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May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function.
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Human IL26 ELISA Kit for Sandwich ELISA - ABIN414795
Esendagli, Kurne, Sayat, Kilic, Guc, Karabudak: Evaluation of Th17-related cytokines and receptors in multiple sclerosis patients under interferon ?-1 therapy. in Journal of neuroimmunology 2013
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Human IL26 ELISA Kit for Sandwich ELISA - ABIN365234
Guerra-Laso, Raposo-García, García-García, Diez-Tascón, Rivero-Lezcano: Microarray analysis of Mycobacterium tuberculosis-infected monocytes reveals IL26 as a new candidate gene for tuberculosis susceptibility. in Immunology 2015
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The varIL26 genotype is associated with reduced PMN (show TBCE ELISA Kits) capacity to kill bacteria. A varIL26 genotype is associated with decreased levels of anti-TNF-alpha (show TNF ELISA Kits) in CD patients. IL26 may help explain the role of bactDNA as a risk factor of flare in CD patients.
IL-26 activates STAT1 (show STAT1 ELISA Kits)/3 and leads to the induction of IL-6 (show IL6 ELISA Kits) and IL-8 (show IL8 ELISA Kits) expression in non-transformed cells derived from human colon.
IL-26 levels are higher in synovial fluid compared to plasma in spondyloarthritis. IL-26 was identified in axial facet joints of spondyloarthritis patients. Myofibroblasts from the spondyloarthritis synovium produce large amounts of IL-26. IL-26 induces bone mineralization in human osteoblasts.
this study shows that IL-26 is a unique cationic protein more similar to a soluble pattern recognition receptor than to conventional cytokines
this study shows that single nucleotide polymorphism near IL-26 gene is associated with familial vitiligo (show MITF ELISA Kits) and existence of halo nevi in Estonian patients
Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation.
IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans. [Review]
The negative influence of IL-26 on the anti-mycobacterial activity and its constitutive presence in both serum and monocyte supernatants prompt a proposal that IL26 as a candidate gene for tuberculosis susceptibility.
IL-26 differentially modulates the infection by different enveloped viruses.
Elevated levels of IL-26 in human gastric cancer promote proliferation and survival by modulating STAT1 (show STAT1 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) signaling.
Expression analysis of IL-22 (show IL22 ELISA Kits), IL-26 and two IFN-gamma (show IFNG ELISA Kits) genes suggests an active role of these genes in immune responses in fish.
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
, interleukin 26