Indoleamine 2,3-Dioxygenase 2 Proteins (IDO2)

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011].. Additionally we are shipping IDO2 Antibodies (129) and IDO2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDO2 169355 Q6ZQW0
IDO2 681319  
IDO2 209176  
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Top IDO2 Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$325.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse IDO2 Protein. 100 μg Log in to see 11 to 18 Days
$625.39
Details
Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 15 to 18 Days
$600.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Log in to see 4 Days
$234.03
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

IDO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Indoleamine 2,3-Dioxygenase 2 (IDO2) Interaction Partners

Human Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. This study demonstrated that IDO2 rs10109853 and rs4503083 polymorphisms are not associated with MS risk, age at onset and disease progression in Italian MS patients.

  2. High IDO2 expression is associated with Colorectal Cancer.

  3. High IDO2 expression is associated with cervical cancer.

  4. functional importance of IDO (show IDO1 Proteins) enzymes in human Crohn's disease

  5. Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1 (show IDO1 Proteins)

  6. These results demonstrate that IDO2 plays a novel role as a negative regulator of IDO1 (show IDO1 Proteins) by competing for heme-binding with IDO1 (show IDO1 Proteins).

  7. The IDO2 is now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along a relative newcomer to the kynurenine pathway field.

  8. Multiple-scattering (MS) analysis of EXAFS data on met-indoleamine 2,3-dioxygenase-2 (IDO2) and analysis of XANES have provided the first direct structural information about the axial donor ligands of the iron center for this recently discovered protein.

  9. IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. IDO2 expression is constitutively, stably expressed in steady-state conditions and may contribute to the homeostatic tolerogenic capacity of DCs.

  10. Indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase (show WARS Proteins) may play critical roles in the immune pathogenesis of chronic kidney disease.

Mouse (Murine) Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. IDO2-shRNA treatment also decreased the percentage of Tregs and T cell apoptosis in draining lymph nodes

  2. IDO (show IDO1 Proteins) is a critical regulator of acute pulmonary inflammation.

  3. Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.

  4. Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1 (show IDO1 Proteins), indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase (show TDO2 Proteins) in modulating brain activities and metabolism.

  5. The IDO2-deficient B cells lacked the ability to upregulate the costimulatory marker CD40 (show CD40 Proteins), suggesting IDO2 acts at the T-B cell interface to modulate the potency of T cell help needed to promote autoantibody production.

  6. Targeting IDO2 with a monoclonal antibody inhibits autoreactive B and T cell activation and alleviates joint inflammation in two well-characterized preclinical models of arthritis.

  7. Indoleamine-2,3-dioxygenase (IDO (show IDO1 Proteins)) production by Plasmacytoid dendritic cells (pDCs)is necessary to confer suppressive function to T-Cells, Regulatory (Tregs) in experimental autoimmune encephalomyelitis (EAE).

  8. Ido2 may be important for mouse embryo implantation and decidualization.

  9. The data showed that there is not significant effect of IDO1 (show IDO1 Proteins) or TDO2 (show TDO2 Proteins) on mortality in pneumococcal meningitis.

  10. IDO2 is critical for IDO1 (show IDO1 Proteins)-mediated T-cell regulation and exerts a non-redundant function in inflammation.

IDO2 Protein Profile

Protein Summary

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007

Gene names and symbols associated with IDO2

  • indoleamine 2,3-dioxygenase 2 (IDO2)
  • indoleamine 2,3-dioxygenase 2 (Ido2)
  • AI265623 protein
  • C230043N17Rik protein
  • Ido-2 protein
  • Indol1 protein

Protein level used designations for IDO2

indoleamine 2,3-dioxygenase 2 , indoleamine 2,3-dioxygenase 2-like , IDO-2 , indoleamine 2,3-dioxygenase-like 1 protein , indoleamine 2,3-dioxygenase-like protein 1 , indoleamine-pyrrole 2,3 dioxygenase-like 1 , indoleamine-pyrrole 2,3-dioxygenase-like protein 1

GENE ID SPECIES
100402049 Callithrix jacchus
707424 Macaca mulatta
100085939 Ornithorhynchus anatinus
100435160 Pongo abelii
100480334 Ailuropoda melanoleuca
100580956 Nomascus leucogenys
169355 Homo sapiens
482846 Canis lupus familiaris
513810 Bos taurus
681319 Rattus norvegicus
209176 Mus musculus
100056686 Equus caballus
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