anti-IKAROS Family Zinc Finger 2 (IKZF2) Antibodies

Human IKAROS Family Zinc Finger 2 (IKZF2) interaction partners

1. Results indicate that downregulation of Helios mRNA, protein expression and signaling may modulate the development of neurological disorders in children with autism spectrum disorder (ASD). Results provide evidence that immune dysfunction is associated with downregulation of Helios expression in children with ASD.

2. The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability.

3. Helios mRNA is down-regulated in Treg cells of patients with hypertension.

4. mRNA expression of Helios was decreased in CD4+ T cells from patients with acute coronary syndrome.

5. High expression of TIGIT and Helios identifies CD4+ T cells with impaired immunological functions, primarily among patients with an advanced stage of Sezary syndrome.

6. revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 in T cells, such as Raptor, CHEK1, CREB1, RUNX1, SATB1, Ikaros, and Helios.

7. this study shows that Ikaros undergoes a transient increase in protein levels at the transitional single-positive CD8+ developmental stage before diverging in their expression patterns at later stages

8. The results show that high vs. low expression of Nrp-1 or Helios does not unequivocally identify Treg clones of thymic or peripheral origin.

9. Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1.

10. expression is not affected in diGeorge syndrome

11. Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.

12. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.

13. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros promoted T-cell growth.

14. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.

15. large number of ex vivo expanded functional Treg can be obtained from long-term T1D patients, although fewer expanded Treg expressed a high level of Helios

16. A differential role for monocyte subsets in control of Helios(+/-) Treg development that is mediated by distinct inflammatory cytokines.

17. Although Ikaros and Helios belong to the same family with similar structure of zinc fingers, their isoforms have different expression profiles, specific genetic alterations, and different clinical relevance in patients with leukemia.

18. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.

19. Presence of Helios-positive regulatory T (Treg) cells may maintain susceptibility to helminth infection on the C57BL/6 mouse background.

20. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.

Mouse (Murine) IKAROS Family Zinc Finger 2 (IKZF2) interaction partners

1. These data provide a genetic basis for the unstable phenotype of Helios-deficient Tregs within the inflammatory environment of tumors and suggest that immune milieu-dependent alterations in gene expression are a central feature of Treg conversion.

2. He is involved in the correct development of a subset of striatopallidal medium spiny neurons.

3. Helios controls certain aspects of Treg-suppressive function, differentiation, and survival.

4. this study reports that impaired expression of the transcription factor Helios by FoxP3+ CD4 and Qa-1-restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice.

5. data suggest that a subset of DN T cells, identified by the expression of PD-1 and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 loss as a process associated with self-Ag encounter

6. results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen

7. identify Helios as the first marker known to diverge during positive and negative selection of thymocytes

8. Helios regulates IL-2 production in Tregs by suppressing Il2 gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 locus.

9. Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons.

10. In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass.

11. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.

12. down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription factor in NK cells

13. Data show that Helios is selectively upregulated in CD4 T cells during Th2 and TFh responses to alum-protein vaccines in vivo, independently of Foxp3 expression.

14. show that Helios is upregulated in CD4(+)CD25(+) regulatory T cells.

15. silencing of Helios is critical for normal B cell function

16. results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non-DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage

17. the NuRD complex makes major contributions to the functions of both Ikaros and Helios and the activities of these proteins may be regulated in part by changes in phosphorylation

18. Helios is not essential for T cells; its function can be compensated for by other members of the Ikaros family.