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Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010].. Additionally we are shipping HCN2 Antibodies (91) and HCN2 Proteins (6) and many more products for this protein.
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beta2-adrenoceptors alone strongly enhanced the activity of HCN2 channels, and co-expression of odorant receptors further diversified the HCN2 channel activity.
TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels.
HCN2 has a role in maturation and processing of the amyloid precursor protein (show APP ELISA Kits)
promoter methylation status does not appear to be a major determinant of HCN2 expression in normal and adenoid cystic carcinoma ( ACC )tissues. HCN2 hypomethylation is a biomarker of ACC and may play an important role in the carcinogenesis of ACC.
Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm.
Data show that Rab8b (show RAB8B ELISA Kits)-interacting protein TRIP8b does not compete with cyclic AMP (show APRT ELISA Kits) for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2).
N-glycosylation is not required for HCN2 channels to function.
Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels.
Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.
HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri (show PLIN1 ELISA Kits)-implantitis.
the increased intracellular cAMP drives diabetes-associated pain by facilitating HCN2 activation and consequently promoting repetitive firing in primary nociceptive nerve fibers.
The data of this study strongly suggest that cAMP acts by PKA-mediated regulation of HCN2 channel activity and thereby generates nociceptive sensitization.
Data support a model in which the degree of facilitation of opening in the full-length HCN2 channel by a given ligand depends upon its ability to promote oligomerization of the C-linker/cyclic nucleotide-binding domain in solution.
Mouse HCN2-expressing human mesenchymal stem cells are relevant biological models for the generation of biological pacemakers.
the allosteric mechanism of different cyclic nucleotides on the cyclic nucleotide-binding domain of HCN2 and on channel gating, was investigated.
HCN1, HCN2, and HCN4 subunits may have distinct physiological roles in the developing hippocampus.
HCN2 channel activity reduces the repolarization reserve of the ventricular action potential and increases ectopic automaticity under pathological conditions such as excessive beta-adrenergic stimulation.
This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
fisetin is a partial agonist for HCN2 channels.
HCN2 channel expression increases significantly during pregnancy, accelerating the heart rate.
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.
hippocampus abundant transcript 1
, hippocampus abundant transcript 1 protein
, hyperpolarization activated cyclic nucleotide-gated potassium channel 2
, brain cyclic nucleotide gated channel 2
, brain cyclic nucleotide-gated channel 2
, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
, hyperpolarization-activated cation channel 1