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IL29 encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping IL29 Kits (37) and IL29 Proteins (29) and many more products for this protein.
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The review focuses on the value of the type I and III interferon (show IFNA Antibodies) subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).
Interferon (show IFNA Antibodies) lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation.
STAT2 (show STAT2 Antibodies) recruits USP18 (show USP18 Antibodies) to the type I IFN receptor subunit IFNAR2 (show IFNAR2 Antibodies) via its constitutive membrane-distal STAT2 (show STAT2 Antibodies)-binding site.
IL-29 stimulates inflammation and cartilage degradation by OA FLS, indicating that this cytokine is likely involved in the pathogenesis of OA.
IL-29 is a potential biomarker for disease activity in anti-cyclic citrullinated peptide-antibodies positive rheumatoid arthritis patients.
this study shows that serum levels of IL-29 play a role in the pathogenesis of Hashimoto's thyroiditis in Turkey
serum levels of IL-32 (show IL32 Antibodies) and TNF-alpha (show TNF Antibodies) may be diagnostic markers, and serum IL-29 levels may be associated with good prognosis in patients with gastric cancer
Serum levels of IL-29 and IFN-gamma (show IFNG Antibodies) are predictive of relapse outcomes after hepatitis C treatment.
IL-29 selectively induces CXCR3A-binding chemokines (CXCL9 (show CXCL9 Antibodies), CXCL10 (show CXCL10 Antibodies), CXCL11 (show CXCL11 Antibodies)) in skin cells. Murine IL-29 counterpart induces skin T-cell infiltration and inflammation in mice.
activation of TLR7 upregulated the expression levels of IFN-lambda1 and MMP-9 were increased by ~3 fold, whereas other genes (p53, PTEN, TIMP-1) were upregulated by ~2 fold, and VEGF was marginally upregulated after 10 min.
We here report the molecular cloning, expression and antiviral activity of porcine IL-29
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, cytokine Zcyto21
, interferon lambda-1
, interleukin 29 (interferon, lambda 1)
, interleukin 28B
, interferon lamda 1