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Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Additionally we are shipping Junctophilin 1 Proteins (6) and many more products for this protein.
Showing 10 out of 25 products:
Human Polyclonal JPH1 Primary Antibody for ELISA, WB - ABIN527954
Vihola, Sirito, Bachinski, Raheem, Screen, Suominen, Krahe, Udd: Altered expression and splicing of Ca(2+) metabolism genes in myotonic dystrophies DM1 and DM2. in Neuropathology and applied neurobiology 2013
Human Polyclonal JPH1 Primary Antibody for ICC, IF - ABIN4327979
Boncompagni, Thomas, Lopez, Allen, Yuan, Kranias, Franzini-Armstrong, Perez: Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. in PLoS ONE 2012
Results show that JPH1 and GDAP1 (show GDAP1 Antibodies) share a common pathway and depend on each other; therefore, JPH1 can contribute to the phenotypical consequences of GDAP1 (show GDAP1 Antibodies) mutations.
This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden.
This study demonstrates that both JP1 and JP2 (show JPH2 Antibodies) in skeletal muscle undergo Ca2 (show CA2 Antibodies)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (show CA2 Antibodies)+ is raised within the physiological range for a sustained period
JP1 and JP2 (show JPH2 Antibodies) can facilitate the assembly of DHPR (show QDPR Antibodies) with other proteins of the excitation-contraction coupling machinery
JP1 gene is expressed during the whole process of cardiogenesis, while JP1 protein only appears during the early stage.
an important fraction of resting plasmalemmal Ca(2 (show CA2 Antibodies)+) permeability is mediated by the Orai1 (show TMEM132A Antibodies) pathway, which contributes to the control of [Ca(2 (show CA2 Antibodies)+)](rest) and resting Ca(2 (show CA2 Antibodies)+) stores and that this pathway is defective in JP1 KO myotubes
Skeletal muscle JP1/2 damage is significantly associated with early (0-3 days) strength deficits after performance of eccentric contractions.
Abnormal junctional membrane structures in cardiac myocytes in transgenic mice expressing junctophilin type 1.
We report a novel Junctophilin subtype, JP-4 (show JPH4 Antibodies), encoded in the human (chromosome 14q11.1) and mouse (chromosome 14C1-2) genomes. JP-4 (show JPH4 Antibodies) shares characteristic structural features with other JP subtypes, and is found in the brain.
Junctophilins support the Ca(2 (show CA2 Antibodies)+)-mediated communication between voltage-gated Ca(2 (show CA2 Antibodies)+) channels, which modulates the excitability of Purkinje cells and is fundamental to cerebellar long-term depression and motor functions.
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
junctophilin type 1
, junctophilin type1
, junctophilin 1