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a dynamic TIP150-cortactin (show CTTN Proteins) interaction orchestrates directional cell migration via coupling dynamic microtubule plus ends to the cortical cytoskeleton.
A dynamic interaction of MCAK (show KIF2C Proteins)-TIP150 orchestrated by Aurora A (show AURKA Proteins)-mediated phosphorylation governs entosis via regulating microtubule plus-end dynamics and cell rigidity.
TIP150-EB1 (show MAPRE2 Proteins) interaction governs kinetochore microtubule plus-end plasticity and establish that the temporal control of the TIP150-EB1 (show MAPRE2 Proteins) interaction by PCAF (show KAT2B Proteins) acetylation ensures chromosome stability in mitosis.
These results suggest a role for CAZIP in development and function of the heart and nervous system in vertebrates.
TIP150 facilitates the EB1 (show MAPRE2 Proteins)-dependent loading of MCAK (show KIF2C Proteins) onto MT plus ends and orchestrates the dynamics at the plus end of MTs (show TIMM8A Proteins).
Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity).
, microtubule-associated tumor suppressor candidate 2
, +TIP of 150 kDa
, cardiac zipper protein
, microtubule plus-end tracking protein TIP150
, tracking protein of 150 kDa
, microtubule-associated tumor suppressor candidate 2 homolog