Keratin 5 Proteins (KRT5)

The protein encoded by KRT5 is a member of the keratin gene family. Additionally we are shipping Keratin 5 Antibodies (286) and Keratin 5 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KRT5 110308 Q922U2
KRT5 3852 P13647
KRT5 369017 Q6P6Q2
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Top Keratin 5 Proteins at antibodies-online.com

Showing 9 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human GST tag 100 μg Log in to see 11 Days
$411.40
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse Keratin 5 Protein. 100 μg Log in to see 11 to 18 Days
$596.97
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human Keratin 5 Protein. 100 μg Log in to see 11 to 18 Days
$639.61
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,429.17
Details
Escherichia coli (E. coli) Rat His tag,S tag   100 μg Log in to see 15 to 18 Days
$752.00
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$625.39
Details

KRT5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
, ,
Rat (Rattus)

More Proteins for Keratin 5 (KRT5) Interaction Partners

Mouse (Murine) Keratin 5 (KRT5) interaction partners

  1. We demonstrate using lineage-tracing systems that urothelial regeneration following augmentation cystoplasty with acellular grafts exclusively depends on host keratin 5-expressing basal cells to repopulate all lineages of the de novo urothelium at implant sites

  2. CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14.

  3. Taken together, our data demonstrated that Krt5-expressing cells could be involved in the natural pancreas self-healing process and the renewal of beta cells after AP in adult mice. It is promising that promoting conversion of Krt5-expressing cells into functional beta cells may be a novel method to mitigate the development of diabetes mellitus after AP in vivo.

  4. RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling.

  5. widespread destruction of airway and alveolar epithelial cells following severe influenza infection triggers a wound-healing response that initiates in the airways with the proliferation of rare airway-resident SOX2+ Lin- progenitor cells. These cells then give rise to nascent KRT5+ cells in remodeled airways and populate the damaged alveolar parenchyma.

  6. Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells.

  7. B-1 B cells transiently and partially express K5 in bone marrow and are potent for both natural antibody production and antigen presentation.

  8. Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.

  9. NMHC IIA may play critical roles in the early trophoblast-derived ectoplacental cone and extraembryonic ectoderm in Keratin 5-Cre transgenic mice.

  10. Mice lacking the prostate epithelial AR have increased apoptosis in epithelial CK8-positive luminal cells and increased proliferation in epithelial CK5-positive basal cells.

  11. The involvement of Hsc70 and Hsp70 in mutant keratin degradation was demonstrated using CHIP-p.Met1_Ala142del (DeltaTPR-CHIP).

  12. p63 protein is essential for the embryonic development of vibrissae and teeth; while it localizes with K5 in vibrissae, it is not fully colocalized with nuclear Ki67 expression

  13. keratin 5 mutations contribute to epidermolysis bullosa simplex in a mouse model by inducing local inflammation that mediates a stress response

  14. Cytokines involved in the recruitment, maturation, and migration of Langerhans cells in the epidermis, are upregulated in the skin of K5(-/-) and epidermolysis bullosa simplex patients.

  15. DeltaNp63 alone can restore the expression of the basal keratins and reinitiate the failed epidermal differentiation program in the skin of p63 null animals.

Human Keratin 5 (KRT5) interaction partners

  1. combination of KRT5 and KRT20 allowed identification of patients with a very poor prognosis (KRT20/KRT5(-), 5-year DSS 0%, p < 0.0001). In silico analysis of the independent MDACC cohorts revealed congruent results (5-year DSS for KRT20 low vs. high: 84% vs. 40%, p = 0.042).

  2. Cytokeratin 5/6 and CK8/18 immunohistochemistry on 150 cases of triple negative breast cancers was performed and association with various clinicopathological features was evaluated.

  3. Data indicate that cytokeratin 5/6 (CK5/6) is an independent prognostic biomarker in urothelial carcinoma and therefore can be used in the prognostic stratification of the patients with bladder cancer.

  4. CK5/6 expression changed according to the morphological components in adenoid cystic carcinoma of the breast.

  5. EGFR and CK5/6 expression could serve as biomarkers for identifying triple-negative breast cancer patients with poor survival

  6. Basal cell carcinoma (BCC) typically shows patchy CD56 expression and diffuse CK5/6 positivity. These 2 markers can be used to distinguish between BCC and Merkel cell carcinoma in challenging cases.

  7. Negative staining for CK5/6 and p63 can be helpful to distinguish Well-differentiated neuroendocrine tumors (WDNETs) from cutaneous adnexal neoplasms. It is important to consider WDNETs in the differential diagnosis of cutaneous adnexal neoplasms as low-grade tumors may be the first sign of aggressive metastatic disease

  8. this study adds a further 10 novel mutations to the catalogued genotype-phenotype correlations in epidermolysis bullosa simplex and demonstrates a potential modifying effect of SNPs on the phenotype. We therefore support the notion of full DNA sequencing of both KRT5 and KRT14 genes so as to not miss any variants in the genes contributing to the phenotype.

  9. Flat Intraurothelial Neoplasia Exhibiting Diffuse Immunoreactivity for CD44 and Cytokeratin 5 (Urothelial Stem Cell/Basal Cell Markers): A Variant of Intraurothelial Neoplasia Commonly Associated With Muscle-invasive Urothelial Carcinoma

  10. Dual small interfering RNA (siRNA) silencing of RARalpha and RARgamma reversed RA blockade of P4-induced CK5. Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE

  11. Cytokeratin 5/6 protein expression as a frequent feature of high-grade serous ovarian carcinoma with various staining patterns. Cytokeratin 5/6 in combination with ER-alpha proved to be a negative prognostic marker.

  12. The proportion of serous ovarian carcinomas with high K5/6 or high K5 immunostaining was significantly increased following neoadjuvant chemotherapy. K5 can be used to predict serous ovarian cancer prognosis and identify cancer cells that are resistant to chemotherapy.

  13. CK5 and p40 are good diagnostic markers for squamous cell carcinoma and superior to p63

  14. The expression of CK5/6 and of P63 suggests a squamous differentiation including in the basaloid thyroid lymphoepithelial complexes

  15. Immunocytochemistry using this antibody cocktail comprises five antibodies recognising p63, and cytokeratins ( 7, 18, 5 and 14) showed good sensitivity and specificity for diagnosing breast cancers. Thus, this method is useful for mammary cytology using FNA

  16. the consistency test results indicated the inter-observer agreement was more robust in MS images for HER2 , CK5/6 and ER than that in RGB images for HER2 , CK5/6 and ER .

  17. the luminal cells of adenoid cystic carcinoma show a unique aberrant staining pattern for cytokeratin 5/6 that may aid in the differential diagnosis

  18. Results provide further accumulation of case series of EBS-MP and DPR may provide more accurate diagnostic criteria for genetic disorders of the K5/K14 pair, previously believed to be independent disorders.

  19. The results introduce a case of special generalized DDD with a family history that clinically resembles dyschromatosis universalis hereditaria (DUH), and suggest that KRT5 may be the candidate gene.

  20. Authors herein defined two distinct HNSCCs groups (EGFR(+) and K5(+)) with several sub-classes, identifiable by the additional assessment of p53, Bcl2 and CD117.

Cow (Bovine) Keratin 5 (KRT5) interaction partners

  1. NMHC IIA may play critical roles in the early trophoblast-derived ectoplacental cone and extraembryonic ectoderm in Keratin 5-Cre transgenic mice.

  2. G to A substitution in all affected animals. This mutation leads to an amino acid change of glutamic acid to lysine in the final E (478) of the KLLEGE motif of the protein.

Zebrafish Keratin 5 (KRT5) interaction partners

  1. data show that a cis-element of the DNA segment in the CKII gene is required for epidermal cell-specific expression of CKII and that a minimal region upstream of the transcription start site is required for this expression restricted to epidermal cells

Keratin 5 (KRT5) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene names and symbols associated with Keratin 5 Proteins (KRT5)

  • keratin 5 (Krt5)
  • keratin 5 (KRT5)
  • keratin 5 (krt5)
  • 3300001P10Rik protein
  • AW146334 protein
  • CK-5 protein
  • CK5 protein
  • ckii protein
  • DDD protein
  • DDD1 protein
  • EBS2 protein
  • K5 protein
  • Keratin-5 protein
  • Krt2-5 protein
  • KRT5A protein
  • KRT75 protein
  • Sak57 protein
  • Tfip8 protein
  • wu:fb02h09 protein
  • wu:fj02d02 protein
  • wu:fk78b12 protein
  • zfCKII protein

Protein level used designations for Keratin 5 Proteins (KRT5)

58 kDa cytokeratin , CK-5 , cytokeratin 5 , cytokeratin-5 , keratin complex 2, basic, gene 5 , keratin, type II cytoskeletal 5 , keratin-5 , tuftelin interacting protein 8 , type-II keratin Kb5 , 58 kda cytokeratin , epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types , keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) , K5 , keratin, type II cytoskeletal 60 kDa, component III , keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types) , type II cytokeratin , keratin 75 , type II alpha keratin IIA , Cytokeratin-5 , Type-II keratin Kb5

GENE ID SPECIES
110308 Mus musculus
3852 Homo sapiens
281268 Bos taurus
369017 Rattus norvegicus
797351 Danio rerio
407779 Gallus gallus
100615215 Pan troglodytes
100687760 Canis lupus familiaris
100511564 Sus scrofa
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