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The protein encoded by IFITM3 is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Additionally we are shipping Interferon-Induced Transmembrane Protein 3 Antibodies (50) and Interferon-Induced Transmembrane Protein 3 Kits (10) and many more products for this protein.
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Human IFITM3 Protein expressed in Wheat germ - ABIN1307445
Yao, Dong, Zhu, Nelson, Liu, Lambiase, Li: Identification of the IFITM3 gene as an inhibitor of hepatitis C viral translation in a stable STAT1 cell line. in Journal of viral hepatitis 2011
IFITM1 (show IFITM1 Proteins) and IFITM3 inhibit Zika virus infection early in the viral life cycle.
ZMPSTE24 (show Zmpste24 Proteins) is a downstream effector of IFITM3 and is important for interferon (show IFNA Proteins)-induced transmembrane antiviral activity.
IFITM3 represents a checkpoint regulator of antiviral immunity that controls cytokine production to restrict viral pathogenesis.
Collectively, the data define an antiviral role for Ifitm3 in restricting infection of multiple alphaviruses.
Ifitm3 plays a role in mouse primordial germ cell homing and repulsion by enhancing the regionalization of PGCs.
Ifitm3 does not impact on the restriction or pathogenesis of bacterial (Salmonella typhimurium, Citrobacter rodentium, Mycobacterium tuberculosis) or protozoan (Plasmodium berghei) pathogens, despite in vitro evidence.
results suggest that modification of Tyr (show TYR Proteins)(20) may serve in a cellular checkpoint controlling IFITM3 trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3
Interferon-induced transmembrane protein 3 is a type II transmembrane protein (show SLC3A2 Proteins).
results revealed diverse, yet consistent, profiles of IFITM3 localization throughout the gastrula
Induction of IFITM3 expression in astrocytes leads to brain dysfunction by impairing neurite development and other non-cell autonomous effects such as increasing mRNA levels of inflammatory cytokines.
IFITM3 is upregulated in patient-derivedbrain tumor-propagating cells (BTPCs) upon irradiation but does not affect brain tumor formation or progression in vivo.
These results indicate that IFITM3 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.
The transcriptional regulation of IFITM1 (show IFITM1 Proteins), 2 and 3 expression.
We failed to confirm an association between the rs12252_C allele of IFITM3 and influenza susceptibility in 2 cohorts of children.
homozygous IFITM3 CC and TLR3 (show TLR3 Proteins) CC genotypes showed significant independent associations with higher death risks in H7N9/H1N1pdm09 influenza in a large Chinese cohort
We found evidence of a new association of rs34481144 with severe influenza in three cohorts characterized by different levels of influenza illness severity. rs34481144 is an expression quantitative trait locus (eQTL (show EQTN Proteins)) for IFITM3, with the risk allele associated with lower mRNA expression. The risk allele was found to have decreased IRF3 (show IRF3 Proteins) binding and increased CTCF (show CTCF Proteins) binding in promoter-binding assays.
IFITM3 rs12252 variant was associated with respiratory infection hospitalization but not specifically in patients infected with Influenza A(H1N1)pdm09.
findings show that the sensitivity of influenza A viruses to the IFN-induced antiviral state and IFITM2 (show IFITM2 Proteins) and IFITM3 proteins depends on the pH value at which the viral HA undergoes a conformational transition and mediates membrane fusion
The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined.
Interferon-induced transmembrane protein 3
, dispanin subfamily A member 2b
, fragilis protein
, ifitm-like protein 1
, interferon-induced transmembrane protein 3
, interferon-inducible protein 15
, interferon-inducible protein 1-8U
, interferon-inducible protein variant 10