Interferon, alpha-Inducible Protein 6 Proteins (IFI6)

IFI6 was first identified as one of the many genes induced by interferon. Additionally we are shipping IFI6 Antibodies (51) and IFI6 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IFI6 2537 P09912
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Top IFI6 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
Yeast Human His tag 100 μg 8 to 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

IFI6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Interferon, alpha-Inducible Protein 6 (IFI6) Interaction Partners

Human Interferon, alpha-Inducible Protein 6 (IFI6) interaction partners

  1. Consequent to its localisation on inner-mitochondrial membrane, mtROS were higher in G1P3-expressing cells (MCF-7G1P3). This study identified that G1P3-induced mtROS have a direct role in migratory structure formation and nuclear gene expression to promote breast cancer cell metastasis.

  2. Flavivirus replication at the ER is targeted by the interferon (IFN) response. Interferon alpha inducible protein 6 (IFI6) is an endoplasmic reticulum (ER)-localized integral membrane effector that is stabilized through interactions with the ER-resident heat shock protein 70 chaperone BiP. IFI6 prophylactically protects uninfected cells by preventing the formation of virus-induced ER membrane invaginations.

  3. Data suggest that p7 is a critical immune evasion protein that suppresses the antiviral interferon function by counteracting the function of IFI6-16.

  4. In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1, TLR3, OAS1, EIF2AK2, HLA-E, IFI6, and STAT1, showed higher expression in the islet core compared with the peri-islet area containing the surrounding immune cells

  5. In conclusion, over-expression of IFI6 promotes hepatitis C virus RNA replication and rescues the interferon alpha-mediated anti-hepatitis C virus activity.

  6. IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions. This may be relevant to other virus entry processes employing EGFR.

  7. Here we elucidate G1P3, a survival protein induced by interferons (IFNs), as a target of estrogen signaling and a contributor to poor outcomes in estrogen receptor-positive (ER(+)) breast cancer.

  8. PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations.

  9. G1P3 protein may have function as a cell survival protein by inhibiting mitochondrial-mediated apoptosis

  10. Respiratory syncytial virus upregulated the mRNA expression of chemokines CC and CXC and interfered with type alpha/beta interferon-inducible gene expression by upregulation of MG11 and downregulation of G1P3.

  11. IFN-alpha2b induced the expression of G1P3 and antagonized the TRAIL induced apoptosis in myeloma suggesting that either the deregulated or the induced expression of G1P3 could lead to apoptosis resistance in tumor cells.

IFI6 Protein Profile

Protein Summary

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.

Gene names and symbols associated with IFI6

  • interferon, alpha-inducible protein 6 (IFI6)
  • interferon alpha inducible protein 6 (IFI6)
  • 6-16 protein
  • FAM14C protein
  • G1P3 protein
  • Ifi-6-16 protein
  • IFI616 protein

Protein level used designations for IFI6

interferon alpha-inducible protein 6 , interferon, alpha-inducible protein clone IFI-6-16 , interferon-induced protein 6-16 , ifi-6-16

100190421 Taeniopygia guttata
2537 Homo sapiens
512913 Bos taurus
450178 Pan troglodytes
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