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KRT17 encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Additionally we are shipping Keratin 17 Antibodies (336) and Keratin 17 Kits (36) and many more products for this protein.
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Krt17 was demonstrated to contribute to areca nut-induced oral malignancy
TGFbeta (show TGFB1 Proteins)/SMAD (show SMAD1 Proteins)/miR (show MLXIP Proteins)-486-3p signaling axis in keratinocytes regulated K17 expression and cell proliferation. We conclude that the loss of miR (show MLXIP Proteins)-486-3p in psoriatic epidermis leads to K17 protein overexpression and contributes to the pathogenesis of psoriasis.
inflammatory cytokines promoted Nrf2 (show GABPA Proteins) nuclear translocation in psoriatic epidermis, which led to elevated expression of K6, K16 (show KRT16 Proteins), and K17, thus promoting keratinocyte proliferation and contributing to the pathogenesis of psoriasis.
KRT17 promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 overexpression by GLIs in oral squamous cell carcinoma (OSCC)..
TGF-beta1 (show TGFB1 Proteins)-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 (show ZFP42 Proteins) signaling pathway.
K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS (show AR Proteins) and is a powerful, negative prognostic marker for patient survival.
the data suggest that the loss of Krt17 may foster an overall protective environment for lesion-prone cervical tissue.
K17 is expressed in a subset of triple-negative breast cancers, and is a marker of poor prognosis in patients with advanced stage and ER(-)/HER2 (show ERBB2 Proteins)(-) breast cancer.
MiR (show MLXIP Proteins)-138 may regulate K17 protein expression to affect cell proliferation and apoptosis by targeting hTERT gene in keratinocytes from psoriatic vulgaris patients.
The pattern of CK17 expression is a highly sensitive marker for distinguishing cutaneous lymphadenoma from basal cell carcinoma in small samples.
TGF-beta1 (show TGFB1 Proteins)-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 (show ZSCAN1 Proteins) signaling pathway.
p53 (show TP53 Proteins) operates as a direct Krt17 repressor that invites therapeutic targeting in radiodermatitis .
genetic loss of caspase-7 (show CASP7 Proteins) promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7 (show CASP7 Proteins)-mediated cleavage of keratin-17.
Data indicate that keratin 17 (k17) regulates autoimmune regulator Aire (show AIRE Proteins) to promote skin tumorigenesis.
These findings functionally integrate K17, hnRNP K (show HNRNPK Proteins), and gene expression along with RSK (show RPS6KA1 Proteins) and CXCR3 (show CXCR3 Proteins) signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis
KRT17 is necessary for oncogenic transformation in Ewing sarcoma and accounts for much of the GLI1 (show GLI1 Proteins)-mediated transformation function but via a mechanism independent of AKT (show AKT1 Proteins) signaling.
Cytochrome b5 (show CYB5A Proteins) and cytokeratin 17 are biomarkers in bronchoalveolar fluid signifying onset of acute lung injury.
IL-22 up-regulates K17 expression in keratinocytes in a dose-dependent manner through STAT3- and ERK1/2-dependent mechanisms.
Type I keratin (show KRT12 Proteins) 17 protein is phosphorylated on serine 44 by p90 (show GPAM Proteins) ribosomal protein S6 kinase 1 (RSK1 (show RPS6KA1 Proteins)) in a growth- and stress-dependent fashion
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.
, keratin 17 epitope S1
, keratin 17 epitope S2
, keratin 17 epitope S4
, keratin, type I cytoskeletal 17
, type I keratin KA17
, keratin complex 1, acidic, gene 17
, keratin 17
, keratin 16
, Keratin, type I cytoskeletal 17