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KEL encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. Additionally we are shipping KEL Proteins (7) and many more products for this protein.
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B cells require signaling from IFN-alpha (show IFNA Antibodies)/beta to produce alloantibodies to the human KEL glycoprotein in mice
Absence of Kell was accompanied by changes in erythrocyte K(+), Mg(2 (show MCOLN1 Antibodies)+), Na(+) & Ca(2 (show CA2 Antibodies)+) transport associated with changes in mean cellular volume & corpuscular hemoglobin (show HBB Antibodies) concentration mean. Kel loss increased Mg(2 (show MCOLN1 Antibodies)+) permeability.
The expression of Kell glycoprotein on RBCs is not critical to the erythrocyte function
Through molecular genotyping we also identified polymorphisms in RhCE (show RHCE Antibodies), Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.
High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group (show DARC Antibodies) genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles.
x-ray analysis of Kell blood group (show XK Antibodies) protein
Kell K2 antigen is a catalytically active metalloprotease, but the rare Kell K1 antigen is inactive
KEL6 red blood cells have endothelin-3 (show EDN3 Antibodies)-converting enzyme activity
Results demonstrate the lack of Kell expression in rodent neuronal cells and strongly suggest the same for human cerebral tissue, in which the Kellprotein was exclusively observed on RBCs in cerebral blood vessels.
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.
Kel blood group protein
, Kell blood group, metallo-endopeptidase
, Kell protein
, kell blood group glycoprotein homolog
, kell blood group antigen
, kell blood group glycoprotein