Keratin 12 Proteins (KRT12)

KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Additionally we are shipping Keratin 12 Antibodies (70) and Keratin 12 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KRT12 3859 Q99456
KRT12 268482  
KRT12 360625 Q6IFW5
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Top Keratin 12 Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Escherichia coli (E. coli) Rat His tag,S tag 100 μg 15 to 18 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 25 μg 11 to 12 Days
Yeast Rabbit His tag   1 mg 60 to 71 Days
Yeast Xenopus laevis His tag   1 mg 60 to 71 Days

KRT12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Keratin 12 (KRT12) Interaction Partners

Human Keratin 12 (KRT12) interaction partners

  1. We identified a heterozygous genetic mutation (c.394 C>G, p.L132V) in the KRT12 gene in six Japanese patients with inherited Meesmann corneal dystrophy. This is the first study to confirm this genetic mutation in Japanese Meesmann corneal dystrophy patients. This mutation has been independently reported in an American Meesmann corneal dystrophy patient, confirming its pathogenicity.

  2. RT-PCR showed that K3 and K12 transcripts were absent from patient cells, but present in healthy control preparations.

  3. KC can co-exist with GCD. The missense mutation (c.370G > A) in the TGFBI gene and insert mutation (c.1456-1457ins GAT) in the KRT12 gene were identified in a 23-year-old male patient with concurrent KC and GCD.

  4. we show that the two PAX6 isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12). PAX6 isoform-a induced KRT3 expression by targeting its upstream region. KLF4 enhanced this induction. A combination of PAX6 isoform-b, KLF4, and OCT4 induced KRT12 expression

  5. Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals.

  6. We identified a novel missense mutation of the KRT12 gene in Meesmann corneal dystrophy. The in vivo confocal microscopy examinations revealed previously unreported depth-dependent ultrastructural changes in the living cornea.

  7. Exon sequencing of KRT3 and KRT12 in six affected and eight unaffected individuals did not detect any mutations or nucleotide sequence variants in Meesmann epithelial corneal dystrophy.

  8. The Leu132Pro missense mutation is within the helix-initiation motif of the keratin and is predicted to result in a significant structural change of the K12 protein.

  9. The lead siRNA, with an IC(50) of thirty picomolar, showed no keratin off-target effects or activation of TLR3 in the concentration ranges tested.

  10. Novel missense mutation within the highly conserved helix-initiation motif of KRT12 causing Meesmann's corneal dystrophy in a German family.

  11. Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy.

  12. A novel missense mutation (Y429C) in KRT12 lead to MCD in 2 unrelated Taiwanese families.

  13. Mutation in the KRT12 gene is associated with Meesmann corneal dystrophy

  14. Mutation associated with symptomatic phenotype of Meesmann's corneal dystrophy. Results in substitution of proline for arginine in helix termination motif that may disrupt normal helix, leading to dramatic structural change of keratin 12 protein.

  15. This is the second family recently diagnosed with Meesmann dystrophy in Denmark. The family represents its own distinct genotype, independent of previously reported ones. All patients with microcysts were asymptomatic.

  16. The novel L433R mutation of the KRT12 gene found in two members of this Japanese family caused Meesmann corneal dystrophy (MECD).

Mouse (Murine) Keratin 12 (KRT12) interaction partners

  1. data revealed that the early corneal epithelial progenitor cells expressing keratin-12 originated from limbus, and gave rise to the transit amplifying cells that migrated centripetally to differentiate into corneal epithelial cells

  2. clonal limbal stem cells randomly activate Krt12 alleles in the process of terminal differentiation in cornea

Keratin 12 (KRT12) Protein Profile

Protein Summary

KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy.

Gene names and symbols associated with Keratin 12 Proteins (KRT12)

  • keratin 91 (krt91)
  • keratin 12 (KRT12)
  • keratin 12 (krt12)
  • keratin 12 (Krt12)
  • keratin 12 S homeolog (krt12.S)
  • AI835216 protein
  • fb05e09 protein
  • K12 protein
  • Ka12 protein
  • Krt-12 protein
  • Krt1-12 protein
  • wu:fa91b04 protein
  • wu:fa97a07 protein
  • wu:fb05e09 protein
  • xk81b2 protein

Protein level used designations for Keratin 12 Proteins (KRT12)

keratin 12 , fa97a07 , krtt1c19a , cytokeratin , type I keratin , keratin 12 (Meesmann corneal dystrophy) , CK-12 , cytokeratin-12 , keratin, type I cytoskeletal 12 , keratin-12 , Keratin, type I cytoskeletal 12 (Cytokeratin 12) , keratin complex 1, acidic, gene 12 , K12 , keratin K12 , type I keratin KA12 , keratin, type I cytoskeletal 47 kDa , B2 keratin

445051 Danio rerio
100034663 Canis lupus familiaris
100144436 Xenopus (Silurana) tropicalis
468241 Pan troglodytes
3859 Homo sapiens
268482 Mus musculus
360625 Rattus norvegicus
398464 Xenopus laevis
100009289 Oryctolagus cuniculus
Selected quality suppliers for Keratin 12 Proteins (KRT12)
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