Interferon Induced Transmembrane Protein 2 Proteins (IFITM2)

IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Additionally we are shipping IFITM2 Antibodies (48) and IFITM2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IFITM2 10581 Q01629
IFITM2 80876 Q99J93
Rat IFITM2 IFITM2 114709  
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Top IFITM2 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Human His-GST 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg 6 to 9 Days
$356.74
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details

IFITM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Interferon Induced Transmembrane Protein 2 (IFITM2) Interaction Partners

Human Interferon Induced Transmembrane Protein 2 (IFITM2) interaction partners

  1. overexpression of IFITM1, 2 and 3 suppressed entry of CXCR4 and CCR5 tropic viruses; entry of transmitted founder HIV-1 in U87 cells is more sensitive to inhibition by IFITM2 and IFITM3 than by IFITM1

  2. Delta20 IFITM2 may serve as a major contributor to the gatekeeping mechanism that explains restriction of X4 viruses in the early stage of HIV-1 infection

  3. These results indicate that IFITM2 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.

  4. The transcriptional regulation of IFITM1, 2 and 3 expression.

  5. IFITM2 promotes gastric cancer growth and metastasis via IGF1/IGF1R/STAT3 signaling pathway.

  6. findings show that the sensitivity of influenza A viruses to the IFN-induced antiviral state and IFITM2 and IFITM3 proteins depends on the pH value at which the viral HA undergoes a conformational transition and mediates membrane fusion

  7. IFITM2 and IFITM3 specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection.

  8. propose that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific

  9. G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.

  10. In virus-producing cells, IFITMs coalesce with forming virions and are incorporated into HIV-1 viral particles.

  11. Incorporation of IFITM1, IFITM2 and IFITM3 into HIV-1 virions impair viral fusion and spread.

  12. Host IFITM3,IFITM2 and IFITM1 facilitate morphogenesis of the human cytomegalovirus assembly.

  13. Although their inhibitory activities were modest when compared to that of tetherin, IFITMs, but not tetherin, directly reduced the expression of HIV-1 proteins including Gag, Vif and Nef.

  14. Authors show that interferon-induced transmembrane protein 1 (IFITM-1), IFITM-2, and IFITM-3 exhibit a broad spectrum of antiviral activity against several members of the Bunyaviridae family.

  15. IFITM1, IFITM2, and IFITM3 inhibit HIV-1 replication through interfering with virus entry.

  16. IFITM2 and IFITM3, disrupted early steps (entry and/or uncoating) of the viral infection, viperin, ISG20, and double-stranded-RNA-activated protein kinase, inhibited steps in west nile virus and dengue virus viral proteins and/or RNA biosynthesis.

  17. Single Nucleotide Polymorphisms in 1-8D is associated with neoplasms.

Mouse (Murine) Interferon Induced Transmembrane Protein 2 (IFITM2) interaction partners

  1. this study shows that IFITM2 drives type 2 T helper cell differentiation and exacerbate allergic airway inflammation

IFITM2 Protein Profile

Protein Summary

IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.

Gene names and symbols associated with IFITM2

  • interferon induced transmembrane protein 2 (IFITM2)
  • interferon induced transmembrane protein 2 (Ifitm2)
  • 1-8D protein
  • DSPA2c protein
  • fragilis3 protein
  • Ifitm3l protein
  • Ifitml protein
  • mil-3 protein

Protein level used designations for IFITM2

dispanin subfamily A member 2c , interferon-induced transmembrane protein 2 , interferon-inducible protein 1-8D , fragilis R , fragilis protein 3 , interferon induced transmembrane protein, like , interferon induced transmembrane protein 2 (1-8D) , interferon-inducible protein 16

GENE ID SPECIES
10581 Homo sapiens
80876 Mus musculus
114709 Rattus norvegicus
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