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HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain.
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the similarity of hoxb3a/Hoxa3 regulatory mechanisms reflect the shared descent of both genes from a single ancestral paralog, expression of both genes in the posterior hindbrain and spinal cord in embryo
Study revealed that HOXB4 was highly expressed in ovarian cancer cells. HOXB4 silencing enhanced the cytotoxic effect of Taxol and DDP (show TIMM8A ELISA Kits) by downregulating ABC (show ABCB6 ELISA Kits) transporters via inhibition of the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway. These results for the first time elucidated the critical roles and molecular basis of HOXB4 underlying drug resistance in ovarian cancer cells.
HOXB4 knockout led to downregulation of P-glycoprotein, multidrug resistance-associated protein 1 (show ABCC1 ELISA Kits) and breast cancer resistance protein expression and PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling activity, suggesting that repression of HOXB4 might be a key point to reverse Multidrug resistance of K562/ADM (show ADM ELISA Kits) cells.
This study provides novel evidences of the mechanisms integrating Notch (show NOTCH1 ELISA Kits) and TNF-alpha (show TNF ELISA Kits) signaling in the transcriptional induction of GATA3 (show GATA3 ELISA Kits) and HOXB4.
Increased expression of HOXB4 in human embryonic stem cells enhances the production of hematopoietic Progenitors but does not effect the maturation of red blood cells.
The analysis of HOX (show MSH2 ELISA Kits) expression in primary mesothelioma tumors indicated that these cells could also be sensitive to the disruption of HOX (show MSH2 ELISA Kits) activity by HXR9, and that the expression of HOXB4 is strongly associated with overall survival
HOXA4 increases short-term repopulation to higher levels than HOXB4, which may involve Notch (show NOTCH1 ELISA Kits) signaling to induce self-renewal of primitive hematopoietic cells
showed that OAC1 treatment led to OCT4 (show POU5F1 ELISA Kits)-mediated upregulation of HOXB4
decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML (show RUNX1 ELISA Kits), while increased DNA methylation at DCC (show DCC ELISA Kits) distinctive to the high-risk AML (show RUNX1 ELISA Kits) was associated with increased gene expression
Epigenetic analysis revealed that increased promoter methylation of HOXB4 correlates with decreased expression of its transcript in oral cancer cell lines. HOXB4 may work as an epigenetic biomarker gene.
Our study demonstrates for the first time the regulation of HOXB4 by miR (show MLXIP ELISA Kits)-23a
Our data reveal a route to establishing functional multipotent HSCs that exploits aspects of in vitro differentiation, transcription factor re-specification with HoxB4 to enhance self-renewal, and Notch (show NOTCH1 ELISA Kits)-mediated lineage specification
can amplify long-term repopulating hematopoietic stem cells in a controlled way. This characteristic depends on a proline-rich sequence near the N terminus, which is unique among HOX (show MSH2 ELISA Kits) genes and highly conserved in higher mammals
Data suggest that the homeobox B4 protein (HoxB4) and signal transducer and activator of transcription 3 (STAT3 (show STAT3 ELISA Kits)) signals are functionally redundant for hematopoietic stem cells (HSCs) self-renewal rather than exerting independent effects.
these studies define the transcriptional pathways involved in HOXB4 HSC expansion in vivo and identify repression of Prdm16 (show PRDM16 ELISA Kits) transcription as a mechanism by which expanding HSCs avoid leukemic transformation.
Hoxb4 favours the maintenance and increase of the CD4 (show CD4 ELISA Kits) central memory phenotype T cell population.
The results show a novel role for DNA methylation in the alternative promoter usage at the Runx1 (show RUNX1 ELISA Kits) locus and identify HOXB4 as a direct activator of the Runx1 (show RUNX1 ELISA Kits) P1 promoter.
Loss of Scmh1 caused derepression of Hoxb4 and Hoxa9, direct targets of Polycomb-group complex 1-mediated transcriptional silencing in hematopoietic cells.
HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation.
HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing hematopoietic stem cells into repopulating cells
Hoxb4 expression therefore would not appear to correlate with the cycling status of fetal liver hematopoietic stem cells(HSCs), although highly proliferative HSCs from young BM show strong Hoxb4 expression.
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
, homeo box B4
, hox4 protein
, hoxb4a protein
, Hoxb4a variant 2
, homeobox gene B-4
, homeobox protein Hox-B4a
, homeobox protein Zf-13
, homeo box 2F
, homeobox protein Hox-2.6
, homeobox protein Hox-2F
, homeobox protein Hox-B4
, homeobox protein Hox-Z