anti-Homeobox B1 (HOXB1) Antibodies

Human Homeobox B1 (HOXB1) interaction partners

1. a homozygous c.74_82dup (p.Pro28delinsHisSerAlaPro) variant was identified in one individual with double outlet right ventricle (DORV). We also identified five previously reported polymorphisms (rs35114525, rs12946855, rs14534040, rs12939811, and rs7207109) in 18 patients (12 DORV and 6 perimembranous VSD). Our study did not show any pathogenic alterations in the coding region of HOXB1 among patients with VSD.

2. This is the first disease-associated HOXB1 mutation with a likely loss-of-function effect suggesting that all HOXB1 variants reported so far also have severe impact on activity of this transcriptional regulator

3. findings revealed a novel homozygous mutation p.Arg230Trp (c.688C>T) within the HOXB1 gene of three members of a Turkish family with hereditary congenital facial paresis (HCFP3)

4. HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma.

5. The resulting phenotype includes bilateral facial palsy, hearing loss, and strabismus and correlates extensively with the previously reported Hoxb1(-/-) mouse phenotype.

6. HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to autism spectrum disorders risk

7. Hoxb1 Expression Induces Cell Fate Changes in the Trunk Neural Tube.

8. analysis of a tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations

9. Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes.

10. It is unlikely that HoxB1 plays a significant role in the genetic predisposition to autism.

11. Variation not associated with autism in an Indian population.

12. UTX directly binds to the HOXB1 locus and is required for its activation

13. HoxB1 interacts with Pax6 and enhances its transcriptional activity. This interaction was modeled on a demonstrated interaction between zebrafish Pax6 and human HoxB1.

Mouse (Murine) Homeobox B1 (HOXB1) interaction partners

1. Hoxa1 and Hoxb1 are required for pharyngeal arch artery development.

2. Hoxa1 and Hoxb1 have diverged in function through either sub- or neo-functionalization and that the HoxA1 and HoxB1 proteins are not mutually interchangeable when expressed from the Hoxa1 locus

3. provide a comprehensive account of the developmental role of Hoxb1 in patterning the vestibular system and evidence for a remarkable developmental plasticity in the descending control of reflex limb movements

4. These data suggest that Hoxb1 and Hoxa1 are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy

5. Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development.

6. Hoxb1 is required for the anterior-posterior identity of precursors that contribute to the lateral vestibular nucleus.

7. The results of this study show that ES neural differentiation and inducible Hox gene expression can be used as a sensitive model system to systematically identify Hox novel target genes.

8. identified a novel Hoxb3 binding site S3 on the Hoxb1 locus and confirmed protein binding to this site in hindbrain tissues from the Hoxb3(Tg) mutant

9. Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice

10. Hoxb1 has a role in neural crest development into glia of the peripheral nervous system

11. Results suggest that tissues are primed to express Hox genes, such as Hoxb1, early in gastrulation, concomitant with primitive streak formation and extension, and that Hox gene inducibility is transferred by cell to cell signalling.

12. results describe the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2

13. the development and maintenance of the VIIth cranial nerve is dependent upon Hoxb1, both in the neural crest-derived glia and in the facial branchiomotor neurons

14. the activity of the Hoxb1 autoregulatory enhancer depends upon multiple Prep1-Pbx1 (PM1, PM2, and PM3) and Pbx1-Hoxb1 (R1 and R3) binding sites that cooperate to modulate and spatially restrict the expression of Hoxb1 in r4 rhombomere

15. The mice expressing the Hox-B1 protein from the Hoxa1 locus, and vice versa, are essentially normal.

16. Hoxb1 contains the cis-acting elements sufficient to initiate ectopic local nuclear reorganisation and chromatin decondensation and to break Hoxd colinearity in the primitive streak region of the early embryo.

17. Hoxb1 controls cell fate specification and proliferative capacity of neural stem and progenitor cells

Zebrafish Homeobox B1 (HOXB1) interaction partners

1. Data indicate that hox genes hoxb1a and hoxb1b have separate functions in hindbrain development.

2. Hoxb1b is likely to directly regulate ppp1r14al expression in rhombomere 4.

3. Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity.