anti-Interleukin 27 (IL27) Antibodies

Human Interleukin 27 (IL27) interaction partners

1. A role for IL-27 in modulating innate immune responses to bacterial infection.

2. The IL-27 promoted the regulatory effects of Human mesenchymal stromal cells (hPMSCs) by enhancing the generation of CD4(+)IL-10(+)IFN-gamma(+) T cells from activated PBMC.

3. IL-27 appears to have a dual role in GBS, with initial pro-inflammatory effects, followed by anti-inflammatory properties during recovery.

4. IL-27 is part of the antiviral response by uterine cells against potential pathogens; effect of estradiol on IL-27 production and sensitivity by fibroblasts demonstrates a selective hormone action on individual cell types in the uterus and suggests that IL-27 may have differential effects during the menstrual cycle

5. This work represents an advance in biomedical science because it excludes the rs153109 A/G (IL-27) SNP, but points to the value of the rs1929992 A/G (IL-33) SNP, in determining susceptibility to breast cancer, so that the latter SNP may be used as a marker to identify individuals at high risk for this disease.

6. Study found no statistically significant difference between the studied groups regarding the IL-27p28 genotypes and revealed that TNF-alpha rs1800629 polymorphism is a potential genetic-susceptibility factor for hepatitis C virus related cirrhosis and hepatocellular carcinoma progression in Egyptian patients.

7. In vitro IL-8 production by IL-27 and IL-37 pre-treated neutrophils and monocytes was significantly inhibited.

8. A total of 885 septic patients and 1101 healthy controls were enrolled and genotyped for IL-27 genetic variants (rs153109/-964A > G and rs17855750/2905 T > G). Quantitative real-time PCR and enzyme-linked immunosorbent assays were performed to detect IL-27 expression and cytokine production. The effect of the rs153109 polymorphism on IL-27 promoter activity was evaluated using a luciferase reporter assay, and THP-1 cell a

9. elevated IL-27 correlated well with bacterial sepsis among neonatal patients with bloodstream infections

10. Impaired TLR-induced IL-27 secretion and augmented expression of antigen presentation molecules result in chronic T cell activation which may fuel T cell-mediated inflammation in type-2 diabetes.

11. Serum levels of IL-27 were decreased in patients with Parkinson's disease compared to those in healthy subjects.

12. Early-stage non-small cell lung cancer is characterized by high IL-27 expression in the lower airways.

13. IL-27 production was elevated during Clostridium difficile infection in humans and mice. Infected WSX-1-/- mice experienced increased weight loss, enhanced colonic histology damage, less Clostridium difficile clearance, and decreased survival compared to wild-type controls during Clostridium difficile infection.

14. In humans only heterodimeric IL-27 is present.

15. the efficacy of IL-27 in inhibiting endotoxin tolerance in human THP-1 monocytes and PMA-THP-1 macrophages is affected by membrane-bound and soluble CD14 expression.

16. SMM do not induce the production of TNF-alpha and other cytokines while inhibiting LPS-induced IL-27 production by inhibiting the classical NF-kappaB pathway.

17. IL-27 serum levels were significantly differences in early onset and late onset severe preeclampsia than in gestation matched healthy pregnancies (p=0.0376, p=0.0085, respectively). Our results suggest IL-27 might be a useful biomarker for disease severity in preeclampsia.

18. Over-expression of IL-17 and IL-27 are involved in the pathogenesis of liver damage in children with human cytomegalovrius infection.

19. Interleukin-27 differentially regulates the expression of seven novel microRNAs.

20. Patients with tuberculous pleural effusion have an about 26-fold higher chance of being IL-27 test-positive compared to patients with malignant pleural effusion. [meta-analysis]

Mouse (Murine) Interleukin 27 (IL27) interaction partners

1. IL-27 may break immune tolerance.

2. IL30 plays an important role in regulating prostate cancer stem-like cell behavior and metastatic potential, therefore targeting this cytokine could hamper prostate cancer progression or recurrence

3. IL-27Ra-deficient Tregs and STAT1-deficient Tregs were less efficient than WT Tregs in suppressing antitumor immunity in vivo. CD39 inhibition significantly abolished IL-27-induced suppressive activities of Tregs. Thus, IL-27 signaling in Tregs critically contributes to protumorigenic properties of Tregs via up-regulation of CD39.

4. IL-27 is essential for the generation of IL-10-producing effector cells in primary infection by MHV68.

5. IL-27 induces IL-10 production in CD4 T cells during mouse cytomegalovirus infection.

6. data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model

7. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review)

8. Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4-dependent manner, likely via downregulating LXR expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses.

9. IFN-gamma induces IL-30 production which suppresses IFN-gamma mediated liver inflammation.

10. IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system

11. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

12. this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4(+) single positive thymocytes.

13. TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

14. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1-like cells in celiac disease

15. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.

16. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin.

17. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS injection compared with control specimens.

18. these findings highlight critical roles for IFN-gamma and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation

19. IL-27-induced Sca-1(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes and Blimp1.

20. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27

Pig (Porcine) Interleukin 27 (IL27) interaction partners

1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).