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IGF2R encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor.
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M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by gamma Fc receptors, Grb2, and SHP-1.
IGF2R deletion is associated with motor speech disorders, and language delays.
Heterodimers of the SNX (show ANXA7 Proteins)-BAR proteins, SNX1 (show SNX1 Proteins), SNX2 (show SNX2 Proteins), SNX5 (show SNX5 Proteins), and SNX6 (show SNX6 Proteins), are the cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the trans-Golgi networ independently of the core retromer trimer.
Sequence-dependent cargo recognition by SNX (show ANXA7 Proteins)-BARs mediates retromer-independent transport of CI-MPR.
These data suggest the involvement of IGF-2, IGF-1R, IGF-2R and PTEN in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development.
Findings indicate that IGF2R expression is controlled posttranscriptionally by two factors that associate with Igf2r mRNA and suggest that miR (show MLXIP Proteins)-195 and CUGBP1 (show CELF1 Proteins) dampen IGF signaling by inhibiting IGF2R translation.
Previously characterized disease-causing mutations in IGF2, IGF1R (show IGF1R Proteins), IGF2R, or IGFALS (show IGFALS Proteins) all were found in the general population but with allele frequencies of <1:30,000.
IGF2R plays a minor role in regulating the activity of IGF1R (show IGF1R Proteins) under a variety of conditions and that due to their high expression levels, IGFBPs are the dominant mechanism to regulating IGF network activation
Data show one single nucleotide polymorphism (SNP) in Fox transcription factor FOXO3 (FOXO3 (show FOXO3 Proteins)) was significantly associated with longevity, and the six SNPs in proto-oncogene (show RAB1A Proteins) protein AKT1 (AKT1 (show AKT1 Proteins)) gene and in IGF-2 Receptor (IGF-2R) gene are not.
CREB (show CREB1 Proteins) plays an important role in the inhibition of IGF2R expression by binding to the IGF2R promoter and further suppresses H9c2 cardiomyoblast cell apoptosis induced by IGF2R signaling under hypoxic conditions.
After 6 weeks of environmental tobacco smoke exposure, the Sirt-1 (show SIRT1 Proteins) protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced.
Selective M6PR (show M6PR Proteins) down-regulation has a critical role in CD8 (show CD8A Proteins)(+) T cell survival.
Expression of imprinted gene Igf2r was unregulated in haploid androgenetic/gynogenetic blastocysts.
that an elevation in IGF-II receptor levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.
DNA methylation (show HELLS Proteins) changes were noted in the Igf2r gene during chronic cystitis in a murine model.
Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation.
The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin.
mannose 6-phosphate/IGF2R knock-down in receptor-positive mouse hepatocytes causes increased cathepsin secretion as well as enhanced cell motility and invasiveness
enhanced CI-MPR expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA (show GAA Proteins).
The interaction of sM6P/IGF2R with Plg (show PLG Proteins) may be an important regulatory mechanism to inhibit migration of cells using the uPA (show PLAU Proteins)/uPAR (show PLAUR Proteins) system.
study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles
imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy
Increases in CYP19A1 (show CYP19A1 Proteins) and FSHR (show FSHR Proteins) mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 (show IGF1 Proteins) production.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation (show HELLS Proteins) patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Expression and binding properties of mannose-6-phosphate receptors CD-MPR (show M6PR Proteins) and CI-MPR differ during perinatal development in rat liver.
the interaction between uPAR (show PLAUR Proteins) and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR (show PLAUR Proteins) bind the Man-6-P/IGF2R by different mechanisms.
Results describe the crystal structure of the N-terminal 432 residues of the cation-independent mannose 6-phosphate receptor, which encompass three out of the 15 repetitive domains of its extracytoplasmic region.
CI-MPR contains a third Man-6-P recognition site that is located in domain 5 and that exhibits lower affinity than the carbohydrate-binding sites present in domains 1-3 and 9
IGF2R is expressed from both parental alleles although differential allelic expression may occur.
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
300 kDa mannose 6-phosphate receptor
, CI Man-6-P receptor
, IGF-II receptor
, M6P/IGF2 receptor
, MPR 300
, cation-independent mannose-6 phosphate receptor
, cation-independent mannose-6-phosphate receptor
, insulin-like growth factor II receptor
, cation-independent MPR
, cation-independent mannose 6-phosphate receptor
, mannose-6-phosphate receptor, cation independent
, insulin-like growth factor receptor type 2
, cation-independent mannose 6 phosphate receptor
, insulin-like growth factor 2 receptor