KRT17 Protein (AA 1-441, full length) (His-SUMO Tag)

Catalog No. ABIN5709827

Product Details

Target: KRT17 (Keratin 17 (KRT17))

Protein Type: Recombinant

Protein Characteristics: full length, AA 1-441

Origin: Cow

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This KRT17 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MTTTIRHFSS GSIKGSSGLA GGSSRSCRVS GSLGGGSCRL GSAGGLGSGL GGSSYSSCYS FGSGGGYGSG GYVSGGYGGG FGGVDGLLVG GEKATMQNLN DRLASYLDKV RALEEANTEL ELKIRDWYQK QAPGPAPDYS SYFKTIEDLR NKIHTATVDN ANLLLQIDNA RLAADDFRTK FETEQALRVS VEADINGLRR VLDELTLARA DLEMQIENLK EELAYLRKNH EEEMKALRGQ VGGEINVEMD AAPGVDLSRI LNEMRDQYEK MAEKNRKDAE DWFFSKTEEL NREVATNSEL VQSGKSEISE LRRTLQALEI ELQSQLSMKA SLEGSLAETE NRYCMQLSQI QGLIGSVEEQ LAQLRCEMEQ QNQEYKILLD VKTRLEQEIA TYRRLLEGED AHLTQYKTKE PVTTRQVRTI VEEVQDGRVI SSREQVHQTS H

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: KRT17 (Keratin 17 (KRT17))

Alternative Name: K1C17 (KRT17 Products)

Synonyms: K17 Protein, Krt1-17 Protein, PC Protein, PC2 Protein, PCHC1 Protein, Ka17 Protein, KRT17 Protein, krt16 Protein, si:dkeyp-113d7.7 Protein, KRT14 Protein, keratin 17 Protein, keratin 17 L homeolog Protein, keratin 17, type I Protein, keratin, type I cytoskeletal 17 Protein, Krt17 Protein, KRT17 Protein, krt17 Protein, krt17.L Protein, LOC100737113 Protein, LOC102177275 Protein

Background: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "st cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Molecular Weight: 64.71 kDa

UniProt: A1L595