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The protein encoded by ILKAP is a protein serine/threonine phosphatase of the PP2C family. Additionally we are shipping Integrin-Linked Kinase-Associated Serine/threonine Phosphatase 2C Antibodies (90) and Integrin-Linked Kinase-Associated Serine/threonine Phosphatase 2C Proteins (9) and many more products for this protein.
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ILKAP physically interacted with HIF-1A and induced its dephosphorylation. Both the HIF-1A-p53 interaction and apoptosis relied on ILKAP.
our data suggest an essential role of PINCH1, ILK and ILKAP for the radioresistance of p53-wildtype glioblastoma multiforme cells
The expression of ILKAP was considerably lower in eutopic and ectopic endometrial samples from women with endometriosis than in control endometrium. Expression varied depending on the phase of the menstrual cycle.
Data show involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma
ILKAP is a nuclear protein that regulates cell survival and apoptosis through the regulation of RSK2 signaling.
these results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis.
These studies demonstrate the importance for keratinocyte proliferation of ILK regulation through changes in its subcellular localization, and establish ILKAP and CRM1 as pivotal modulators of ILK subcellular distribution and activity in these cells.
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
integrin-linked kinase-associated serine/threonine phosphatase 2C
, integrin-linked kinase-associated protein phosphatase 2C
, integrin-linked kinase-associated serine/threonine phosphatase 2C-like
, integrin-linked kinase-associated serine/threonine phosphatase
, integrin-linked kinase associated phosphatase
, protein phosphatase 2c, delta isozyme
, protein phosphatase 2C