HARS1/Jo-1 Products
(Histidyl-tRNA Synthetase (HARS1))
Categories
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
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Featured HARS1/Jo-1 Categories
HARS1/Jo-1 Antibodies
High quality antibodies with extensive validation data.
HARS1/Jo-1 ELISA Kits
Reliable ELISA kits for a wide range of species.
HARS1/Jo-1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HARS1/Jo-1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
Cat. No.
ABIN516353
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (4)
Cat. No.
ABIN7155257
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN561226
Quantity
100 μg
Datasheet
Datasheet
Recommended HARS1/Jo-1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967424
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Analytical Method
Semi-Quantitative Competition ELISA
Validations
Cat. No.
ABIN996870
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1136755
Quantity
96 tests
Datasheet
Datasheet
Recommended HARS1/Jo-1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306360
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306358
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123338
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our HARS1/Jo-1 products
: "Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases." in: Biochimie, Vol. 106, pp. 111-20, (2014) (PubMed).: "Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20986-95, (2012) (PubMed).
: "New mortalin and histidyl tRNA synthetase isoforms point out a pitfall in proteomic analysis of Egr1 genetically modified mice." in: Proteomics, Vol. 7, Issue 2, pp. 289-98, (2007) (PubMed).
: "Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis." in: Arthritis and rheumatism, Vol. 56, Issue 8, pp. 2729-39, (2007) (PubMed).
: "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 13, pp. 7626-31, (2003) (PubMed).
Synonyms and alternative names related to HARS1/Jo-1
histidyl-tRNA synthetase (HARS), histidyl-tRNA synthetase (Hars), Dnd1, HARSL, HRS, MMHRS, USH3BProtein level used designations for HARS1/Jo-1
- HisRS
- histidine translase
- histidine--tRNA ligase, cytoplasmic
- hisRS
- histidine tRNA ligase
- histidyl-tRNA synthetase, cytoplasmic
- dead end homolog 1
- Histidyl-tRNA synthetase, cytoplasmic
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