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IL29 encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping IL29 Antibodies (83) and IL29 Kits (37) and many more products for this protein.
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In conclusion, IL-29 enhanced CXCL10 (show CXCL10 Proteins) production in human oral epithelial cells via the p38 MAPK (show MAPK14 Proteins), STAT3 (show STAT3 Proteins), and NF-kappaB (show NFKB1 Proteins) pathways, which might control Th1 (show TH1L Proteins)-cell accumulation in periodontal lesions and be involved in pathological processes in periodontal disease.
The DNA binding domain of Ku70 was essential for formation of the Ku70-STING complex. Knocking down STING in primary human macrophages inhibited their ability to produce IFN-lambda1 in response to transfection with DNA or infection with the DNA virus HSV-2 (herpes simplex virus-2). Together, these data suggest that STING mediates the Ku70-mediated IFN-lambda1 innate immune response to exogenous DNA or DNA virus infection.
The review focuses on the value of the type I and III interferon (show IFNA Proteins) subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).
Interferon (show IFNA Proteins) lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation.
STAT2 (show STAT2 Proteins) recruits USP18 (show USP18 Proteins) to the type I IFN receptor subunit IFNAR2 (show IFNAR2 Proteins) via its constitutive membrane-distal STAT2 (show STAT2 Proteins)-binding site.
IL-29 stimulates inflammation and cartilage degradation by OA FLS, indicating that this cytokine is likely involved in the pathogenesis of OA.
IL-29 is a potential biomarker for disease activity in anti-cyclic citrullinated peptide-antibodies positive rheumatoid arthritis patients.
this study shows that serum levels of IL-29 play a role in the pathogenesis of Hashimoto's thyroiditis in Turkey
serum levels of IL-32 (show IL32 Proteins) and TNF-alpha (show TNF Proteins) may be diagnostic markers, and serum IL-29 levels may be associated with good prognosis in patients with gastric cancer
Serum levels of IL-29 and IFN-gamma (show IFNG Proteins) are predictive of relapse outcomes after hepatitis C treatment.
We here report the molecular cloning, expression and antiviral activity of porcine IL-29
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, cytokine Zcyto21
, interferon lambda-1
, interleukin 29 (interferon, lambda 1)
, interferon lamda 1