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May play a role during maturation and/or organization of muscles cells (By similarity). Additionally we are shipping Integrin beta 1 Binding Protein (Melusin) 2 Proteins (6) and Integrin beta 1 Binding Protein (Melusin) 2 Kits (5) and many more products for this protein.
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Cow (Bovine) Polyclonal ITGB1BP2 Primary Antibody for IHC, WB - ABIN2775372
Madigan, Ladd, Goldberg: A picture is worth a thousand words: children's representations of family as indicators of early attachment. in Attachment & human development 2003
Show all 2 Pubmed References
Studies in mouse show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.
Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
Identification of a missense mutation in the melusin-encoding ITGB1BP2 gene in a patient with dilated cardiomyopathy
The altered melusin pathways and CDC42 parallel the cardiac function progression during cardiac remodeling post-MI.
Our analysis revealed an extremely low number of variations in the ITGB1BP2 gene in nearly 1000 hypertensive/cardiopathic and healthy individuals, thus suggesting a high degree of conservation of the melusin gene within the populations analyzed
Findings implicate melusin as an enhancer of AKT and ERK pathways and as a novel player in cardioprotection from ischemia-reperfusion injury.
reduces maladaptive remodelling after myocardial infarction
Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy.
controls ERK1/2 activation in heart
PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment
Data show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress.
Melusin directly binds to Hsp90, a ubiquitous chaperone involved in regulating several signaling pathways.
May play a role during maturation and/or organization of muscles cells (By similarity).
integrin beta-1-binding protein 2