anti-Interleukin 27 (IL27) Antibodies

The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Kits (53) and IL27 Proteins (22) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IL27 246778 Q8NEV9
IL27 365368  
IL27 246779 Q8K3I6
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Top anti-IL27 Antibodies at antibodies-online.com

Showing 10 out of 166 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Mouse Un-conjugated ICS, Neut   0.5 mg Log in to see 6 to 8 Days
$436.43
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-IL27 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Fetal Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated CyTOF, FACS Detection of IL-27 in PHA + IL-2-treated Human PBMC by Flow Cytometry. Human PBMC, treated with 5 ug/mL PHA and 5 ng/mL rhIL-2 (dark orange filled histogram), or untreated (open histogram, yellow line) were stained with Mouse Anti-Human IL-27 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. 100 μg Log in to see 8 to 9 Days
$293.25
Details
Mouse Rat Un-conjugated WB 25 μL Log in to see 1 to 2 Days
$139.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$507.83
Details
Mouse Rabbit Un-conjugated WB Detection of recombinant IL27/p28 protein by anti-Mouse IL-27/p28 antibody. Recombinant mouse IL27/p28 was loaded on to an SDS-PAGE gel at 0.25 µg and after separation, transferred to nitrocellulose. The membrane was blocked with 1% BSA in TBST for 30 min at RT, followed by incubation with primary antibody diluted 1:1,000 in 1% BSA in TBST overnight at 4°C. After washes, the blot was reacted with secondary antibody HRP Goat anti-Rabbit IgG antibody diluted 1:40,000 in blocking buffer (p/n MB-070) for 30 min at RT. Data was collected using Bio-Rad VersaDoc® 4000 MP imaging system. Detection of recombinant IL27/p28 protein by  anti-Mouse IL-27/p28 antibody. Recombinant mouse IL27/p28 was loaded on to an SDS-PAGE gel at 0.25 µg and after separation, transferred to nitrocellulose. The membrane was blocked with 1% BSA in TBST for 30 min at RT, followed by incubation with primary antibody diluted 1:1,000 in 1% BSA in TBST overnight at 4°C. After washes, the blot was reacted with secondary antibody HRP Goat anti-Rabbit IgG antibody diluted 1:40,000 in blocking buffer  for 30 min at RT. Data was collected using Bio-Rad 4000 MP imaging system. 100 μg Log in to see 1 to 2 Days
$389.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 7 to 9 Days
$727.83
Details
Mouse Rabbit Un-conjugated WB IL27 Antibody (Center) (ABIN658144) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the IL27 antibody detected the IL27 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit HRP WB Recombinant mouse IL27/p28 was loaded at 0.25 µg. The blot was blocked with 1% BSA in TBST for 30 min at RT. Blot was incubated with HRP rabbit anti-Mouse IL-27/p28 in 1% BSA/TBST at 1:5,000 for 30 min at RT. Data was collected using Bio-Rad VersaDoc® 4000 MP. Recombinant mouse IL27/p28 was loaded at 0.25 µg. The blot was blocked with 1% BSA in TBST for 30 min at RT. Blot was incubated with HRP rabbit anti-Mouse IL-27/p28 in 1% BSA/TBST at 1:5,000 for 30 min at RT. Data was collected using Bio-Rad 4000 MP. 100 μg Log in to see 1 to 2 Days
$389.00
Details
Mouse Rat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$639.83
Details

IL27 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-IL27 Antibodies

  1. Mouse (Murine) Monoclonal IL27 Primary Antibody for ICS, Neut - ABIN2689756 : Hall, Silver, Hunter: The immunobiology of IL-27. in Advances in immunology 2012 (PubMed)
    Show all 7 Pubmed References

  2. Mouse (Murine) Monoclonal IL27 Primary Antibody for FACS - ABIN4896017 : Yoshida, Yoshimi, Yoshii, Kim, Dey, Xiong, Munasinghe, Yazawa, ODonovan, Maximova, Sharma, Zhu, Wang, Morse, Ozato: The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. in Immunity 2014 (PubMed)

  3. Human Monoclonal IL27 Primary Antibody for CyTOF, FACS - ABIN4900122 : Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010 (PubMed)

  4. Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831 : Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002 (PubMed)

  5. Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043835 : Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

More Antibodies against IL27 Interaction Partners

Human Interleukin 27 (IL27) interaction partners

  1. This study failed to find an association between common variants in the functional region of IL27 and coronary artery disease in a Chinese Han population

  2. Data point out to a broad set of activities shared by IL-27 and IFN-gamma (show IFNG Antibodies), which are dependent on the common activation of the STAT1 (show STAT1 Antibodies) pathway. These data add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation

  3. The current meta-analysis suggests that IL-27 -964A/G polymorphism might enhance cancer risk. However, large-scale and well-designed studies are still needed to confirm the result of our meta-analysis

  4. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1 (show IL27RA Antibodies)) on fetal membranes in cases of preterm birth

  5. results indicate that elevated IL-27 strongly correlates with EOS (show IKZF4 Antibodies) and may provide additional diagnostic value along with PCT (show UROD Antibodies).

  6. serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome

  7. Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myo (show IRF6 Antibodies)cardial dysfunction compared with that in controls.

  8. IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.

  9. IL-27 increased NLRP3 (show NLRP3 Antibodies) inflammasome activation in monocytes with enhanced release of IL-1 beta (show IL1B Antibodies).

  10. this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease

Mouse (Murine) Interleukin 27 (IL27) interaction partners

  1. TTP (show ZFP36 Antibodies), encoded by Zfp36 (show ZFP36 Antibodies), degrades p28 (show GSTO1 Antibodies) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

  2. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (show TXNRD1 Antibodies)-like cells in celiac disease

  3. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (show TP53 Antibodies) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.

  4. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (show LTF Antibodies).

  5. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (show TLR4 Antibodies) injection compared with control specimens.

  6. these findings highlight critical roles for IFN-gamma (show IFNG Antibodies) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation

  7. IL-27-induced Sca-1 (show Ly6a Antibodies)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (show EOMES Antibodies) and Blimp1 (show PRDM1 Antibodies).

  8. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (show IL6 Antibodies) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27

  9. We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.

  10. These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.

Pig (Porcine) Interleukin 27 (IL27) interaction partners

  1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).

IL27 Antigen Profile

Protein Summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).

Gene names and symbols associated with anti-Interleukin 27 (IL27) Antibodies

  • interleukin 27 (IL27) antibody
  • interleukin 27 (Il27) antibody
  • IL-27 antibody
  • IL-27A antibody
  • IL-27p28 antibody
  • IL27 antibody
  • IL27A antibody
  • IL27p28 antibody
  • Il30 antibody
  • p28 antibody
  • RGD1561420 antibody

Protein level used designations for anti-Interleukin 27 (IL27) Antibodies

IL-27 p28 subunit , IL-27 subunit alpha , IL-27-A , IL27-A , interleukin 30 , interleukin-27 subunit alpha , interluekin 27 , interleukin 27 , interleukin 27 p28 subunit , p28

GENE ID SPECIES
246778 Homo sapiens
365368 Rattus norvegicus
607880 Canis lupus familiaris
614927 Bos taurus
737725 Pan troglodytes
246779 Mus musculus
493187 Sus scrofa
100349321 Oryctolagus cuniculus
100724612 Cavia porcellus
101122495 Ovis aries
101093822 Felis catus
Selected quality suppliers for anti-IL27 (IL27) Antibodies
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