Indoleamine 2,3-Dioxygenase 2 Proteins (IDO2)

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011].. Additionally we are shipping IDO2 Antibodies (112) and IDO2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDO2 169355 Q6ZQW0
IDO2 681319  
IDO2 209176  
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Top IDO2 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag   10 μg 15 to 16 Days
$325.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Human His tag 10 μg 14 to 16 Days
$285.35
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse IDO2 Protein. 100 μg 11 to 18 Days
$682.25
Details
Escherichia coli (E. coli) Rat His tag   100 μg 15 to 18 Days
$600.00
Details
Escherichia coli (E. coli) Human His tag   50 μg 4 Days
$522.50
Details

IDO2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Indoleamine 2,3-Dioxygenase 2 (IDO2) Interaction Partners

Human Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. Data suggest a strong association between the Indoleamine-2,3-Dioxygenase-2 (IDO2) inactivating Y359Stop single nucleotide polymorphism and an increased risk of familial pancreatic cancers when compared with the control group.

  2. This study demonstrated that IDO2 rs10109853 and rs4503083 polymorphisms are not associated with MS risk, age at onset and disease progression in Italian MS patients.

  3. High IDO2 expression is associated with Colorectal Cancer.

  4. High IDO2 expression is associated with cervical cancer.

  5. functional importance of IDO enzymes in human Crohn's disease

  6. Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1

  7. These results demonstrate that IDO2 plays a novel role as a negative regulator of IDO1 by competing for heme-binding with IDO1.

  8. The IDO2 is now known to catalyze the first and rate-limiting step in the catabolism of tryptophan along a relative newcomer to the kynurenine pathway field.

  9. Multiple-scattering (MS) analysis of EXAFS data on met-indoleamine 2,3-dioxygenase-2 (IDO2) and analysis of XANES have provided the first direct structural information about the axial donor ligands of the iron center for this recently discovered protein.

  10. IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. IDO2 expression is constitutively, stably expressed in steady-state conditions and may contribute to the homeostatic tolerogenic capacity of DCs.

  11. Indoleamine2,3-dioxygenase and tryptophanyl-tRNA synthetase may play critical roles in the immune pathogenesis of chronic kidney disease.

  12. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors.

  13. Data show that IDO2-specific T cells are cytotoxic effector cells that recognize and kill tumor cells.

  14. Tryptophan supplementation was able to completely restore hepatitis b virus replication in IFN-gamma- but not IFN-alpha-treated cells, which strongly argues that IDO is the primary mediator of IFN-gamma-elicited antiviral response in human hepatocytes.

  15. High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients.

  16. The pro-apoptotic activity of indoleamine 2, 3-dioxygenase is responsible for its transcriptional regulation and the modulation of its pro-apoptotic activity during death receptor activation in melanoma cells.

  17. First study to report IDO2 expression in pancreatic ductal adenocarcinoma indicating that IDO2 genetic polymorphisms do not negate interferon-gamma-inducible protein expression.

  18. IDO2 encodes a novel IDO-related tryptophan catabolic enzyme that is preferentially inhibited by D-1-methyl-tryptophan (D-1MT). IDO2 may have a distinct role in immune tolerance. Two common human genetic polymorphisms ablate IDO2 enzyme activity.

  19. This article describes the evolutionary relationships between the INDO and INDOL1 genes. The INDOL1 protein has a distinct expression pattern compared to INDO and both have the ability to catabolise tryptophan.

Mouse (Murine) Indoleamine 2,3-Dioxygenase 2 (IDO2) interaction partners

  1. Data showed that Ido2 depletion in immune cells effectively reduces lung cancer burden, indicating that Ido2 plays an important role in tumor progression and an important immune regulator in the tumor microenvironment.

  2. The current study shows that the Ido1 and Ido2 genes are imprinted and maternally expressed in mouse placentas. DNA methylation analysis demonstrates that nine CpG sites at the Ido1 promoter constitute a differentially methylated region that is highly methylated in sperm but unmethylated in oocytes

  3. IDO2-shRNA treatment also decreased the percentage of Tregs and T cell apoptosis in draining lymph nodes

  4. IDO is a critical regulator of acute pulmonary inflammation.

  5. Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.

  6. Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism.

  7. The IDO2-deficient B cells lacked the ability to upregulate the costimulatory marker CD40, suggesting IDO2 acts at the T-B cell interface to modulate the potency of T cell help needed to promote autoantibody production.

  8. Targeting IDO2 with a monoclonal antibody inhibits autoreactive B and T cell activation and alleviates joint inflammation in two well-characterized preclinical models of arthritis.

  9. Indoleamine-2,3-dioxygenase (IDO) production by Plasmacytoid dendritic cells (pDCs)is necessary to confer suppressive function to T-Cells, Regulatory (Tregs) in experimental autoimmune encephalomyelitis (EAE).

  10. Ido2 may be important for mouse embryo implantation and decidualization.

  11. The data showed that there is not significant effect of IDO1 or TDO2 on mortality in pneumococcal meningitis.

  12. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.

  13. Deletion of Ido1 and reduced mRNA expression for Ido2 neither affected the concentration of the downstream metabolites of tryptophan nor mRNA expression for downstream genes on the kynurenine pathway in inguinal lymph nodes.

  14. results provide important insights into IDO2 function by defining its pathogenic contributions to autoantibody-mediated autoimmunity.

  15. Immunohistochemical analysis in Ido1(-/-) mouse epididymis showed that Ido2 protein was extensively upregulated due to the loss of Ido1 expression.

  16. IDO-1 and IDO-2 play biologically important, contradictory roles during intracellular protozoal infection - facilitating (Toxoplasma gondii) or suppressing (Leishmania major) microbial clearance in a pathogen-specific manner.

  17. Findings implicate novel IDO related enzyme IDO2 in cancer as a result of its preferential inhibition by the D racemer of 1-methyl-tryptophan, used widely in its racemic form (D,L-1MT) as an IDO inhibitor including as an anticancer agent

  18. role in the inhibition of immune responses to tumours

  19. A second tryptophan catabolic enzyme inducible by IFNg, implicated in transcriptional immune regulation (IFNg-driven negative feedback), may limit the pro-inflammatory and anti-proliferative functions(Review)

  20. This article describes the evolutionary relationships between the INDO and INDOL1 genes. The INDOL1 protein has a distinct expression pattern compared to INDO and both have the ability to catabolise tryptophan.

IDO2 Protein Profile

Protein Summary

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007

Gene names and symbols associated with IDO2

  • indoleamine 2,3-dioxygenase 2 (IDO2)
  • indoleamine 2,3-dioxygenase 2 (Ido2)
  • AI265623 protein
  • C230043N17Rik protein
  • Ido-2 protein
  • Indol1 protein

Protein level used designations for IDO2

indoleamine 2,3-dioxygenase 2 , indoleamine 2,3-dioxygenase 2-like , IDO-2 , indoleamine 2,3-dioxygenase-like 1 protein , indoleamine 2,3-dioxygenase-like protein 1 , indoleamine-pyrrole 2,3 dioxygenase-like 1 , indoleamine-pyrrole 2,3-dioxygenase-like protein 1

GENE ID SPECIES
100402049 Callithrix jacchus
707424 Macaca mulatta
100085939 Ornithorhynchus anatinus
100435160 Pongo abelii
100480334 Ailuropoda melanoleuca
100580956 Nomascus leucogenys
169355 Homo sapiens
482846 Canis lupus familiaris
513810 Bos taurus
681319 Rattus norvegicus
209176 Mus musculus
100056686 Equus caballus
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