anti-IKAROS Family Zinc Finger 2 (IKZF2) Antibodies

IKZF2 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF2 Proteins (4) and IKZF2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IKZF2 22807 Q9UKS7
IKZF2 22779 P81183
IKZF2 301476  
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Top anti-IKZF2 Antibodies at antibodies-online.com

Showing 10 out of 93 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IKZF2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Hamster PE FACS Human peripheral blood lymphocytes were stained with anti-CD4 Pacific 100 Tests Log in to see 5 to 7 Days
$417.45
Details
Human Hamster Un-conjugated FACS Human peripheral blood lymphocytes were stained with anti-CD4 Pacific 0.1 mg Log in to see 5 to 7 Days
$303.60
Details
Cow Rabbit Un-conjugated IHC, WB Human kidney WB Suggested Anti-ZNFN1A2 Antibody Titration: 5.0ug/ml ELISA Titer: 1:62500 Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Armenian Hamster FITC FACS 100 Tests Log in to see 10 to 12 Days
$375.04
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry: HELIOS Antibody [NBP2-34122] - Immunohistochemical staining of human colon shows strong nuclear positivity in glandular cells. Immunohistochemistry: HELIOS Antibody [NBP2-34122] - skin 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Armenian Hamster APC FACS 100 Tests Log in to see 10 to 12 Days
$410.76
Details
Human Armenian Hamster PE FACS 100 Tests Log in to see 10 to 12 Days
$410.76
Details
Human Armenian Hamster Pacific Blue FACS 100 Tests Log in to see 10 to 12 Days
$422.66
Details

Top referenced anti-IKZF2 Antibodies

  1. Human Monoclonal IKZF2 Primary Antibody for FACS - ABIN2749147 : Atarashi, Tanoue, Oshima, Suda, Nagano, Nishikawa, Fukuda, Saito, Narushima, Hase, Kim, Fritz, Wilmes, Ueha, Matsushima, Ohno, Olle, Sakaguchi, Taniguchi, Morita, Hattori, Honda: Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. in Nature 2013 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal IKZF2 Primary Antibody for FACS - ABIN2749084 : Pinheiro, Singh, Grant, Appleton, Sacchini, Walker, Chadbourne, Palmer, Armitage-Chan, Thompson, Williamson, Cunningham, Garden: Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog. in Immunology 2010 (PubMed)
    Show all 4 Pubmed References

More Antibodies against IKZF2 Interaction Partners

Human IKAROS Family Zinc Finger 2 (IKZF2) interaction partners

  1. mRNA expression of Helios was decreased in CD4 (show CD4 Antibodies)+ T cells from patients with acute coronary syndrome.

  2. High expression of TIGIT (show TIGIT Antibodies) and Helios identifies CD4 (show CD4 Antibodies)+ T cells with impaired immunological functions, primarily among patients with an advanced stage of Sezary syndrome.

  3. revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 in T cells, such as Raptor, CHEK1, CREB1, RUNX1, SATB1, Ikaros, and Helios.

  4. this study shows that Ikaros (show IKZF1 Antibodies) undergoes a transient increase in protein levels at the transitional single-positive CD8 (show CD8A Antibodies)+ developmental stage before diverging in their expression patterns at later stages

  5. The results show that high vs. low expression of Nrp-1 or Helios does not unequivocally identify Treg clones of thymic or peripheral origin.

  6. Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1 (show NELL1 Antibodies).

  7. Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV.

  8. The immunosuppressive enzyme IL4I1 (show IL4I1 Antibodies) expressed differentially in human induced Aiolos (show IKZF3 Antibodies)+, but not natural Helios+, FOXP3 (show FOXP3 Antibodies)+ Treg cells.

  9. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros (show IKZF1 Antibodies) promoted T-cell growth.

  10. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.

Mouse (Murine) IKAROS Family Zinc Finger 2 (IKZF2) interaction partners

  1. These data provide a genetic basis for the unstable phenotype of Helios-deficient Tregs within the inflammatory environment of tumors and suggest that immune milieu-dependent alterations in gene expression are a central feature of Treg conversion.

  2. Helios controls certain aspects of Treg-suppressive function, differentiation, and survival.

  3. this study reports that impaired expression of the transcription factor Helios by FoxP3 (show FOXP3 Antibodies)+ CD4 (show CD4 Antibodies) and Qa-1 (show H2-T23 Antibodies)-restricted CD8 (show CD8A Antibodies) Tregs results in defective regulatory activity and autoimmunity in mice.

  4. data suggest that a subset of DN T cells, identified by the expression of PD-1 (show PDCD1 Antibodies) and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 (show CD8A Antibodies) loss as a process associated with self-Ag encounter

  5. results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen

  6. identify Helios as the first marker known to diverge during positive and negative selection of thymocytes

  7. Helios regulates IL-2 (show IL2 Antibodies) production in Tregs by suppressing Il2 (show IL2 Antibodies) gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 (show IL2 Antibodies) locus.

  8. Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons.

  9. In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass.

  10. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.

IKZF2 Antigen Profile

Protein Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Gene names and symbols associated with IKZF2

  • IKAROS family zinc finger 2 (IKZF2) antibody
  • IKAROS family zinc finger 2 (ikzf2) antibody
  • IKAROS family zinc finger 2 (Ikzf2) antibody
  • si:zfos-1425h8.1 (si:zfos-1425h8.1) antibody
  • IKAROS family zinc finger 2 (Helios) (IKZF2) antibody
  • IKAROS family zinc finger 2 L homeolog (ikzf2.L) antibody
  • A730095J18Rik antibody
  • ANF1A2 antibody
  • DKFZp469N0319 antibody
  • Helios antibody
  • ikzf2 antibody
  • MGC159581 antibody
  • Zfpn1a2 antibody
  • znf1a2 antibody
  • znfn1a1 antibody
  • znfn1a1-a antibody
  • Znfn1a2 antibody

Protein level used designations for IKZF2

ikaros family zinc finger protein 2 , zinc finger DNA binding protein Helios , zinc finger protein Helios , zinc finger protein, subfamily 1A, 2 (Helios) , lymphoid transcription factor , IKAROS family zinc finger 2 (Helios) , helios , zinc finger protein Helios-like , IKAROS family zinc finger 2 , ikaros-related transcription factor

GENE ID SPECIES
22807 Homo sapiens
395309 Gallus gallus
100144703 Xenopus (Silurana) tropicalis
470634 Pan troglodytes
693521 Macaca mulatta
488510 Canis lupus familiaris
786795 Bos taurus
100050253 Equus caballus
100173311 Pongo abelii
100345499 Oryctolagus cuniculus
100403694 Callithrix jacchus
100468599 Ailuropoda melanoleuca
22779 Mus musculus
301476 Rattus norvegicus
100150224 Danio rerio
100510935 Sus scrofa
100538840 Meleagris gallopavo
373693 Xenopus laevis
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