Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) ELISA Kits

ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Additionally we are shipping ID4 Antibodies (88) and ID4 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ID4 15904 P41139
ID4 291023  
ID4 3400 P47928
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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
  96 Tests 2 to 3 Days
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  10 reactions 4 to 6 Days

More ELISA Kits for ID4 Interaction Partners

Mouse (Murine) Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states

  2. results indicate that Id4 marks spermatogonial stem cells in the mouse testis.

  3. ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.

  4. Id4 regulates NKX3.1, Sox9 and PTEN.

  5. Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary

  6. High expression levels of Id1-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.

  7. CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell

  8. ID4 promotes mammary gland development by suppressing p38MAPK activity.

  9. Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.

  10. Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.

  11. ID4 has a role in adipocyte differentiation and the implications of this regulation for adipose tissue formation

  12. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa.

  13. Id4 has a unique and complex function in regulating neural stem cell proliferation and differentiation

  14. Id4 has a critical role in regulating neural precursor cell proliferation and differentiation

  15. ID proteins (ID1, ID2, ID3 and ID4) were significantly increased in Mecp2-deficient Rett syndrome brain; ID genes are ideal targets for MeCP2 regulation of neuronal maturation that may explain the molecular pathogenesis of Rett syndrome

  16. these data support the role of Id4 as oligodendrocyte differentiation inhibitor

Zebrafish Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt signaling in the developing AVC endocardium

Human Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) interaction partners

  1. Data propose that ID4 is frequently silenced by promoter methylation in ER+ breast cancers and functions as a tumor suppressor gene in these tumors, probably due to its interaction with key genes of the ER pathway.

  2. At the molecular level, ID4 protein expression in breast cancer cells controls, through paracrine signalling, the activation of an angiogenic programme in macrophages. This programme includes both the increase of angiogenesis-related mRNAs and the decrease of members of the anti-angiogenic miR-15b/107 group.

  3. Low ID4 expression is associated with breast cancer.

  4. These findings indicate that ID4 acts as a tumour suppressor in myeloid malignancies, and ID4 methylation is a potential biomarker in predicting disease progression and treatment outcome.

  5. results highlight a key role for MALAT1 in control of VEGFA isoforms expression in breast cancer cells expressing gain-of-function mutant p53 and ID4 proteins.

  6. Study demonstrates that ID4, can promote p53- dependent apoptosis and senescence in prostate cancer cells by specifically modifying the acetylation of p53, which increases its transcriptional activity and promotes the expression of pro-apoptotic and cell cycle regulatory genes.

  7. The cellular uptake of inhibitor of DNA binding 4 protein (ID4) resulted in increased apoptosis, decreased proliferation and colony formation.

  8. Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.

  9. The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC) patients, and overexpression of Id4 promoted HCC cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.

  10. ID4 selectively regulates AR activity through direct interaction with FKBP52.

  11. High ID4 expression is associated with basal breast cancer.

  12. A cell-autonomous positive-signaling circuit is associated with the PDGFB-NO-ID4-regulatory axis in glioblastoma cells.

  13. ID4 expression induces AR expression in PC3 cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.

  14. CEACAM1 is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 and CaMK2D, and the same kinase enables lumen formation by CEACAM1

  15. In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2)early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1, NR4A2, EGR2, EGR3 and ID4 may be key genes associated with the pathogenesis of DS.

  16. changes in gene amplification in the mitochondrial genome and in the ID4 gene promoter methylation region in patients with chronic aplastic anemia (CAA) suffering from Kidney (Shen) yin deficiency or Kidney yang deficiency, were analyzed.

  17. Hypermethylation of ID4 promotes the proliferation of Burkitt's lymphoma cells; ID4 may function as a tumor suppressor and can be targeted with demethylating compounds such as CdR for the treatment of Burkitt's lymphoma

  18. the unmethylation of ID4 is an epigenetic predictor of BRCAness phenotype in breast tumors.

  19. ID4 hypomethylation is present in tamoxifen-resistant breast cancer, and it may serve as a potential biomarker in distinguishing tamoxifen-resistant breast cancer.

  20. ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 is specifically expressed by a subset of human basal-like breast cancer that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell.

ID4 Antigen Profile

Antigen Summary

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.

Gene names and symbols associated with ID4

  • inhibitor of DNA binding 4 (Id4) antibody
  • inhibitor of DNA binding 4, HLH protein (Id4) antibody
  • inhibitor of DNA binding 4 (id4) antibody
  • inhibitor of DNA binding 4, HLH protein S homeolog (id4.S) antibody
  • inhibitor of DNA binding 4, HLH protein (ID4) antibody
  • bhlhb27 antibody
  • cb547 antibody
  • fb77d04 antibody
  • id4 antibody
  • id4a antibody
  • IDB4 antibody
  • sb:cb547 antibody
  • wu:fb77d04 antibody
  • zgc:123214 antibody

Protein level used designations for ID4

DNA-binding protein inhibitor ID-4 , inhibitor of DNA binding 4 a , class B basic helix-loop-helix protein 27

15904 Mus musculus
291023 Rattus norvegicus
664761 Danio rerio
380396 Xenopus laevis
374150 Gallus gallus
3400 Homo sapiens
610666 Canis lupus familiaris
100144508 Sus scrofa
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