IFITM3 Protein (Fc Tag)

Catalog No. ABIN7196277

Product Details

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IFITM3 protein is labelled with Fc Tag.

Purpose: Recombinant Human IFITM3 Protein (Fc Tag)

Sequence: Met 1-His57

Characteristics: A DNA sequence encoding the human IFITM3 (NP_066362.2) (Met1-His57) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.

Purity: > 99 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Alternative Name: IFITM3 (IFITM3 Products)

Synonyms: 1110004C05Rik Protein, Cd225 Protein, Cdw217 Protein, DSPA2b Protein, Fgls Protein, IP15 Protein, mil-1 Protein, 1-8U Protein, rat8 Protein, Interferon-induced transmembrane protein 3 Protein, interferon induced transmembrane protein 3 Protein, ifm3 Protein, Ifitm3 Protein, IFITM3 Protein

Background:

Background: Interferon-induced transmembrane protein 3 (IFITM3) belongs to the CD225 family. To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible transmembrane protein family members, IFITM1, 2 and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. IFITM3 is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. It is both necessary and sufficient for preventing the emergence of viral genomes from the endosomal pathway. Viral pseudoparticles were inhibited from transferring their contents into the host cell cytosol by IFN, and IFITM3 was required and sufficient for this action. IFITM3 overexpression is sufficient for this phenotype. Moreover, IFITM3 partially resides in late endosomal and lysosomal structures, placing it in the path of invading viruses.

Synonym: 1-8U,DSPA2b,IP15

Molecular Weight: 32.9 kDa

NCBI Accession: NP_066362