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Members of the Ikaros (ZNFN1A1\; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002].. Additionally we are shipping IKZF4 Antibodies (46) and IKZF4 Proteins (4) and many more products for this protein.
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this study reports that IL-6 actively suppressed Eos mRNA and protein expression through miR-17
Ikaros may not be a conventional activator or repressor of defined sets of genes, but may sharpen the dynamic range of gene expression changes during developmental transitions
Eos is redundant for regulatory T cell function but plays an important role in IL-2 and IL-17 production by CD4+ conventional T cells.
Data indicate that miR-17 promotes TH17 differentiation by repressing target Ikaros Family Zinc Finger 4 (IKZF4).
We show that reprogramming is controlled by downregulation of the transcription factor Eos (Ikzf4), an obligate corepressor for Foxp3.
Data suggest that Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitor cells.
study identified Eos as a critical mediator of Foxp3-dependent gene silencing in CD4+ regulatory T cells (Tregs); Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs
IKZF4 polymorphism (rs1701704) was strongly associated with insulin autobody positivity at the time of type 1 diabetes diagnosis
Members of the Ikaros (ZNFN1A1\; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.
ikaros family zinc finger protein 4
, zinc finger protein Eos
, zinc finger protein, subfamily 1A, 4 (Eos)
, zinc finger protein, subfamily 1A, 4
, zinc finger transcription factor Eos