anti-Interferon Related Developmental Regulator 1 (IFRD1) Antibodies

Human Interferon Related Developmental Regulator 1 (IFRD1) interaction partners

1. Results from a study on gene expression variability markers in early-stage human embryos shows that IFRD1 is a putative marker for the 3-day, 8-cell embryo stage.

2. High IFRD1 colon cancer expression was significantly associated with decreased 5-year patient survival.

3. this study shows that IFRD1 gene may be associated with pathogenesis of asthma

4. rs7817 polymorphism associated with nasal polyposis in cystic fibrosis patients

5. study reveals an EGFR-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells

6. rs5009270 may contribute to hip OA susceptibility by altering proximal femur shape.

7. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta.

8. Studied the association between IFRD1 polymorphisms and gastric cancer in a Chinese population.

9. IFRD1 expression is systemically up-regulated in CF neutrophils, is linked to the production of ROS, and is modulated by chemokines in CF airway fluids, depending on the IFRD1 genotype.

10. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models.

11. IFRD1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.

12. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in rat as nerve growth factor-inducible immediate early gene (named PC4).

13. IFRD1 is an inducer of skeletal muscle regeneration and of satellite cell amplification, by regulating MyoD and NF-kB.

14. Identification of PC4/IFRD1 as a coactivator of MyoD, a key master gene of muscle development.

15. In the absence of PC4/IFRD1 skeletal muscle differentiation is defective.

16. IFRD1 mRNA decay stress-sensitive regulation is mediated by an upstream open reading frame

17. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes

18. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity

19. Sequence conservation, animal models, and protein structure evaluation support the involvement of IFRD1 in SMNA

20. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7).

Mouse (Murine) Interferon Related Developmental Regulator 1 (IFRD1) interaction partners

1. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.

2. adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.

3. These results suggest that BMP-2 directly induces Ifrd1 expression at the transcriptional level in osteoblasts via the Smad pathway, and Ifrd1 negatively regulates BMP-2-dependent osteoblastogenesis.

4. Ifrd1 has a pivotal role in bone homeostasis through its expression in osteoblasts in vivo and represents a therapeutic target for bone diseases.

5. High-fat diet feeding in the setting of tis7 deletion resulted in postresection anastomotic inflammation and small bowel obstruction.

6. TIS7 predominantly interacted with beta-catenin in the nucleus.

7. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models.

8. PC4 plays a role in muscle differentiation by controlling the MyoD pathway through multiple mechanisms, and as such, it positively regulates regenerative myogenesis.

9. altered postresection adaptive responses of Tis7 knockout mice in short bowel syndrome model; results suggest a novel physiologic function for Tis7 in gut as global regulator of lipid absorption/metabolism and epithelial cell proliferation

10. TIS7 protein interacts with several proteins of the SIN3 complex (mSin3B, HDAC1, N-CoR and SAP30. TIS7 is a transcriptional co-repressor affecting expression of specific genes in a HDAC-activity-dependent manner during cell fate decisions.

11. Its expression may be involved in differentiation of neuronal progenitor cells to spiral ganglion cells by the initial sound input.

12. Results suggest that TIS7 is not essential for mouse development but plays a novel regulatory role during adult muscle regeneration.

13. TIS7 is a unique mediator of nutrient absorptive and metabolic adaptation following gut resection

14. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes

15. TIS7 inhibits CRABP II expression during axonal regeneration, thereby modulating retinoic acid signalling. Hence, neurite initiation and branching are regulated by a negative feedback mechanism involving TIS7 and CRABP II.

16. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity

17. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7).

18. The gene IFRD1/PC4 is required for muscle differentiation. Inhibition of PC4 expression in myoblasts prevents morphological differentiation, impairing myogenin and myosin gene expression. This finding has been confirmed by gene knockout in mice.