anti-Interleukin 27 (IL27) Antibodies

Human Interleukin 27 (IL27) interaction partners

1. This study failed to find an association between common variants in the functional region of IL27 and coronary artery disease in a Chinese Han population

2. Data point out to a broad set of activities shared by IL-27 and IFN-gamma (show IFNG Antibodies), which are dependent on the common activation of the STAT1 (show STAT1 Antibodies) pathway. These data add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation

3. The current meta-analysis suggests that IL-27 -964A/G polymorphism might enhance cancer risk. However, large-scale and well-designed studies are still needed to confirm the result of our meta-analysis

4. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1 (show IL27RA Antibodies)) on fetal membranes in cases of preterm birth

5. results indicate that elevated IL-27 strongly correlates with EOS (show IKZF4 Antibodies) and may provide additional diagnostic value along with PCT (show UROD Antibodies).

6. serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome

7. Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myo (show IRF6 Antibodies)cardial dysfunction compared with that in controls.

8. IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.

9. IL-27 increased NLRP3 (show NLRP3 Antibodies) inflammasome activation in monocytes with enhanced release of IL-1 beta (show IL1B Antibodies).

10. this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease

Mouse (Murine) Interleukin 27 (IL27) interaction partners

1. TTP (show ZFP36 Antibodies), encoded by Zfp36 (show ZFP36 Antibodies), degrades p28 (show GSTO1 Antibodies) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

2. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (show TXNRD1 Antibodies)-like cells in celiac disease

3. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (show TP53 Antibodies) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.

4. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (show LTF Antibodies).

5. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (show TLR4 Antibodies) injection compared with control specimens.

6. these findings highlight critical roles for IFN-gamma (show IFNG Antibodies) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation

7. IL-27-induced Sca-1 (show Ly6a Antibodies)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (show EOMES Antibodies) and Blimp1 (show PRDM1 Antibodies).

8. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (show IL6 Antibodies) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27

9. We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.

10. These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.

Pig (Porcine) Interleukin 27 (IL27) interaction partners

1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).