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findings reveal that oridonin protects against OVX-induced bone loss via inhibiting osteoclastic bone resorption but enhancing osteoblastic bone formation through abolishing both Ifrd1-mediating and IkappaBalpha-mediated p65 nuclear translocation.
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Ifrd1 is a critical mediator of both osteoblastogenesis and osteoclastogenesis through its expression in osteoblasts.
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Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.
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adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
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These results suggest that BMP-2 directly induces Ifrd1 expression at the transcriptional level in osteoblasts via the Smad pathway, and Ifrd1 negatively regulates BMP-2-dependent osteoblastogenesis.
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Ifrd1 has a pivotal role in bone homeostasis through its expression in osteoblasts in vivo and represents a therapeutic target for bone diseases.
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High-fat diet feeding in the setting of tis7 deletion resulted in postresection anastomotic inflammation and small bowel obstruction.
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TIS7 predominantly interacted with beta-catenin in the nucleus.
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This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models.
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PC4 plays a role in muscle differentiation by controlling the MyoD pathway through multiple mechanisms, and as such, it positively regulates regenerative myogenesis.
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altered postresection adaptive responses of Tis7 knockout mice in short bowel syndrome model; results suggest a novel physiologic function for Tis7 in gut as global regulator of lipid absorption/metabolism and epithelial cell proliferation
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TIS7 protein interacts with several proteins of the SIN3 complex (mSin3B, HDAC1, N-CoR and SAP30. TIS7 is a transcriptional co-repressor affecting expression of specific genes in a HDAC-activity-dependent manner during cell fate decisions.
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Its expression may be involved in differentiation of neuronal progenitor cells to spiral ganglion cells by the initial sound input.
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Results suggest that TIS7 is not essential for mouse development but plays a novel regulatory role during adult muscle regeneration.
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TIS7 is a unique mediator of nutrient absorptive and metabolic adaptation following gut resection
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TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes
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TIS7 inhibits CRABP II expression during axonal regeneration, thereby modulating retinoic acid signalling. Hence, neurite initiation and branching are regulated by a negative feedback mechanism involving TIS7 and CRABP II.
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identification of IFRD1 as a modifier of cystic fibrosis lung disease severity
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This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7).
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The gene IFRD1/PC4 is required for muscle differentiation. Inhibition of PC4 expression in myoblasts prevents morphological differentiation, impairing myogenin and myosin gene expression. This finding has been confirmed by gene knockout in mice.