Insulin Receptor Substrate 4 (IRS4) ELISA Kits

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Additionally we are shipping IRS4 Antibodies (52) and IRS4 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
IRS4 8471 O14654
IRS4 16370 Q9Z0Y7
Anti-Rat IRS4 IRS4 315350  
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Top IRS4 ELISA Kits at

Showing 2 out of 3 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
  96 Tests 2 to 3 Days
Human < 0.78 ng/mL n/a   96 Tests 15 to 18 Days

More ELISA Kits for IRS4 Interaction Partners

Human Insulin Receptor Substrate 4 (IRS4) interaction partners

  1. IRS4, as a new substrate of CHIP, is negatively regulated by CK1gamma2 at the posttranslational level.

  2. increase of IRS-4 expression may be involved to some extent in colorectal cancer.

  3. IRS4 overexpression is associated with cancer.

  4. these results demonstrated that miR-493 acts as a tumor suppressor and inhibits cell proliferation and cell cycle in human melanoma by directly targeting IRS4.

  5. The association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions.

  6. Overexpression of IRS4 in U2OS cells activates PI3K signalling.

  7. We genotyped single-nucleotide polymorphisms of IGF1, IGF2, IGF1R, IGF2R, IGFBP1, IGFBP3, IGFBP5, IRS1, IRS2, and IRS in pancreatic cancer patients

  8. This study clearly demonstrates associations between body mass index and IRS-4 variants in schizophrenia patients, but not in healthy controls, pointing to a possible involvement of IRS-4 in the control of body weight in schizophrenia.

  9. Study for the first time identified IRS4 mutations in T-ALL.

  10. IRS-4 gene is not of importance for aetiology of the vast majority of schizophrenia cases, but a single patient with schizophrenia and a mutation in IRS-4 points to that the insulin signalling system is of interest in the search for schizophrenia genes

  11. The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.

  12. Insulin receptor substrate 4 associates with the protein IRAS

  13. IRS-4 does not function as a substrate of the insulin and the IGF-I receptor in primary muscle cells but may be involved in nonreceptor tyrosine kinase signaling.

  14. data demonstrate cell-specific alterations in IRS protein concentrations in theca cells from polycystic ovaries consistent with exaggerated amplification of the insulin signal & which may play a role in ovarian hyperandrogenism & thecal hyperplasia

  15. insulin receptor substrate-4 and ShcA have roles in signaling by the fibroblast growth factor receptor

  16. IRS-4 is subject to regulation by TNF-alpha, and PP4 mediates TNF-alpha-induced degradation of IRS-4

  17. endogenous Brk and IRS-4 interact in A431 human epidermoid carcinoma cells

  18. IRS-4 plays an important role in HepG2 proliferation/differentiation and exerts its actions through ERK and p70S6K activation in a ras/raf/MEK1/2- and PI3Kinase/Akt-independent manner and in a PKC-dependent way

  19. Transgenic rat gene WDR6 interacts with insulin receptor substrate 4 (IRS-4) in the rat brain and may participate in signaling and regulation of feeding behavior and longevity in the brain.

  20. 53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates.

Mouse (Murine) Insulin Receptor Substrate 4 (IRS4) interaction partners

  1. our results give the first functional evidence for IRS4 as a critical regulator of BMP/Smad and Akt signalling in the context of muscle differentiation.

  2. conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4

  3. Down-regulation of the insulin receptor substrate 4 (Irs4) gene, may be an important event in the transition from age-related changes to Alzheimer's disease specific-changes.

  4. These data suggest that IRS-dependent signaling pathways work by recruiting different signaling molecules to determine specificity of IL-2R gamma superfamily cytokines.

  5. These data indicate that both insulin receptor substrate (IRS)-1 and -3, but not IRS-2 or IRS-4, play key roles in the differentiation of brown adipocytes.

  6. Data demonstrate that IRS4 interacts with the LR. This recruitment is leptin dependent and requires phosphorylation of the Y1077 motif of the LR.

  7. Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2.

IRS4 Antigen Profile

Antigen Summary

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation..

Gene names and symbols associated with IRS4

  • insulin receptor substrate 4 (IRS4) antibody
  • insulin receptor substrate 4 (irs4) antibody
  • insulin receptor substrate 4 (Irs4) antibody
  • insulin receptor substrate 4 S homeolog (irs4.S) antibody
  • IRS-4 antibody
  • irs2 antibody
  • irs2-a antibody
  • IRS4 antibody
  • PY160 antibody

Protein level used designations for IRS4

insulin receptor substrate 4 , 160 kDa phosphotyrosine protein , phosphoprotein of 160 kDa , pp160 , IRS-2-A , insulin receptor substrate 2-A , insulin receptor substrate protein , insulin receptor substrate-undetermined designation , insulin receptor substrate-unique , xIRS-u

492059 Canis lupus familiaris
514607 Bos taurus
100196925 Xenopus (Silurana) tropicalis
8471 Homo sapiens
16370 Mus musculus
315350 Rattus norvegicus
399388 Xenopus laevis
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