KEL antibody (Kell Blood Group, Metallo-Endopeptidase) (AA 213-243)

Details for Product anti-KEL Antibody No. ABIN951237, Supplier: Log in to see
Antigen
  • CD238
  • Ece3
  • ECE3
  • Kell blood group
  • Kell blood group, metallo-endopeptidase
  • Kel
  • KEL
Epitope
AA 213-243, Middle Region
12
8
7
5
4
4
3
2
1
1
1
1
1
1
1
1
Reactivity
Human
48
5
2
Host
Rabbit
38
9
2
1
Clonality
Polyclonal
Conjugate
This KEL antibody is un-conjugated
3
3
3
2
2
2
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
36
26
19
5
4
3
3
2
1
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide between 213-243 amino acids from the Central region of Human CD238 / KEL
Isotype Ig Fraction
Specificity This antibody recognizes Human CD238 / KEL (Center).
Purification Protein A column, followed by peptide affinity purification
Plasmids, Primers & others Plasmids, Primers & others KEL products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD238 / KEL (KEL Antibody Abstract)
Background This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases.Synonyms: Kell blood group glycoprotein
Molecular Weight 82824 Da
Gene ID 3792
NCBI Accession NP_000411
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Kell Blood Group, Metallo-Endopeptidase (KEL) (AA 213-243), (Middle Region) antibody (ABIN951237) Flow cytometric analysis of K562 cells using CD238 / KEL Antibody (Center) Cat.-No AP...
Western Blotting (WB) image for anti-Kell Blood Group, Metallo-Endopeptidase (KEL) (AA 213-243), (Middle Region) antibody (ABIN951237) Western blot analysis of CD238 / KEL Antibody (Center) in K562 cell line lysates (35u...
Background publications Di Cristofaro, Silvy, Chiaroni, Bailly: "Single PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and one year of routine clinical use." in: The Journal of molecular diagnostics : JMD, Vol. 12, Issue 4, pp. 453-60, 2010 (PubMed).

Boturão-Neto, Chiba, Bordin: "Novel IVS6-13C>T mutation recognized as a cause of discrepancy between phenotyping and genotyping in KEL*3,4 polymorphism identification." in: Transfusion, Vol. 50, Issue 3, pp. 735-7, 2010 (PubMed).

Yang, Wang, Wang, Chen, Guo, Zhang, Zhu: "Two novel null alleles of the KEL gene detected in two Chinese women with the K(null) phenotype." in: Transfusion medicine (Oxford, England), Vol. 19, Issue 5, pp. 235-44, 2009 (PubMed).

Körmöczi, Scharberg, Gassner: "A novel KEL*1,3 allele with weak Kell antigen expression confirming the cis-modifier effect of KEL3." in: Transfusion, Vol. 49, Issue 4, pp. 733-9, 2009 (PubMed).

Lee, Debnath, Redman: "Active amino acids of the Kell blood group protein and model of the ectodomain based on the structure of neutral endopeptidase 24.11." in: Blood, Vol. 102, Issue 8, pp. 3028-34, 2003 (PubMed).