KIAA0226 Proteins (KIAA0226)

Negatively regulates endocytic trafficking. Additionally we are shipping KIAA0226 Antibodies (60) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KIAA0226 9711 Q92622
Mouse KIAA0226 KIAA0226 100502698 Q80U62
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

KIAA0226 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for KIAA0226 Interaction Partners

Human KIAA0226 interaction partners

  1. Rubicon thus functions as an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion.

  2. HCV, by differentially inducing the expression of Rubicon and UVRAG (show UVRAG Proteins), temporally regulated the autophagic flux to enhance its replication.

  3. This study demonistrated that KIAA0226 mutation impairs Rubicon endosomal localization

  4. New DNA sequencing technologies are enabling us to investigate the whole or large targeted proportions of the genome in a rapid, affordable, and comprehensive way. Exome and targeted sequencing rundataxin genes causing ataxia.

  5. Rubicon may thus be pivotal to generating an optimal intracellular immune response against microbial infection.

  6. Rubicon differentially targets signaling complexes, depending on environmental stimuli, and may function to coordinate various immune responses against microbial infection.

  7. Rubicon and PLEKHM1 (show PLEKHM1 Proteins) specifically and directly interact with Rab7 (show RAB7B Proteins) via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 (show PLEKHM1 Proteins) uniquely regulates membrane trafficking via simultaneously binding both Rab7 (show RAB7B Proteins) and PI3-kinase (show PIK3CA Proteins)

  8. a critical role of the Rubicon RUN domain in PI3KC3 and autophagy regulation

  9. Rubicon serves as a previously unknown Rab7 (show RAB7B Proteins) effector to ensure the proper progression of the endocytic pathway.

  10. we report the identification of a family with three children affected with a new form of recessive ataxia, which we suggest naming 'Salih ataxia', and of a frameshift mutation of KIAA0226 (rundataxin) that segregates with the disease

Mouse (Murine) KIAA0226 interaction partners

  1. Rubicon specifically interacts with the interferon (show IFNA Proteins) regulatory factor (IRF (show TRIM63 Proteins)) association domain (IAD) of IRF3 (show IRF3 Proteins), and this interaction leads to inhibition of the dimerization of IRF3 (show IRF3 Proteins), which negatively regulates interferon (show IFNA Proteins)-mediated antiviral response.

  2. Rubicon deficiency enhances autophagic flux in the heart and protects mice from lethality and reduction in stroke volume induced by LPS (show TLR4 Proteins).

  3. Data indicate that Rubicon (Kiaa0226) and NOX2 (gp91phox (show CYBB Proteins)) are involved in microtubule-associated protein (show SPAG5 Proteins) LC3 (show MAP1LC3A Proteins)-associated phagocytosis.

  4. Beclin 1 (show BECN1 Proteins) and its binding proteins orchestrate the precise function of the class III PI(3 (show PI3 Proteins))K in regulating autophagy at multiple steps.

  5. Two Beclin 1 (show BECN1 Proteins) associated proteins, Atg14L and Rubicon, were identified.

KIAA0226 Protein Profile

Protein Summary

Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity.

Gene names and symbols associated with KIAA0226 Proteins (KIAA0226)

  • RUN and cysteine rich domain containing beclin 1 interacting protein (RUBCN)
  • KIAA0226 (KIAA0226)
  • RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein (Rubcn)
  • 5330403K09 protein
  • Kiaa0226 protein
  • mKIAA0226 protein
  • Rubicon protein

Protein level used designations for KIAA0226 Proteins (KIAA0226)

KIAA0226 , RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein , RUN domain protein as Beclin 1-interacting and cysteine-rich containing , baron , beclin-1 associated RUN domain containing protein , run domain Beclin-1 interacting and cystein-rich containing protein , run domain Beclin-1 interacting and cysteine-rich containing protein , rundataxin

424920 Gallus gallus
460971 Pan troglodytes
9711 Homo sapiens
100502698 Mus musculus
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