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Acts as a transcriptional corepressor in a IRF2- dependent manner\; this repression is not mediated by histone deacetylase activities. Additionally we are shipping IRF2BP1 Antibodies (54) and IRF2BP1 Kits (4) and many more products for this protein.
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Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 (show IRF2BP2 Proteins) as co-repressor molecules for interferon regulatory factor-2 (show IRF2 Proteins).
PCTA (IRF2BP1) defines a new component of the TGF-beta (show TGFB1 Proteins) signalling pathway that functions to facilitate Smad2 (show SMAD2 Proteins) phosphorylation through controlling the accumulation of cPML into the cytoplasm, and consequently, the assembly of Smad2 (show SMAD2 Proteins)-receptor complex.
IRF2 (show IRF2 Proteins)-BP1 (show DLX4 Proteins) is a JDP2 (show JDP2 Proteins)-binding protein enhancing the polyubiquitination of JDP2 (show JDP2 Proteins) and represses ATF2 (show ATF2 Proteins)-mediated transcriptional activation from a CRE-containing promoter.
Acts as a transcriptional corepressor in a IRF2- dependent manner\; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
IRF-2-binding protein 1
, interferon regulatory factor 2-binding protein 1
, probable E3 ubiquitin-protein ligase IRF2BP1
, interferon regulatory factor 2-binding protein 1-like
, IRF2 binding protein 1