Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) Proteins (IL28RA)

The protein encoded by IL28RA belongs to the class II cytokine receptor family. Additionally we are shipping Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) Antibodies (62) and Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IL28RA 242700 Q8CGK5
IL28RA 163702 Q8IU57
Rat IL28RA IL28RA 362628  
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Top Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) Proteins at

Showing 3 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

IL28RA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
Human ,
, ,

More Proteins for Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA) Interaction Partners

Mouse (Murine) Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA) interaction partners

  1. Ifnlr1 is expressed in the epithelial fraction along the length of the gastrointestinal tract and is essential for induction of IFN-lambda-mediated sterilizing innate immunity to norovirus.

  2. interferon-lambda has a role in noncanonical signaling through IFNLR1, which tightens the blood-brain barrier and restricts viral neuroinvasion and pathogenesis

  3. Rotavirus infection induces production of IFN-lambda by IECs and of IL-22 by ILC3 cells.

  4. IL-28R is essential for optimal in vivo activity of natural killer cells

Human Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA) interaction partners

  1. Interferon lambda receptor 1 (IFNLR1) mRNA is increased in human rhinovirus (HRV) bronchiolitis infants. Increased IFNLR1 transcript levels characterized HRV-infected infants with more severe bronchiolitis and blood eosinophilia. IFNLR1 transcript is increased in infants infected with HRVC species.

  2. IFN-lambda4 suppressed HIV infection of macrophages. This IFN-lambda4-mediated HIV inhibition was compromised by the antibodies against IFN-lambda receptor complex, IFN-lambdaR1/IL-10R2.

  3. Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with hepatitis B virus infection, and IFNLR1-rs4649203 was associated with hepatitis B recovery. Moreover, the authors demonstrated the clear relevance of 5 polymorphisms in IFNA1, IFNA2, IFNL4 with hepatocellular carcinoma.

  4. In this structure, the receptor peptide forms an 85-A-long extended chain, in which both the previously identified box1 and box2 regions bind simultaneously to the FERM and SH2-like domains of JAK1.

  5. Results show that IFNLR1 box1 and box2 motifs are required for stable complex formation with JAK1 and the crystal structure of JAK1 reveals IFNLR1 box1 binding site in the FERM domain. Also, structure-based mutagenesis reveals IFNLR1 PxxLxF motif that is essential for binding. Structure of JAK1 with IL10RA box1 indicates conservation among class II receptors.

  6. Selective expression of IFNlambdaR1 was considered to be a plus point towards the targeted anti-viral activity of IFNlambdas but artificial control on its expression will surely make IFNlambdas a better drug with enhanced activity.

  7. expression of IL-28RA mRNA may be correlated with the pathogenesis of systemic lupus erythematosus

  8. Polymorphism within the IL-28R1, but not in IL-28B, is associated with benign prostatic hyperplasia and lower urinary tract symptoms in Chinese.

  9. Results show that the distribution of IL10RB and IL28RA genotypes among the Hepatitis C virus-infected and control groups did not differ significantly.

  10. This study is the first to show the activation of a type III interferon response in low-risk human papillomavirus positive cervical cells and suggests that the lack of this response may be related to lesion progression.

  11. IL28RA polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of IR, but this association was different depending on hepatic fibrosis and HCV genotype.

  12. Epigenetic reprogramming of IFNLR1-mediated response potentiates antiviral activity and suppresses tumor growth.

  13. IFN-lambda receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-lambda3 genotype and with nonresponsiveness to IFN-alpha therapies.

  14. The rs12980275 AG/GG genotype and rs10903035 G allele remained independently associated with early pegylated interferon and ribavirin failure of hepatitis C in hepatitis C/HIV coinfected patients.

  15. Plasmacytoid dendritic cells are major producers of IFN-lambda2 (a type III interferon) in response to viral stimulation and also express functional receptors for this cytokine.

  16. No consistent association is found between IL28RA and multiple sclerosis in a Basque-Spanish population.

  17. two SNPs in IL28RA are correlated with susceptibility to HCV infection and spontaneous viral clearance, which implicates a primary role of IL28RA in the outcomes of HCV infection

  18. IFN-lambdaR1 consists of two distinct domains having fibronectin type III topology.

  19. Although the IFN-lambda1(Bac)-IFN-lambda1R1 and IFN-lambda1(Ins)-IFN-lambda1R1 complexes differed only in the nature of the expression system used for the ligand, their crystallization conditions and crystal forms were quite different

  20. study supports that IFN-lambdas do not influence every type of cell and that membrane-associated variant IFN-lambda R1 expression is not sufficient to ensure cellular sensitivity toward these cytokines.

Interleukin 28 Receptor, alpha (Interferon, lambda Receptor) (IL28RA) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene names and symbols associated with IL28RA

  • interferon lambda receptor 1 (IFNLR1)
  • interferon, lambda receptor 1 (ifnlr1)
  • interferon, lambda receptor 1 L homeolog (ifnlr1.L)
  • interferon lambda receptor 1 (Ifnlr1)
  • interferon, lambda receptor 1 (Ifnlr1)
  • CRF2-12 protein
  • CRF2/12 protein
  • IFNLR protein
  • ifnlr1 protein
  • IL-28R1 protein
  • Il28ra protein
  • LICR2 protein
  • RGD1562689 protein

Protein level used designations for IL28RA

interferon lambda receptor isotype 1 , interferon lambda receptor soluble 1 , interleukin 28 receptor, alpha (interferon, lambda receptor) , interferon lambda receptor , interleukin-28 receptor subunit alpha-like , IFN-lambda R1 , IL-28 receptor subunit alpha , IL-28R-alpha , IL-28RA , class II cytokine receptor 12 , cytokine receptor class-II member 12 , cytokine receptor family 2 member 12 , interferon-lambda receptor 1 , interleukin 28 receptor alpha , interleukin-28 receptor subunit alpha , CRF2-12 , IFN-lambda receptor 1 , IFN-lambda-R1 , class II cytokine receptor CRF2/12 , interferon lambda receptor 1 , interferon lambda, receptor 1 , interleukin 28 alpha receptor , interleukin 28 receptor A , interleukin or cytokine receptor 2 , likely interleukin or cytokine receptor 2

419694 Gallus gallus
456628 Pan troglodytes
612276 Canis lupus familiaris
100329166 Xenopus (Silurana) tropicalis
100381152 Xenopus laevis
100450173 Pongo abelii
100588530 Nomascus leucogenys
242700 Mus musculus
163702 Homo sapiens
362628 Rattus norvegicus
616826 Bos taurus
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