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This locus encodes an inositol monophosphatase. Additionally we are shipping IMPA2 Antibodies (25) and IMPA2 Kits (8) and many more products for this protein.
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IMPA2 has a separate function in vivo from that of IMPA1 (show IMPA1 Proteins)
a correlation between an IMPA2 polymorphism rs589247 and ischemic stroke risk in a northwest Han Chinese
a promoter polymorphism of IMPA2 possibly contributed to risk for schizophrenia by elevating transcription activity in Han Chinese individuals.
results suggest that genetic variability at rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and rs11921360-GSK3b genes is associated with a higher risk of attempting suicide in bipolar patients.
Authors propose that the human myo (show SYNPO2 Proteins)-inositol monophosphatase 2 interacts with myo (show SYNPO2 Proteins)-inositol monophosphates in the three-metal-ion bound form, and proceeds the dephosphorylation through the three-metal-ion theory.
No association is found between IMPA2 gene polymorphisms and bipolar disorder.
The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.
IMPA2 may be a febrile seizure susceptibility gene. 6 SNPs were found: -708G/A, -461C/T, IVS1-15G/A, 159T/C, IVS5+13-14insA, & 558C/T.
the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations.
The crystal structures of human IMPA2 are useful for understanding the effect of nonsynonymous polymorphism reported in IMPA2, and will contribute to further functional analyses of IMPA2.
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder.
inositol(myo)-1(or 4)-monophosphatase 2
, inositol monophosphatase 2
, IMP 2
, IMPase 2
, inositol-1(or 4)-monophosphatase 2
, myo-inositol monophosphatase A2
, inosine monophosphatase 2
, inositol monophosphatase 2 variant 1
, inositol monophosphatase 2 variant 2