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IL28B encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping Interleukin 28B (Interferon, lambda 3) Antibodies (111) and Interleukin 28B (Interferon, lambda 3) Proteins (18) and many more products for this protein.
Showing 6 out of 31 products:
Human IL28B ELISA Kit for Sandwich ELISA - ABIN414558
Rallón, Soriano, Naggie, Restrepo, McHutchison, Vispo, Benito: Impact of IL28B gene polymorphisms on interferon-?3 plasma levels during pegylated interferon-?/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV. in The Journal of antimicrobial chemotherapy 2012
Show all 4 Pubmed References
Human IL28B ELISA Kit for Sandwich ELISA - ABIN457021
Khairy, Fouad, Mabrouk, El-Akel, Awad, Salama, Elnegouly, Shaker: The impact of interleukin 28b gene polymorphism on the virological response to combined pegylated interferon and ribavirin therapy in chronic HCV genotype 4 infected egyptian patients using data mining analysis. in Hepatitis monthly 2013
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results suggest that IL-28B induces more mature NK cells to defend against viruses, in addition to its direct antiviral activity
IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX (show HSP ELISA Kits) vaccination but does not improve the protective immune responses.
the role of IFN-lambda in IDO (show IDO1 ELISA Kits) regulation was investigated after influenza infection of respiratory epithelial cells.
Data indicate that rotavirus infection induces production of interferon (show IFNA ELISA Kits)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 ELISA Kits)) by intestinal epithelial cells.
Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c (show ITGAX ELISA Kits)(+) DC function in experimental allergic asthma.
IFN-alpha (show IFNA ELISA Kits), IFN-beta (show IFNB1 ELISA Kits), and IFN-gamma (show IFNG ELISA Kits) were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta (show IFNB1 ELISA Kits) and IFN-gamma (show IFNG ELISA Kits) were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection
the duration of IFNlambda signaling to JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) is different from that of IFNalpha
intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR (show IFNAR1 ELISA Kits)-/- mice
IL-28A (show IL28A ELISA Kits) emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury
Type III interferon (show IFNA ELISA Kits)/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll (show TLR4 ELISA Kits)-like receptors, largely mediated by inducing an antiviral state in epithelial cells.
only IL28B rs12979860-CT and TT genotypes seem to contribute to the occurrence of chronic HCV infection in the cohort of Uruguayan population studied. Considering that a trend towards a higher frequency of "good" response genotypes was observed in responder patients, we believe that IL28B rs12979860 genotyping could be a useful tool for predicting different therapies outcome, including in the DAA era.
our data show a significant association between rs12979860 polymorphism and hematologic response to IFN-alpha (show IFNA ELISA Kits) in PV and in the combined cohort of PV and ET. These findings imply that inborn variations in the genes involved in inflammation are related to the outcome of IFN-alpha (show IFNA ELISA Kits) treatment in MPNs.
The selected donor with a predictable and favourable IL-28B genotype will not confer a benefit on the recipient in the living donor liver transplantation setting.
IL-28B polymorphisms may be useful predictive factors for chronic periodontitis (CP) and correlated to the susceptibility to CP infection.
IL28B rs12979860 polymorphism does not influence the susceptibility to HIV-1 and the AIDS development in Moroccan patients, however, this polymorphism may affect the response to HAART treatment as measured by CD4 (show CD4 ELISA Kits)+ T cell counts
This is the first report on a diagnostic test for simultaneous genotyping of IFNL3, ABCB11, and RNF7 in Chronic hepatitis C (CHC) patients. Reliable and inexpensive, the assay should provide useful information for the clinical management of CHC, like identification of patients at risk of rapid disease progression or with high chances of response to classic therapy.
Results showed that INF-lambda serum concentration was increased in Alzheimer's disease (AD) and mild cognitive impairment (MCI) carrying the IFNL3 T allele compared to healthy controls (HC). Anti-HSV-1 Ab titers were higher in AD and MCI individuals carrying the IRF7 (show IRF7 ELISA Kits) AA genotype compared to HC. IFNL3 rs12979860 and IRF7 (show IRF7 ELISA Kits) rs6598008 polymorphisms may modulate immune responses against HSV-1 via their effect on the IFN-lam (show TSC1 ELISA Kits)...
Regardless of viral genotype we found no association between IL28B genotype and the risk of vertical transmission of HCV. The IL28B genotype CC, which has been shown to be favourable in other settings, was not protective of vertical transmission of HCV.
The authors concluded that in the Chinese population, HLA-A*02:01 and DRB1 (show RBM45 ELISA Kits)*11:01 might be associated with the host capacity to clear hepatitis C virus independent of IL28B, which suggests that the innate and adaptive immune responses both play an important role in the control of hepatitis C virus.
In a cohort of patients affected by HCV chronic hepatitis with genotypes 1 and 4, the prevalence of interleukin 28B (IL28B) genotypes, the possible association between IL28B polymorphism and severity of liver damage, the role of IL28B CC as a predictor of outcome were investigated
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, interferon alpha
, interferon lambda-3
, interleukin 28
, cytokine Zcyto22
, interferon lambda-4
, interferon, lambda 4
, interleukin 28B (interferon, lambda 3)
, interleukin 28C