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Translational regulator that ensures constant high levels of translation under amino acid starvation. Additionally we are shipping IMPACT Proteins (11) and many more products for this protein.
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Data suggest that high expression of protein IMPACT homolog in non-immune cells acts as a protective mechanism against indoleamine 2,3-dioxygenase (IDO)-induced GCN2 activation, making them resistant to the amino acid-deprived environment caused by IDO.
It thus seems that lineage-specific enhancement of gene expression rather than the tandem repeat per se played a critical role in the evolution of imprinting of Impact.
segmental duplication followed by enhancement of the promoter activity is responsible for the species-specific imprinting of Impact
This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
the participation of the GCN2-IMPACT module of translational regulation in a highly controlled step in the development of the nervous system.
IMPACT ensures constant high levels of translation and low levels of CREB-2 and GADD53 in specific neuronal cells under amino acid starvation conditions.
Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).
imprinted and ancient
, imprinted and ancient gene protein homolog
, protein IMPACT
, Impact homolog (mouse)
, protein IMPACT-A
, imprinted and ancient gene protein homolog A
, Impact homolog
, RWD domain containing 5
, imprinted and ancient gene protein