Influenza Nucleoprotein Proteins

Encapsidates the negative strand viral RNA, protecting it from nucleases.

Type
  • 2
    Protein
Antigen
  • 2
Reactivity
  • 1
  • 1
Application
  • 1
  • 1
  • 1
  • 1
Host
  • 1
  • 1
Binding Specificity
  • 1
  • 1
Conjugate
  • 2
Protein Type
  • 2
Format
  • 2
2 Products
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 % , based on SDS PAGE
ReactivityCanine Distemper Virus (CDV)
Application Imm, ELISA, WB
Order details Cat. No. ABIN1604800
$218.90
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
Recombinant Protein, Baculovirus infected Insect Cells (Source), Purity > 95 % as determined by SDS-PAGE
ReactivityInfluenza A Virus H2N2
Application SDS
Order details Cat. No. ABIN2006842
Pubmed
ISO
$440.65
Plus shipping costs $45.00
Delivery in 14 to 16 Business Days
  • <
  • 1
  • >

Influenza Nucleoprotein (NP) Protein Profile

Protein Summary

Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).

Gene names and symbols associated with Influenza Nucleoprotein Proteins (NP)

  • nucleoprotein (NP) antibody
GENE ID SPECIES
956539 Influenza B virus
956531 Influenza A virus
Did you look for something else?