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The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]\; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]..
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The authors find that KHSRP associates with the regulatory domain of RIG-I (show DDX58 Proteins) to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA).
we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs.
KSRP decreased EGR3 (show EGR3 Proteins) mRNA stability in an ARE-independent manner.
TGF-beta (show TGFB1 Proteins)-induced KHSRP silencing is central in a pathway leading to gene-expression.
mechanistic evidence that KSRP promotes the down-regulation of Spry4 (show SPRY4 Proteins) by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.
The interaction between the KLHL12 (show KLHL12 Proteins) and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells.
The miRNA biogenesis factors, DDX17 (show DDX17 Proteins) and KHSRP, regulate the protein level of Ago2 (show EIF2C2 Proteins) in human cells.
Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis.
High FBP2 expression is associated with doxorubicin resistance in breast cancer .
Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells
Report KSRP/mRNA/microRNA interactions in chromatoid body of spermatids regulating spermatogenesis.
CXCL-2 (show CXCL2 Proteins) and HMOX-1 (show HMOX1 Proteins) were upregulated in H. pylori infection after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori.
IFN-gamma (show IFNG Proteins) production was increased in spleen cells of KSRP(-/-) mice.
Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1 (show HNRNPA1 Proteins).
KSRP is critical in governing hepatic lipid metabolism through controlling Per2 (show PER2 Proteins) expression
KSRP modulation of GAP-43 (show GAP43 Proteins) mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR (show MLXIP Proteins)-150 expression.
This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR (show MLXIP Proteins)-145 expression.
KSRP is required to maintain P19 cells in undifferentiated state and that its inactivation can orient cells towards neural differentiation.
Our results outline a critical role for KSRP in regulating pro-inflammatory mediators and have implications for a wide range of CNS inflammatory and autoimmune diseases.
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997
KH-type splicing regulatory protein
, KH-type splicing regulatory protein (FUSE binding protein 2)
, FUSE binding protein 2
, far upstream element-binding protein 2
, FUSE-binding protein 2
, KH type-splicing regulatory protein
, MAP2 RNA trans-acting protein 1
, MAP2 RNA trans-acting protein MARTA1
, zipcode-binding protein 2