anti-Interleukin 27 (IL27) Antibodies

Human Interleukin 27 (IL27) interaction partners

1. IL-27 may be involved in the development of coronary artery lesions in acute Kawasaki disease.

2. Hepatitis B virus infection can lead to overexpression of interleukin-27 gene in liver transplant patients.

3. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

4. IL-27 signaling (IL-27 and its receptor) may be involved in the pathogenesis of HIV infection and immune reconstitution in HIV/AIDS patients who underwent HAART. IL-27 may exert effects through regulating Th1 (show TH1L Antibodies) / Th2 ratio.

5. This study provides additional evidence that IL-27 may contribute to autoimmune processes in MS patients.

6. this study shows that IL-27 regulates the adherence, proliferation, and migration of placenta-derived mesenchymal stromal cells and enhances their regulatory effects on Th1 (show TH1L Antibodies) and Th2 subset generations

7. This study failed to find an association between common variants in the functional region of IL27 and coronary artery disease in a Chinese Han population

8. Data point out to a broad set of activities shared by IL-27 and IFN-gamma (show IFNG Antibodies), which are dependent on the common activation of the STAT1 (show STAT1 Antibodies) pathway. These data add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation

9. The current meta-analysis suggests that IL-27 -964A/G polymorphism might enhance cancer risk. However, large-scale and well-designed studies are still needed to confirm the result of our meta-analysis

10. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1 (show IL27RA Antibodies)) on fetal membranes in cases of preterm birth

Mouse (Murine) Interleukin 27 (IL27) interaction partners

1. IFN-gamma (show IFNG Antibodies) induces IL-30 production which suppresses IFN-gamma (show IFNG Antibodies) mediated liver inflammation.

2. IL-27 signaling in Foxp3 (show FOXP3 Antibodies)(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system

3. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

4. this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4 (show CD4 Antibodies)(+) single positive thymocytes.

5. TTP (show ZFP36 Antibodies), encoded by Zfp36 (show ZFP36 Antibodies), degrades p28 (show GSTO1 Antibodies) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

6. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (show TXNRD1 Antibodies)-like cells in celiac disease

7. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (show TP53 Antibodies) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.

8. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (show LTF Antibodies).

9. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (show TLR4 Antibodies) injection compared with control specimens.

10. these findings highlight critical roles for IFN-gamma (show IFNG Antibodies) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation

Pig (Porcine) Interleukin 27 (IL27) interaction partners

1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).