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INF2 represents a member of the formin family of proteins. Additionally we are shipping INF2 Proteins (6) and INF2 Kits (4) and many more products for this protein.
Showing 10 out of 48 products:
Human Polyclonal INF2 Primary Antibody for IHC, IHC (p) - ABIN4325815
Sun, Al-Romaih, MacRae, Pollak: Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus. in EBioMedicine 2015
INF2-mediated actin polymerization on the endoplasmic reticulum stimulates mitochondrial division by two independent mechanisms: (1) mitochondrial calcium uptake, leading to inner mitochondrial membrane constriction; and (2) Drp1 (show CRMP1 Antibodies) oligomerization, leading to outer mitochondrial membrane constriction.
Studies indicate that INF2, a formin (show FMN1 Antibodies), that is mutated in hereditary renal and neurodegenerative disorders.
Disease causing mutations in inverted formin 2 regulate its binding to G-actin (show ACTB Antibodies), F-actin capping protein (CapZ (show CAPZB Antibodies) alpha-1 (show CAPZA1 Antibodies)) and profilin 2 (show PFN2 Antibodies).
hese findings reveal novel molecular events underlying the regulation of INF2 function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer.
All individuals with INF2 mutations presenting with a thrombotic microangiopathy also had atypical hemolytic uremic syndrome risk haplotypes, potentially accounting for the genetic pleiotropy
Propose that examination of INF2 expression may help to differentiate minimal change disease from focal segmental glomerulosclerosis and evaluate the clinical severity of steroid resistance nephrotic syndrome in children.
FHOD1 (show FHOD1 Antibodies) and INF2 are novel regulators of inter- and intra-structural contractility of podosomes.
The authors propose Spire1C isoform cooperates with INF2 to regulate actin assembly at endoplasmic reticulum-mitochondrial contacts.
Report novel mutations in the inverted formin 2 gene of Chinese families contributing to focal segmental glomerulosclerosis.
Assembly and turnover of short actin filaments by the formin (show FMN1 Antibodies) INF2 and profilin (show PFN1 Antibodies).
These data support a critical regulatory role for INF2 in trophoblast invasion-a necessary process for placentation.
In mice, normal INF2 function is not required for glomerular development but normal INF2 is required for regulation of the actin-based behaviors necessary for response to and/or recovery from injury.
Data highlight a unique mechanism of formin (show FMN1 Antibodies) action in which mDia1 and INF2 function in series to stabilize MTs (show NEU2 Antibodies) and point to IQGAP1 (show IQGAP1 Antibodies) as a scaffold that facilitates the activation of one formin (show FMN1 Antibodies) by another.
The perinuclear actin rim (show RIMS1 Antibodies) structure colocalized with INF2 on stimulation, and INF2 depletion resulted in attenuation of the rim (show RIMS1 Antibodies) formation.
Splice variant-specific cellular function of the formin (show FMN1 Antibodies) INF2 in maintenance of Golgi architecture.
Data suggest a role for INF1 in microtubule modification and potentially in coordinating microtubule and F-actin structure.
This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.
HBEAG-binding protein 2 binding protein C
, HBEBP2-binding protein C
, inverted formin-2
, formin, inverted