisRS.

  6. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis.

  7. Data indicate that higher anti-Jo1 levels were associated with disease severity in antisynthetase syndrome (ASS) patients.

  8. Non-Jo-1 anti-synAb positive patients have decreased survival compared with Jo-1 patients.

  9. Findings suggest that histidyl-tRNA synthetase (HARS) is associated with axonal peripheral neuropathy.

  10. The crystal structure of a novel splice variant of a tRNA synthetase lacking the entire catalytic domain.

  11. Although anti-Jo1 positive patients with antisynthetase syndrome share features of patients with anti-PL7/PL12 antibody, they exhibit many differences regarding clinical phenotype and long-term outcome.

  12. Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS.

  13. genomic organization of the HARS locus and mapping of transcripts originating from a bi-directional promoter controlling the differential expression of these gene

  14. Demonstrating histidyl-tRNA synthetase (Jo-1)-specific T cell responses represents a key step in establishing the hypothesis that Jo-1 drives T cell-mediated autoimmunity in Jo-1+ polymyositis.

  15. the TSG101 interaction with HRS is a crucial step in endocytic down-regulation of mitogenic signaling and this interaction may have a role in linking the functions of early and late endosomes

  16. A proteolytically sensitive conformation of HisRS exists in the lung, the target tissue associated with this autoantibody response.

  17. clinical and prognostic profiles of 45 patients displaying anti-histidyl-tRNA synthetase autoantibodies were determined

Mouse (Murine) Histidyl TRNA Synthetase (HARS) interaction partners

  1. AA 60-90 of HRS were absolutely required for in vitro as well as in vivo signaling via MyD88-dependent TLR pathways to case myositis.

Histidyl TRNA Synthetase (HARS) Antigen Profile

Antigen Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HARS

  • histidyl-tRNA synthetase (HARS) antibody
  • histidyl-tRNA synthetase (Hars) antibody
  • Dnd1 antibody
  • HARSL antibody
  • HRS antibody
  • MMHRS antibody
  • USH3B antibody

Protein level used designations for HARS

HisRS , histidine translase , histidine--tRNA ligase, cytoplasmic , hisRS , histidine tRNA ligase , histidyl-tRNA synthetase, cytoplasmic , dead end homolog 1 , Histidyl-tRNA synthetase, cytoplasmic

478034 Canis lupus familiaris
3035 Homo sapiens
15115 Mus musculus
307492 Rattus norvegicus
510937 Bos taurus
100173931 Pongo abelii
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