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IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Additionally we are shipping IFITM2 Antibodies (47) and IFITM2 Kits (3) and many more products for this protein.
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Delta20 IFITM2 may serve as a major contributor to the gatekeeping mechanism that explains restriction of X4 viruses in the early stage of HIV-1 infection
These results indicate that IFITM2 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.
The transcriptional regulation of IFITM1 (show IFITM1 Proteins), 2 and 3 expression.
IFITM2 promotes gastric cancer growth and metastasis via IGF1 (show IGF1 Proteins)/IGF1R (show IGF1R Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.
findings show that the sensitivity of influenza A viruses to the IFN-induced antiviral state and IFITM2 and IFITM3 (show IFITM3 Proteins) proteins depends on the pH value at which the viral HA undergoes a conformational transition and mediates membrane fusion
IFITM2 and IFITM3 (show IFITM3 Proteins) specifically antagonize the HIV-1 envelope glycoprotein (Env (show ERVW-1 Proteins)), thereby inhibiting viral infection.
G3BP1 (show G3BP1 Proteins), G3BP2 (show G3BP2 Proteins) and CAPRIN1 are required for translation of interferon (show IFNA Proteins) stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
Incorporation of IFITM1 (show IFITM1 Proteins), IFITM2 and IFITM3 (show IFITM3 Proteins) into HIV-1 virions impair viral fusion and spread.
Host IFITM3 (show IFITM3 Proteins),IFITM2 and IFITM1 (show IFITM1 Proteins) facilitate morphogenesis of the human cytomegalovirus assembly.
Although their inhibitory activities were modest when compared to that of tetherin (show BST2 Proteins), IFITMs, but not tetherin (show BST2 Proteins), directly reduced the expression of HIV-1 proteins including Gag, Vif (show BTG1 Proteins) and Nef.
IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.
dispanin subfamily A member 2c
, interferon-induced transmembrane protein 2
, interferon-inducible protein 1-8D
, fragilis R
, fragilis protein 3
, interferon induced transmembrane protein, like
, interferon induced transmembrane protein 2 (1-8D)
, interferon-inducible protein 16