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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes.
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Data suggest that Ki-67 (show MKI67 Antibodies) antigen proliferative index has important limitations and hhosphohistone H3 (PHH3) is an alternative proliferative marker.
This data indicates that, in the early developing human brain, HIST1H3B constitutes the largest proportion of H3.1 transcripts among H3.1 isoforms.
Data suggest TCF19 (show TCF19 Antibodies) interacts with histone 3 lysine 4 trimethylation through its plant homeodomain finger; TCF19 (show TCF19 Antibodies) expression appears to regulate gluconeogenesis in hepatocytes; TCF19 (show TCF19 Antibodies) interacts with CHD4 (show CHD4 Antibodies) causing NuRD complex recruitment to gene promoters of enzymes involved in gluconeogenesis. (TCF19 (show TCF19 Antibodies) = transcription factor 19 (show TCF19 Antibodies); CHD4 (show CHD4 Antibodies) = chromodomain helicase DNA binding protein 4 (show CHD4 Antibodies); NuRD = nucleosome-remodeling-deacetylase)
This series of 47 diffuse midline gliomas, histone H3-K27M mutation was mutually exclusive with IDH1 (show IDH1 Antibodies)-R132H mutation and EGFR (show EGFR Antibodies) amplification, rarely co-occurred with BRAF (show BRAF Antibodies)-V600E mutation, and was commonly associated with p53 (show TP53 Antibodies) overexpression, ATRX (show ATRX Antibodies) loss, and monosomy 10. Among these K27M+ diffuse midline gliomas.
Data show that histone chaperone HIRA (show HIRA Antibodies) co-localizes with viral genomes, binds to incoming viral and deposits histone H3.3 (show H3F3A Antibodies) onto these.
These experiments showed that PHF13 (show PHF13 Antibodies) binds specifically to DNA and to two types of histone H3 methyl tags (lysine 4-tri (show VANGL2 Antibodies)-methyl or lysine 4-di-methyl) where it functions as a transcriptional co-regulator.
Hemi-methylated CpGs DNA recognition activates UHRF1 (show UHRF1 Antibodies) ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 (show UHRF1 Antibodies) histone-binding site.
We describe, for the first time, the MR imaging features of pediatric diffuse midline gliomas with histone H3 K27M mutation
Approximately 30% of pediatric high grade gliomas (pedHGG) including GBM and DIPG harbor a lysine 27 mutation (K27M) in histone 3.3 (H3.3) which is correlated with poor outcome and was shown to influence EZH2 (show EZH2 Antibodies) function.
Data suggest that, during monocyte-into-macrophage differentiation, extensive trimethylation of histone H3 lysine 4 as well as histone H3 lysine 27 promotes occupancy of histone H3 at promoters of transcription factors such as HOXA (homeodomain proteins) and FOXO (forkhead transcription factors).
Histone H3.3K27M and Trp53 (show TP53 Antibodies) loss and PDGFRA (show PDGFRA Antibodies) overexpression accelerates disease onset and increases tumor invasion.
Histone H3 arginine 2 dimethylation lysine 4 trimethylation, not simply H3lysine 4 trimethylation alone, is the mark of active promoters
Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha (show PPARA Antibodies) network.
Increased levels of decondensed chromatin in both normal progenitor cells and cancer cells are associated with global loss of H3K27me3, which is linked to MYC (show MYC Antibodies) overexpression.
histone H3 phosphorylation may be a molecular signature of the activated, retinoid-controlled mRARbeta2 gene promoter
differential regulation between gene expression and histone H3 acetylation in the variable regions of the TCRbeta locus
Rb effects permanent cell cycle exit in part by maintaining trimethylation of histone H3 lysine 27 (H3K27) on cell cycle genes.
Pygo2 (show PYGO2 Antibodies) controls pattern of histone H3 hyperacetylation
Here we show that cAMP signaling regulates histone H3 phosphorylation in a cell cycle-dependent fashion, increasing it in quiescent cells but dramatically reducing it in cycling cells
Bmi1 (show BMI1 Antibodies), which methylate H3K27, were present on the HSV-1 genome during latency.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails\; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
H3 histone family, member T
, histone 3, H3
, histone H3.1t
, H3 histone family, member A
, histone 1, H3a
, histone H3.1
, histone H3/a
, histone cluster 3, H3
, histone 1, H3f
, histone H3
, histone H3.2
, histone gene complex 1