anti-Homer Homolog 3 (Drosophila) (HOMER3) Antibodies

HOMER3 encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. Additionally we are shipping HOMER3 Proteins (8) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HOMER3 9454 Q9NSC5
HOMER3 26558 Q99JP6
HOMER3 29548 Q9Z2X5
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Top anti-HOMER3 Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HOMER3 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-HOMER3 Antibody Titration: 1.0 ug/ml Positive Control: Hela Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of HOMER3 using anti-HOMER3 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat brain tissue lysate, Lane 2: mouse brain tissue lysate, Lane 3: human U-87MG whole Cell lysate, Lane 4: human Hela whole Cell lysate, Lane 5: human Jurkat whole Cell lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-HOMER3 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for HOMER3 at approximately 45KD. The expected band size for HOMER3 is at 40KD. IHC analysis of HOMER3 using anti-HOMER3 antibody . HOMER3 was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-HOMER3 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of HOMER3 Antibody (Center) (ABIN652274) in MDA-MB231 cell line lysates (35 µg/lane).HOMER3 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of HOMER3 Antibody (Center) (ABIN652274) in mouse NIH-3T3 cell line lysates (35 µg/lane).HOMER3 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of HOMER3 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane).HOMER3 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of HOMER3 Antibody (Center) in NIH-3T3 cell line lysates (35ug/lane).HOMER3 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: HOMER3 Antibody [NBP2-32607] - Immunofluorescent staining of human cell line A-431 shows positivity in plasma membrane & cytoplasm. Immunohistochemistry: HOMER3 Antibody [NBP2-32607] - cerebellum 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen:   0.2 μg 100 μL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000, Secondary: HRP conjugated Goat-Anti-Rabbit IgG (ABIN727474-HRP) at 1:5000, TMB (C-0024) staining, Read the data in MicroplateReader by 450 A549 lysate probed with Rabbit Anti-HOMER3 (Thr36) Polyclonal Antibody  at 1:5000 90min in 37˚C. 100 μL Log in to see 3 to 7 Days
$328.90
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of HOMER3 Antibody in MDA-MB231 cell line lysates (35ug/lane) Western blot analysis of HOMER3 Antibody in mouse NIH-3T3 cell line lysates (35ug/lane) 400 μL Log in to see 2 to 3 Days
$515.63
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 50 μg Log in to see 11 to 14 Days
$727.83
Details

Top referenced anti-HOMER3 Antibodies

  1. Rat (Rattus) Polyclonal HOMER3 Primary Antibody for ICC, IHC - ABIN1742342 : Tao-Cheng, Thein, Yang, Reese, Gallant: Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. in Neuroscience 2014 (PubMed)

  2. Human Polyclonal HOMER3 Primary Antibody for FACS, IHC (p) - ABIN652274 : Norton, Williams, Williams, Spurlock, Zammit, Jones, Jones, Owen, ODonovan, Owen: Mutation screening of the Homer gene family and association analysis in schizophrenia. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003 (PubMed)
    Show all 2 Pubmed References

More Antibodies against HOMER3 Interaction Partners

Human Homer Homolog 3 (Drosophila) (HOMER3) interaction partners

  1. Homer3 acts as a scaffold that spatially organizes actin assembly to support neutrophil polarity and motility downstream of GPCR activation.

  2. Interaction of the protein with amyloid precursor protein (show APP Antibodies) is regulated by calcium homeostasis.

  3. Loss of Homer3 is associated with acute myeloid leukemia (show BCL11A Antibodies).

  4. Homer3 specifically associates with a novel ubiquitin-like domain in the I kappa B kinase (IKK) beta (show IKBKB Antibodies) subunit (show POLG Antibodies) of the IKK (show CHUK Antibodies) complex.

  5. Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta (show CEBPB Antibodies).

  6. Fat1 (show FAT1 Antibodies) exhibit co-localisation with Homer-3 in cellular protrusions and at the plasma membrane of HeLa cells

  7. study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin

Mouse (Murine) Homer Homolog 3 (Drosophila) (HOMER3) interaction partners

  1. impaired mTORC1-Homer-3 activity underlies PC susceptibility in Spinocerebellar ataxia type 1 and presents a promising therapeutic target

  2. Expression of Homer (show HOMER1 Antibodies) 3a/b is restricted to the developing cerebellum, hippocampus, and neonatal olfactory bulb, and is concentrated in the dendritic spines of Purkinje cells and their axons.

  3. study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin

  4. Homer2 (show HOMER2 Antibodies) and Homer3 proteins interact specifically with amyloid precursor protein (APP (show APP Antibodies)) by inhibiting APP (show APP Antibodies) processing and reducing secretion of Abeta (show APP Antibodies) peptides.

  5. Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII (show CAMK2G Antibodies) phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity.

HOMER3 Antigen Profile

Protein Summary

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with HOMER3

  • homer scaffolding protein 3b (homer3b) antibody
  • homer scaffolding protein 3 (HOMER3) antibody
  • homer scaffolding protein 3 (Homer3) antibody
  • AW146114 antibody
  • HOMER-3 antibody
  • Vesl-3 antibody
  • VESL3 antibody
  • zgc:55557 antibody

Protein level used designations for HOMER3

homer protein homolog 3 , Homer, neuronal immediate early gene, 3 , homer homolog 3 (Drosophila) , homer, neuronal immediate early gene, 3 , homer-3 , VASP/Ena-related gene up-regulated during seizure and LTP 3

GENE ID SPECIES
394088 Danio rerio
736171 Pan troglodytes
100605039 Nomascus leucogenys
9454 Homo sapiens
26558 Mus musculus
29548 Rattus norvegicus
420115 Gallus gallus
484813 Canis lupus familiaris
508124 Bos taurus
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