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KIAA0319L is a candidate gene for dyslexia susceptibility.[provided by RefSeq, Apr 2009]..
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Analyses of Kiaa0319L (AU040320) and double Kiaa0319 (show KIAA0319 Antibodies);AU040320 knockouts (dKO) revealed no evidence for impaired cortical lamination, neuronal migration, neurogenesis or other anatomical abnormalities. However, dKO mice displayed an auditory deficit in a behavioral gap-in-noise detection task. Recordings of click-evoked auditory brainstem responses revealed suprathreshold deficits in wave III amplitude in AU040320-KO mice.
genetic association study in Han population in China: Data suggest an SNP in PXK (show PXK Antibodies) [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L [rs2275247(A/G)] or JAZF1 (show JAZF1 Antibodies) [rs1635852(C/T)] are not associated.
Results identify KIAA0319L as novel susceptibility loci for Systemic sclerosis (SSc (show CYP11A1 Antibodies)) and systemic lupus erythematosus (SLE). KIAA0319L was overexpressed in peripheral blood cells of SSc (show CYP11A1 Antibodies) and SLE patients compared with healthy controls.
Kiaa0319-like protein interacts with Nogo Receptor 1, supporting the idea that Kiaa0319-like protein participates in axon guidance.
KIAA0319L remains an intriguing positional and functional candidate for RD, especially when considered alongside the supporting evidence for its homolog KIAA0319 (show KIAA0319 Antibodies) on chromosome 6p.
This gene is a candidate gene for dyslexia susceptibility.
, dyslexia-associated protein KIAA0319-like protein
, likely ortholog of H. sapiens polycystic kidney disease 1-like (PKD1-like)
, polycystic kidney disease 1-like
, polycystic kidney disease 1-related