anti-Interleukin 27 (IL27) Antibodies

Human Interleukin 27 (IL27) interaction partners

1. our results showed that SNP rs153109 displayed significant associations with dilated cardiomyopathy in Chinese Han population, whereas no differences in genotype or allele frequencies were found between dilated cardiomyopathy patients and controls at SNP rs17855750.

2. Human Immunodeficiency virus type-1 myeloid derived suppressor cells inhibit cytomegalovirus inflammation through IL-27 and B7-H4 (show VTCN1 Antibodies).

3. IL-27 enhances the potential of reactive oxygen species generation from monocyte-derived macrophages and dendritic cells by induction of p47(phox).

4. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review)

5. IL-27 rs153109 and rs17855750 Polymorphisms are associated with Risk and Response to Therapy in Acute Lymphoblastic Leukemia.

6. IL-27 was down-regulated in the malignant Middle Cerebral Artery Infarction.

7. IL-27 may be involved in the development of coronary artery lesions in acute Kawasaki disease.

8. Hepatitis B virus infection can lead to overexpression of interleukin-27 gene in liver transplant patients.

9. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

10. IL-27 signaling (IL-27 and its receptor) may be involved in the pathogenesis of HIV infection and immune reconstitution in HIV/AIDS patients who underwent HAART. IL-27 may exert effects through regulating Th1 (show TH1L Antibodies) / Th2 ratio.

Mouse (Murine) Interleukin 27 (IL27) interaction partners

1. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review)

2. Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4 (show TLR4 Antibodies)-dependent manner, likely via downregulating LXR (show NR1H3 Antibodies) expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses.

3. IFN-gamma (show IFNG Antibodies) induces IL-30 production which suppresses IFN-gamma (show IFNG Antibodies) mediated liver inflammation.

4. IL-27 signaling in Foxp3 (show FOXP3 Antibodies)(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system

5. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

6. this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4 (show CD4 Antibodies)(+) single positive thymocytes.

7. TTP (show ZFP36 Antibodies), encoded by Zfp36 (show ZFP36 Antibodies), degrades p28 (show GSTO1 Antibodies) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

8. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (show TXNRD1 Antibodies)-like cells in celiac disease

9. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (show TP53 Antibodies) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.

10. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (show LTF Antibodies).

Pig (Porcine) Interleukin 27 (IL27) interaction partners

1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).