Inversin Proteins (INVS)

INVS encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. Additionally we are shipping Inversin Antibodies (17) and Inversin Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
INVS 27130 Q9Y283
INVS 16348 O89019
Rat INVS INVS 313228  
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Top Inversin Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

INVS Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Inversin (INVS) Interaction Partners

Xenopus laevis Inversin (INVS) interaction partners

  1. Inversin relays Frizzled-8 (show FZD8 Proteins) signals to promote proximal pronephros development.

  2. The present study indicates that calmodulin binding sites (IQ motifs) are crucial in controlling the biological activity of both mouse and Xenopus inv proteins

Human Inversin (INVS) interaction partners

  1. Collectively, these results indicated that inversin might promote the tumorigenicity of lung cancer cells and serve as a novel therapeutic target of non-small cell lung cancer.

  2. Akt (show AKT1 Proteins) phosphorylates inversin at amino acids 864-866 that are required not only for Akt (show AKT1 Proteins) interaction, but also for inversin dimerization.

  3. Truncating mutations in NPHP2 gene is associated with nephronophthisis-related ciliopathy.

  4. ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8 (show NEK9 Proteins), INVS and NPHP3 (show NPHP3 Proteins).

  5. INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  6. has conserved ankyrin repeat and IQ domains and interacts with calmodulin

  7. analysis of a homozygous mutation in exon 13 of inversin (INVS) (C2719T, R907X) in a patient with retinitis pigmentosa and renal failure [case report]

  8. Thus, although considered a common variant, inv(10)(p11.2q21.2) has a single ancestral founder among northern Europeans.

  9. Cystic kidney disease has been linked to mutations in the Invs gene in mice with an inversion of embryonic turning (inv/inv) and the INVS (NPHP2) gene in human infantile nephronophthisis (NPH).

  10. screened 43 families with infantile nephronophthisis (ESRD less than 5 years of age) for NPHP2 and NPHP3 (show NPHP3 Proteins) mutations and determined genotype-phenotype correlations

Mouse (Murine) Inversin (INVS) interaction partners

  1. We constructed sub-congenic lines to more specifically localize the modifier and have determined it resides in a 3.2 Mb interval containing 28 genes. These include Invs and Anks6, which are both excellent candidates for the modifier as mutations in these genes result in PKD (show PRKD1 Proteins) and both genes are known to genetically and physically interact with Nek8 (show NEK8 Proteins).

  2. Ciliary abnormalities are associated with nphp2 mutant mice.

  3. Loss of NPHP2 causes ciliogenesis defects.

  4. the significance of Inversin in controlling cell migration processes

  5. Nek8 (show NEK8 Proteins) acts downstream of Inv function

  6. Inv acts as a molecular anchor for Nphp3 (show NPHP3 Proteins) and Nek8 (show NEK8 Proteins) in the proximal segment of primary cilia.

  7. the inv gene product functions in several cellular compartments, including the nucleus and cell-cell adhesion sites

  8. Molecular cloning of a gene for inversion of embryo turning (inv) with cystic kidney. Deduced amino acid sequence shows 15 successive repeats of Ank (show ANKH Proteins)/Swi6 motif in its N-terminal domain. Mutation causes situs inversus and cysts in kidney in inv mutant.

  9. inv has a role in kidney disease: inv mutant mouse has renal cysts resembling infantile NPHP2

  10. The localization of inversin in distal tubules in the kidney and in extrarenal tissues suggests that the expression of this protein has an important function in a variety of organs.

Zebrafish Inversin (INVS) interaction partners

  1. Nek8 (show NEK8 Proteins) acts downstream of Inv function

Inversin (INVS) Protein Profile

Protein Summary

This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with Inversin Proteins (INVS)

  • inversin S homeolog (invs.S)
  • inversin (INVS)
  • inversin (Bm1_38710)
  • inversin (PTRG_09181)
  • Inversin (EAMY_RS33690)
  • inversin (LOAG_11716)
  • inversin (invs)
  • inversin (Invs)
  • INV protein
  • INVS protein
  • invs-a protein
  • MGC140477 protein
  • NPH2 protein
  • Nphp2 protein
  • RGD1563359 protein
  • wu:fe47e11 protein

Protein level used designations for Inversin Proteins (INVS)

inversin , inversion of embryo turning homolog , inversion of embryonic turning , nephrocystin-2 , inversion of embryo turning protein , nephrocystin 2

378491 Xenopus laevis
473146 Pan troglodytes
529698 Bos taurus
6102626 Brugia malayi
6347469 Pyrenophora tritici-repentis Pt-1C-BFP
8912192 Erwinia amylovora CFBP1430
9949175 Loa loa
100010929 Monodelphis domestica
100075447 Ornithorhynchus anatinus
100144697 Xenopus (Silurana) tropicalis
100344027 Oryctolagus cuniculus
100453593 Pongo abelii
100594079 Nomascus leucogenys
27130 Homo sapiens
16348 Mus musculus
313228 Rattus norvegicus
395234 Gallus gallus
442950 Canis lupus familiaris
245946 Danio rerio
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