anti-Interleukin 27 (IL27) Antibodies

The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Proteins (36) and IL27 Kits (27) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IL27 246778 Q8NEV9
IL27 365368  
IL27 246779 Q8K3I6
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Top anti-IL27 Antibodies at

Showing 10 out of 168 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL 2 to 3 Days
Mouse Rabbit Biotin WB Western Blot of Biotin Conjugated Rabbit anti-IL-27/p28 antibody. Lane 1: Mouse IL-27/p28. Lane 2: None. Load: 50 ng per lane. Primary antibody: None. Secondary antibody: Biotin rabbit secondary antibody at 1:1,000 for 60 min at RT. Block: ABIN925618 for 30 min at RT. Predicted/Observed size: 24 kDa, 24 kDa for Mouse IL-27/p28. Other band(s): None. 100 μg 5 to 7 Days
Mouse Rat Un-conjugated WB Mouse peritoneal macrophages were grown in culture for 24 hours, stimulated with 10ng/mL IFN? and 1ug/mL LPS for 14 hours and incubated for 4 hours with Bredfeldin A. Cells were harvested, washed, aliquoted 1x106 cells per sample, and fixed and permeabilized according to a standard protocol. Samples were stained with biotinylated primary anti-mouse p28 antibody at (0.1 - 10ug/mL primary antibody alongside negative controls of unstimulated cells and isotype controls. Cells were stained with 0.25ug/mL rat anti-mouse CD107b conjugated Alexa Fluor 647 and PHYCOERYTHRIN Conjugated secondary at 1:100 and analyzed by flow cytometry. Stimulated cells showed increase PE staining (horizontal axis) when compared with unstimulated cells. 100 μg 5 to 7 Days
Human Rabbit Un-conjugated WB 100 μg 11 to 14 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
Mouse Rabbit Un-conjugated WB Detection of recombinant IL27/p28 protein by  anti-Mouse IL-27/p28 antibody. Recombinant mouse IL27/p28 was loaded on to an SDS-PAGE gel at 0.25 µg and after separation, transferred to nitrocellulose. The membrane was blocked with 1% BSA in TBST for 30 min at RT, followed by incubation with primary antibody diluted 1:1,000 in 1% BSA in TBST overnight at 4°C. After washes, the blot was reacted with secondary antibody HRP Goat anti-Rabbit IgG antibody diluted 1:40,000 in blocking buffer  for 30 min at RT. Data was collected using Bio-Rad 4000 MP imaging system. 100 μg 5 to 7 Days
Mouse Rat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Mouse lung tissue lysate, using IL27 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277619 at 1/100 staining Human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
Mouse Rabbit HRP WB Recombinant mouse IL27/p28 was loaded at 0.25 µg. The blot was blocked with 1% BSA in TBST for 30 min at RT. Blot was incubated with HRP rabbit anti-Mouse IL-27/p28 in 1% BSA/TBST at 1:5,000 for 30 min at RT. Data was collected using Bio-Rad 4000 MP. 100 μg 5 to 7 Days
Human Mouse Un-conjugated ELISA, WB 100 μg 11 to 14 Days

Top referenced anti-IL27 Antibodies

  1. Mouse (Murine) Monoclonal IL27 Primary Antibody for ICS, Neut - ABIN2689756 : Hall, Silver, Hunter: The immunobiology of IL-27. in Advances in immunology 2012 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal IL27 Primary Antibody for ELISA, WB - ABIN1002971 : Pflanz, Hibbert, Mattson, Rosales, Vaisberg, Bazan, Phillips, McClanahan, de Waal Malefyt, Kastelein: WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. in Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal IL27 Primary Antibody for ICC, ELISA - ABIN1003282 : Hunter: New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. in Nature reviews. Immunology 2005 (PubMed)
    Show all 3 Pubmed References

  4. Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831 : Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002 (PubMed)

  5. Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043835 : Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  6. Human Polyclonal IL27 Primary Antibody for WB - ABIN252362 : Lee, Amadi-Obi, Yu, Egwuagu: Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. in Immunology 2011 (PubMed)

  7. Mouse (Murine) Monoclonal IL27 Primary Antibody for FACS - ABIN4896017 : Yoshida, Yoshimi, Yoshii, Kim, Dey, Xiong, Munasinghe, Yazawa, ODonovan, Maximova, Sharma, Zhu, Wang, Morse, Ozato: The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. in Immunity 2014 (PubMed)

  8. Human Monoclonal IL27 Primary Antibody for CyTOF, FACS - ABIN4900122 : Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010 (PubMed)

More Antibodies against IL27 Interaction Partners

Human Interleukin 27 (IL27) interaction partners

  1. A role for IL-27 in modulating innate immune responses to bacterial infection.

  2. The IL-27 promoted the regulatory effects of Human mesenchymal stromal cells (hPMSCs) by enhancing the generation of CD4(+)IL-10(+)IFN-gamma(+) T cells from activated PBMC.

  3. IL-27 appears to have a dual role in GBS, with initial pro-inflammatory effects, followed by anti-inflammatory properties during recovery.

  4. IL-27 is part of the antiviral response by uterine cells against potential pathogens; effect of estradiol on IL-27 production and sensitivity by fibroblasts demonstrates a selective hormone action on individual cell types in the uterus and suggests that IL-27 may have differential effects during the menstrual cycle

  5. This work represents an advance in biomedical science because it excludes the rs153109 A/G (IL-27) SNP, but points to the value of the rs1929992 A/G (IL-33) SNP, in determining susceptibility to breast cancer, so that the latter SNP may be used as a marker to identify individuals at high risk for this disease.

  6. Study found no statistically significant difference between the studied groups regarding the IL-27p28 genotypes and revealed that TNF-alpha rs1800629 polymorphism is a potential genetic-susceptibility factor for hepatitis C virus related cirrhosis and hepatocellular carcinoma progression in Egyptian patients.

  7. In vitro IL-8 production by IL-27 and IL-37 pre-treated neutrophils and monocytes was significantly inhibited.

  8. A total of 885 septic patients and 1101 healthy controls were enrolled and genotyped for IL-27 genetic variants (rs153109/-964A > G and rs17855750/2905 T > G). Quantitative real-time PCR and enzyme-linked immunosorbent assays were performed to detect IL-27 expression and cytokine production. The effect of the rs153109 polymorphism on IL-27 promoter activity was evaluated using a luciferase reporter assay, and THP-1 cell a

  9. elevated IL-27 correlated well with bacterial sepsis among neonatal patients with bloodstream infections

  10. Impaired TLR-induced IL-27 secretion and augmented expression of antigen presentation molecules result in chronic T cell activation which may fuel T cell-mediated inflammation in type-2 diabetes.

  11. Serum levels of IL-27 were decreased in patients with Parkinson's disease compared to those in healthy subjects.

  12. Early-stage non-small cell lung cancer is characterized by high IL-27 expression in the lower airways.

  13. IL-27 production was elevated during Clostridium difficile infection in humans and mice. Infected WSX-1-/- mice experienced increased weight loss, enhanced colonic histology damage, less Clostridium difficile clearance, and decreased survival compared to wild-type controls during Clostridium difficile infection.

  14. In humans only heterodimeric IL-27 is present.

  15. the efficacy of IL-27 in inhibiting endotoxin tolerance in human THP-1 monocytes and PMA-THP-1 macrophages is affected by membrane-bound and soluble CD14 expression.

  16. SMM do not induce the production of TNF-alpha and other cytokines while inhibiting LPS-induced IL-27 production by inhibiting the classical NF-kappaB pathway.

  17. IL-27 serum levels were significantly differences in early onset and late onset severe preeclampsia than in gestation matched healthy pregnancies (p=0.0376, p=0.0085, respectively). Our results suggest IL-27 might be a useful biomarker for disease severity in preeclampsia.

  18. Over-expression of IL-17 and IL-27 are involved in the pathogenesis of liver damage in children with human cytomegalovrius infection.

  19. Interleukin-27 differentially regulates the expression of seven novel microRNAs.

  20. Patients with tuberculous pleural effusion have an about 26-fold higher chance of being IL-27 test-positive compared to patients with malignant pleural effusion. [meta-analysis]

Mouse (Murine) Interleukin 27 (IL27) interaction partners

  1. IL-27 may break immune tolerance.

  2. IL30 plays an important role in regulating prostate cancer stem-like cell behavior and metastatic potential, therefore targeting this cytokine could hamper prostate cancer progression or recurrence

  3. IL-27Ra-deficient Tregs and STAT1-deficient Tregs were less efficient than WT Tregs in suppressing antitumor immunity in vivo. CD39 inhibition significantly abolished IL-27-induced suppressive activities of Tregs. Thus, IL-27 signaling in Tregs critically contributes to protumorigenic properties of Tregs via up-regulation of CD39.

  4. IL-27 is essential for the generation of IL-10-producing effector cells in primary infection by MHV68.

  5. IL-27 induces IL-10 production in CD4 T cells during mouse cytomegalovirus infection.

  6. data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model

  7. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review)

  8. Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4-dependent manner, likely via downregulating LXR expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses.

  9. IFN-gamma induces IL-30 production which suppresses IFN-gamma mediated liver inflammation.

  10. IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system

  11. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

  12. this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4(+) single positive thymocytes.

  13. TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

  14. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1-like cells in celiac disease

  15. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.

  16. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin.

  17. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS injection compared with control specimens.

  18. these findings highlight critical roles for IFN-gamma and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation

  19. IL-27-induced Sca-1(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes and Blimp1.

  20. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27

Pig (Porcine) Interleukin 27 (IL27) interaction partners

  1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).

IL27 Antigen Profile

Protein Summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).

Gene names and symbols associated with anti-Interleukin 27 (IL27) Antibodies

  • interleukin 27 (IL27) antibody
  • interleukin 27 (Il27) antibody
  • IL-27 antibody
  • IL-27A antibody
  • IL-27p28 antibody
  • IL27 antibody
  • IL27A antibody
  • IL27p28 antibody
  • Il30 antibody
  • p28 antibody
  • RGD1561420 antibody

Protein level used designations for anti-Interleukin 27 (IL27) Antibodies

IL-27 p28 subunit , IL-27 subunit alpha , IL-27-A , IL27-A , interleukin 30 , interleukin-27 subunit alpha , interluekin 27 , interleukin 27 , interleukin 27 p28 subunit , p28

246778 Homo sapiens
365368 Rattus norvegicus
607880 Canis lupus familiaris
614927 Bos taurus
737725 Pan troglodytes
246779 Mus musculus
493187 Sus scrofa
100349321 Oryctolagus cuniculus
100724612 Cavia porcellus
101122495 Ovis aries
101093822 Felis catus
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