anti-Integrin beta 1 Binding Protein (Melusin) 2 (ITGB1BP2) Antibodies

Human Integrin beta 1 Binding Protein (Melusin) 2 (ITGB1BP2) interaction partners

1. Studies in mouse show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.

2. Chp-1 (show CHP Antibodies) and melusin can interact with cochaperones PP5 (show PPP5C Antibodies) and Sgt1 (show SUGT1 Antibodies) and with each other in an ATP-dependent manner

3. Identification of a missense mutation in the melusin-encoding ITGB1BP2 gene in a patient with dilated cardiomyopathy

4. The altered melusin pathways and CDC42 (show CDC42 Antibodies) parallel the cardiac function progression during cardiac remodeling post-MI.

5. Our analysis revealed an extremely low number of variations in the ITGB1BP2 gene in nearly 1000 hypertensive/cardiopathic and healthy individuals, thus suggesting a high degree of conservation of the melusin gene within the populations analyzed

Mouse (Murine) Integrin beta 1 Binding Protein (Melusin) 2 (ITGB1BP2) interaction partners

1. Findings implicate melusin as an enhancer of AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) pathways and as a novel player in cardioprotection from ischemia-reperfusion injury.

2. Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy.

3. Chp-1 (show CHORDC1 Antibodies) and melusin can interact with cochaperones PP5 (show PPP5C Antibodies) and Sgt1 (show SUGT1 Antibodies) and with each other in an ATP-dependent manner

4. controls ERK1/2 activation in heart

5. PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment

6. Data show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.

7. Melusin directly binds to Hsp90 (show HSP90 Antibodies), a ubiquitous chaperone involved in regulating several signaling pathways.